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| 1 | In vivo anti-salmonella activity of aqueous extract of Euphorbia prostrata Aiton(Euphorbiaceae) and its toxicological evaluation显示文摘Objective: To investigate the in vivo anti-salmonella activity and the safety of aqueous extract of Euphorbia prostratra(E. prostratra), a plant commonly used in Cameroon by traditional healers.Methods: A Salmonella typhimurium-infected rat model was used for the study. The physiological, biochemical and histopathological markers of possible side effects of this extract were studied using standard methods.Results: The extract had a significant effect on the number of viable Salmonella typhimurium recovered from faeces, and could stop salmonellosis after 8 and 10 days of treatment for male and female rats, respectively, with non-toxic doses. However, the biochemical and histopathological analyses revealed that at relatively high doses(≥ 73.48 mg/kg for female and ≥ 122.71 mg/kg for male) the extract could induce liver damage, as illustrated by a rise of serum transaminases' levels and significant inflammation of the parenchyma and portal vein.Side effects were also observed on the kidneys, as shown by both serum and urinary creatinine,and urinary proteins.Conclusions: The overall results indicate that the aqueous extract of E. prostrata has the potential to provide an effective treatment for salmonellosis, including typhoid fever. However,it is necessary to extrapolate these results in large animals, in further studies. | Donald Sédric Tala Donatien Gatsing Siméon Pierre Chegaing Fodouop Charles Fokunang Fabrice Kengni Merline Namekong Djimeli | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，4： | 3 |
| 2 | Phosphorus fractions in Brazilian Cerrado soils as affected by tillage显示文摘 | Pavinato P S Merlin A Rosolem C A | 2009 | Soil and Tillage Research2009，105，1： | 1 |
| 3 | The influence ofsalinity on oil-mineral aggregate formation显示文摘 | Le Floch S Guyomarch J Merlin F X | 2002 | Spill Science & Technology Bulletin2002，8，1： | 1 |
| 4 | Importance of specific IgM antibodies in 116 patients with various stages of syphilis显示文摘 | Merlin S Andre J Alacoque B | 1985 | Genitourin Med1985，6，2： | 1 |
| 5 | 显示文摘 | Marcais C Bernard S Merlin M | 2000 | Diabetologia2000，43，11： | 1 |
| 6 | Severe hypertriglyceridaemia in type II diabetes : involvment of apoC Ⅲ , Sst- I polymorphism, LPL mutation and apo E3 deficiency 显示文摘 | Marcaise C Bernard S Merlin M | 2000 | Diabetologia2000，43，11： | 1 |
| 7 | Study of staphylococcal toxic shock syndrome toxin in human epithelial cell culture 显示文摘 | VLADIMIR M K MERLIN S B HECTOR S | 1984 | The Journal of Infectious Diseases1984，150，4： | 1 |
| 8 | Precipitation evolution during the annealing of an interstitial-free steel 显示文摘 | Carabajar S Merlin J Massardier V | 2000 | Mater Sci Eng A2000，281，12： | 1 |
| 9 | Abnormal findings in relatives of patients with juvenile hereditary macular degeneration (Stargardt's disease)显示文摘 | Merlin S Landau J | 1970 | Ophthalmologica1970，161，： | 1 |
| 10 | The biphenyl- and 4- chlorobiphenylcatabolic transposon Tn4371, a member of a new family of genomic islands related to IncP and Ti plasmids显示文摘 | Toussaint A Merlin C Monchy S | 2003 | Appl Environ Microbiol2003，69，： | 1 |
| 11 | Precipitation evolution during the annealing of an interstitial - free steel 显示文摘 | Carabajar S Merlin J Massardier V | 2000 | Materials Science and Engineering A2000，281，： | 1 |
| 12 | Genetic heterogeneity of Russian,Estonian and Finnish field rabies viruses显示文摘 | Merlin AE Rybakov S Gruzdev K | 2007 | Arch Virol2007，152，9： | 1 |
| 13 | Software volumetric evaluationof doubling times for differentiating benign versus malignant pul-monary nodules显示文摘 | Revel MP Merlin A Peyrard S | 2006 | AJR2006，187，： | 1 |
| 14 | Prehospital rapid sequence intubation in an emergency medical services system with two advanced life support providers 显示文摘 | Merlin MA Safdar H Calabrese S | 2010 | Prehosp Disaster Med2010，25，4： | 1 |
| 15 | Synthesis of biological active octapetide similar to natural isoleucine agiotomin octapeptide显示文摘 | Irrine H P Hans S C Merlin F B | 1957 | J Am Chem Soc1957，79，： | 1 |
| 16 | Reduction by sonication of excess sludge production in a conventional activated sludge system: continuous flow and lab-scale reactor显示文摘 | VAXELAIRE S GONZE E MERLIN G | 2008 | Environmental Technology2008，29，12： | 1 |
| 17 | Software volumetric evaluation of doubling times for differentiating benign versus malignant pulmonary nodules 显示文摘 | Revel MP Merlin A Peyrard S | 2006 | Am J Roentgenol2006，187，1： | 1 |
| 18 | A primer on strategies for prevention and control of seasonal and pandemic influenza显示文摘 | Santibanez S Fiore A E Merlin T L | 2009 | Am J Public Health2009，992，： | 1 |
| 19 | Influence of SDZ - PSC 833 on daunorubicin intracellular accumulation in bone marrow specimens from patients with acute myeloid leukemia 显示文摘 | Merlin J L Guerci A P Marchal S | 1998 | Br J Haematol1998，103，2： | 1 |
| 20 | Severe hypertriglyceridae- mia in Type I1 diabetes: involvement of apoC-m Sst- I polymor- phism, LPL mutations and apo E3 deficiency 显示文摘 | Mar~ais C Bernard S Merlin M | 2000 | Diabetologia2000，43，11： | 1 |
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