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| 1 | Progress in the development of vaccines for hepatitis C virus infection显示文摘The hepatitis C virus(HCV), first described in 1989, is now a leading cause of liver cirrhosis and hepatocellular carcinoma. With more than 170 million people infected globally, this virus is a major public health issue. The current standard therapy is based on interferon in combination with ribavirin. This costly therapy often fails to completely clear the infection and is associated with adverse side effects. Recent anti-HCV therapies are interferon-free direct-acting antiviral(DAA) regimens for HCV, including simeprevir, sofosbuvir, and ledipasvir, which have effects on non-structural proteins. DAA regimens have several advantages, such as specifically targeting HCV viral replication, accompanied by very high sustained virological response rates and lower side effects like flu-like syndrome. These facts plus the fact that most HCV cases progress to chronic infection suggest the potential need for an efficient HCV vaccine. Different innovative methods, including methods based on peptide, recombinant protein, DNA, vector-based, and virus-like particles, have been introduced for the development of HCV vaccines. An extensive number of studies have been published on these vaccines, and some vaccines were even tested in clinical trials. In the current review, progress in the development of preventive and therapeutic vaccines against the HCV is reviewed in the context of peptide vaccines, recombinant protein vaccines, HCV-like particle, DNA vaccines and viral vectors expressing HCV genes. | Faezeh Ghasemi Sina Rostami Zahra Meshkat | 2015 | World Journal of Gastroenterology2015，21，42： | 6 |
| 2 | Investigation of the effects of alumina nanoparticles on spur gear surface roughness and hob tool wear in hobbing process显示文摘 | Khalilpourazary S Meshkat S S | 2014 | International Journal of Advanced Manufacturing Technology2014，71，912： | 1 |
| 3 | Evaporation reduction po- tential in an undisturbed soil irrigated with surface drip and sand tube irrigation显示文摘 | Meshkat M Wamer R C Workman S R | 2000 | Trans of the ASAE2000，，： | 1 |
| 4 | Evaporation reduction potential in an undisturbed soil irrigated with surface drip and sand tube irrigation显示文摘 | Meshkat M Warner R C Workman S R | 2000 | Transactions of the ASAE2000，43，1： | 1 |
| 5 | Evaporation reduction potential in an undisturbed soil irrigated with surface drip and sand tube irrigation显示文摘 | Meshkat M Warner R C Workman S R | 2000 | Trans of the ASAE2000，43，1： | 1 |
| 6 | Prevalence of Acinetobacter baumannii harboring ISAbal/blaOXA-23-1ike family in a burn center 显示文摘 | Salimizand H Noori N Meshkat Z | 2015 | Burns2015，41，5： | 1 |
| 7 | Reverse genetic analysis of a putative,influenza virus M2 HXXXW-like motif in the p7 protein of hepatitis C virus显示文摘 | Meshkat Z Audsley M Beyer C | 2009 | J Viral Hepat2009，16，3： | 1 |
| 8 | Evaporation re- duction potential in an undisturbed soil irrigated with surface drip and sand tube irrigation 显示文摘 | Meshkat M Warner R C Workman S R | 2000 | Trans of the ASAE2000，43，1： | 1 |
| 9 | Reverse genetic analysis of a putative, influenza virus M2 HXXXW-like motif in the p7 protein of hepatitis C virus显示文摘 | Meshkat Z Audsley M Beyer C | 2009 | Viral Hepat2009，16，3： | 1 |
| 10 | Evaporation reduction potential in an undisturbed soil irrigated with surface drip and sand tube irrigation显示文摘 | Meshkat M Warner R C Workman S R | 2000 | Transactions of the ASAE2000，43，1： | 1 |
| 11 | Evaporation reduction potential in an undisturbed soil irrigated with surface drip and sand tube irrigation显示文摘 | Meshkat M Warner R C Workman S R | 2000 | Trans of Thasae2000，43，1： | 1 |
| 12 | Reverse genetic anaIysis of a putative, influenza virus M2 HXXXW- like motif in the p7 protein of hepatitis C virus显示文摘 | Meshkat Z Audsley M Beyer C | 2009 | J Viral Hepat2009，16，3： | 1 |
| 13 | Evaporation reduction potential in an undisturbed soil irrigated with surface drip and sand tube irrigation显示文摘 | Meshkat M R C Warner S R Workman | 2000 | Trans of the ASAE2000，43，1： | 1 |
| 14 | Dependability Analysis of Systems with on-demand and Active Failure Modes,Using Dynamic Fault Trees显示文摘 | Meshkat L Dugan J B Andrews J D | 2002 | IEEE Transactions on Reliability2002，51，2： | 1 |
| 15 | Evaporation reduction potential in an undisturbed soil irrigated with surface drip and sand tube irrigation显示文摘 | Meshkat M Warner R C Workman S R | 2000 | Taransactions of the ASAE2000，43，1： | 1 |
| 16 | Evaporation reduction potential in an undisturbed soil irrigated with surface drip and sand tube irrigation显示文摘 | Meshkat M R C Warner R C Workman S R | 2000 | Tarans ASAE2000，43，1： | 1 |
| 17 | Dependability Analysis of Systems with On-demand and Active Failure Modes, Using Dynamic Fault Trees显示文摘 | Meshkat L Dugan J B Andrews J D | 2002 | IEEE Transactions on Reliability2002，51，2： | 1 |
| 18 | Comparison ofCulture and PCR Methods for Diagnosis of Mycobacterium tuber-culosis in Different Clinical Specimens显示文摘 | Gholoobi A Masoudi -Kazemabad A Meshkat M | 2014 | Jundishapur J Microbiol2014，7，2： | 1 |
| 19 | Comparison of water and temperature distribution profiles under sand tube irrigation显示文摘 | Meshkat M R C Warner S R W | 1998 | Transactions of the ASAE1998，41，6： | 1 |
| 20 | Demotivating Factors In Learning English: The Case Of Iran显示文摘 | Maryam Meshkat Masoumeh Hassani | 2012 | Procedia - Social and Behavioral Sciences2012，，： | 1 |
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