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| 1 | 心电图有心肌缺血改变而冠状动脉造影正常者的冠状动脉血流的意义显示文摘目的 以计帧法评价心电图有心肌缺血改变而冠状动脉造影正常者的相关冠状动脉血流的意义。方法 静息心电图或踏板运动试验 (treadm ill test,TMT)有缺血改变 (连续 2个以上相关导联 ST段水平型或下斜型压低≥0 .0 5 m V或 T波深倒置 )但冠状动脉造影正常的 19例患者为缺血组。有心绞痛样症状而静息心电图、踏板运动试验以及冠状动脉造影正常的 5 2例为对照组。测定缺血相关性冠状动脉血流心肌梗死溶栓治疗试验 (thrombolysisin myocardial infarcton,TIMI)计帧值 (frame count,TIMI- FC)。结果 缺血组心电图示前壁心肌缺血者的冠状动脉前降支血流和下壁缺血者的右冠状动脉血流以及高侧壁缺血者的左回旋支血流的 TIMI- FC值显著大于对照组(分别为 35 .3± 16 .1vs19.9± 13.7,P<0 .0 5 ;38.9± 11.7vs2 1.7± 14 .1,P<0 .0 5及 35 .9± 16 .7vs.14 .1± 9.5 ,P<0 .0 1) ;TIMI- FC测定结果以 <2 7为血流正常 ,≥ 2 7为血流缓慢。血流缓慢 (slow coronary flow,SCF)者 2 2例 ,血流正常 (norm al coronary flow,NCF)者 4 9例。SCF者中心电图有缺血改变的患者 (15例 ,6 8.2 % )显著多于 NCF者中心电图有缺血的患者 (4例 ,8.2 % ) ;NCF者中心电图正常者 (4 5例 ,91.8% )显著多于 SCF者中心电图正常者(7例 , | 金振一 Bela Merkely 丁大植 崔兰 沈铁宽 | 2004 | 中国心血管杂志2004，9，3： | 4 |
| 2 | Blood flow restriction in human skeletal muscle during rest periods after high-load resistance training down-regulates miR-206 and induces Pax7显示文摘Backgroud:Blood flow re striction(BFR) with low-intensity re sistance training has been shown to result in hypertrophy of skeletal muscle.In this study,we tested the hypothesis that BFR during the rest periods between acute,high-intensity resistance exercise sessions(70% of 1 repetition maximum,7 sets with 10 repetitions) enhances the effects of the resistance training.Methods:A total of 7 healthy young men performed squats,and between sets BFR was carried out on one leg while the other leg served as a control.Because BFR was applied during rest periods,even severe occlusion pressure(approximately 230 mmHg),which almost completely blocked blood flow,was well-tolerated by the participants.Five muscle-specific microRNAs were measured from the biopsy samples,which were taken 2 h after the acute training.Results:Doppler data showed that the pattern of blood flow recovery changed significantly between the first and last BFR.microRNA-206 levels significantly decreased in the BFR leg compared to the control.The mRNA levels of RAC-β serine/threonine-protein kinase v22,nuclear re spiratory factor 1,vascular endothelial growth factor,lupus Ku autoantigen protein p70 genes(p <0.05),and paired box 7(p <0.01) increased in the BFR leg.The protein levels of paired box 7,nuclear respiratory factor 1,and peroxisome proliferator-activated receptor y coactivator 1α did not differ between the BFR leg and the control leg.Conclusion:BFR,during the rest periods of high-load resistance training,could lead to mRNA elevation of those proteins that regulate angiogenesis,mitochondrial biogenesis,and muscle hypertrophy and repair.However,BFR also can cause DNA damage,judging from the increase in mRNA levels of lupus Ku autoantigen protein p70. | Ferenc Torma Zoltan Gombos Marcell Fridvalszki Gergely Langmar Zsofia Tarcza Bela Merkely Hisashi Naito Noriko Ichinoseki-Sekine Masaki Takeda Zsolt Murlasits Peter Osvath Zsolt Radak | 2021 | Journal of Sport and Health Science2021，10，4： | 3 |
| 3 | Detection of crosslink with the comet assay in relationship to genotoxicity and cytotoxicity显示文摘 | Merk O Speit G | 1999 | Environmental and molecular mutagenesis1999，33，： | 2 |
| 4 | Stationary-frame generalized integrators for current control of active power filters with zero steady-state error for current harmonics of concern under unbalanced and distorted operating conditions显示文摘 | YUAN X M MERK W STEMMLER H | 2002 | IEEE Transaction on Industry Applications2002，38，2： | 1 |
| 5 | Endothelial microparticles affect angiogenesis in vitro:role of oxidative stress显示文摘 | Merks RM O'Riordan E | 2005 | Am J Physiol Heart Circ Physiol2005，289，： | 1 |
| 6 | Stationary frame gene- ralized integrators for current control of active power filters with zero steady state error for current harmonics of concern under unbalanced and distorted operating conditions显示文摘 | YUAN X MERK W STEMMLER H | 2002 | IEEE Trans on Industry Applications2002，38，2： | 1 |
| 7 | Identification of acute myeloid leukaemia associated microRNA expression patterns 显示文摘 | Isken F Steffen B Merk S | 2008 | Br J Haematol2008，140，2： | 1 |
| 8 | Deletions at chromosome 2q and 12p are early and freqauent molecular alterations in bronchial epithelium and NSCLC of long-term smokers显示文摘 | GREPMEIER U DIETMAIER W MERK J | 2005 | Int J Oncol2005，27，2： | 1 |
| 9 | Full-endoscopic interlaminar and transforaminal lumbar discectomy versus conventional microsurgical technique:a prospective, randomized, controlled study显示文摘 | Ruetten S Komp M Merk H Godolias G | 2008 | Spine2008，33，9： | 1 |
| 10 | Analysis of chromate-induced DNA-protein crosslinks with the comet assay显示文摘 | Merk O Reiser K Speit G | 2000 | Mutation Research2000，471，12： | 1 |
| 11 | Stationary- frame generalized integrators for current control of active power filters with zero steady-state error for current harmonics of concern under unbalanced and distorted operating conditions显示文摘 | YUAN X MERK W STEMMLER H | 2002 | IEEE Trans on IA2002，38，2： | 1 |
| 12 | Stationary- frame generalized integrators for current control of active power filters with zero steady-state error for current harmonics of concern under unbalanced and distorted operating conditions 显示文摘 | YUAN Xiaoming MERK W STEMMLER H | 2002 | IEEE Trans on Industry Application2002，38，2： | 1 |
| 13 | Use of newly developed instruments and endoscopes: full-endoscopic resection of lumbar disc herniations via the interlaminar and lateral trans- foraminal approach 显示文摘 | Ruetten S Komp M Merk H | 2007 | J Neurosurg Spine2007，6，6： | 1 |
| 14 | Use of newly developed instruments and endoscopes:full-endoscopic resection of lumbar disc herniations via the interlaminar and lateral transforaminal approach显示文摘 | Ruetten S Komp M Merk H | | 0，，06： | 1 |
| 15 | Macrophage migration inhibitory factor (MIF): a promising biomarker 显示文摘 | Grieb G Merk M Bernhagen J | 2010 | Drug News Perspect2010，23，： | 1 |
| 16 | STELCO-LAKE ERIE厂低硫钢的生产显示文摘Stelco Lake Erie厂(LEW)生产满足要求的低硫钢和超低硫钢。本文将详细讨论在炼钢实践中,LEW成功生产的抗氢质裂纹(HIC)等级为X52的ERW线材(其硫含量低于15ppm)以及HSLA类钢种(其硫含量低于50ppm)。 | Mark S. Fenton Ron H. Merk Blair A. Otterman | 2006 | 重钢技术2006，49，1： | 1 |
| 17 | The Golgi-associated protein p115 mediates the secretion of macrophage migration inhibitory factor 显示文摘 | Merk M Baugh J Zierow S | 2009 | J Immunol2009，182，11： | 1 |
| 18 | Identification of acute myeloid leukaemia associated microRNA expression patterns显示文摘 | Isken F Steffen B Merk S | 2008 | Br J Haematol2008，140，2： | 1 |
| 19 | Polysorbate 80 in medical products and nonimmunologic anaphylactoid reactions 显示文摘 | Coors EA Seybold H Merk HF | 2005 | Ann Allergy Asthma Immunol2005，95，6： | 1 |
| 20 | Neuman systems model in hol- land : an update显示文摘 | Merks A Verberk F de Kuiper M | 2012 | Nurs Sei Q2012，25，： | 1 |
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