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| 1 | Lymph node ratio and preoperative CA 19-9 levels predict overall survival and recurrence-free survival in patients with resected pancreatic adenocarcinoma显示文摘AIM:Clinicopathologic factors predicting overall survival (OS) would help identify a subset to benefit from adjuvant therapy. METHODS: One hundred and sixty-nine patients patients from 1984 to 2009 with curative resections for pancreatic adenocarcinoma were included. Tumors were staged by American Joint Committee on Cancer 7th edition criteria. Univariate and multivariable analyses were performed using Kaplan-Meier methodology or Cox proportional hazard models. Log-rank tests were performed. Statistical inferences were assessed by two-sided 5% significance level. RESULTS: Median age was 67.1 (57.2-73.0) years with equal gender distribution. Tumors were in the head (89.3%) or body/tail (10.7%). On univariate analysis, adjuvant therapy, lymph node (LN) ratio, histologic grade, negative margin status, absence of peripancreatic extension, and T stage were associated with improved OS. Adjuvant therapy, LN ratio, histologic grade, number of nodes examined, negative LN status, and absence of peripancreatic extension were associated with improved recurrence-free survival (RFS). On multivariable analysis, LN ratio and carbohydrate antigen (CA) 19-9 levels were associated with OS. LN ratio was associated with RFS. CONCLUSION: The LN ratio and CA 19-9 levels are independent prognostic factors following curative resections of pancreatic cancer. | Sabrina C Wentz Zhi-Guo Zhao Yu Shyr Chan-Juan Shi Kay Washington Nipun B Merchant Fen Xia A Bapsi Chakravarthy | 2012 | World Journal of Gastrointestinal Oncology2012，4，10： | 3 |
| 2 | Immunohistochemical analysis of the Wnt/β-catenin signaling pathway in pancreatic neuroendocrine neoplasms显示文摘AIM: To investigate the role of the Wnt/β-catenin pathway in pancreatic neuroendocrine neoplasms(PanN ENs). METHODS: Tissue microarrays containing 88 PanN ENs were immunohistochemically labeled with antibodies to β-catenin, E-cadherin, adenomatous polyposis coli(APC), chromogranin and synaptophysin. One case had only metastatic tumors resected, whereas others(n = 87) received pancreatectomy with or without partial hepatectomy. Pathology slides, demographic, clinicopathologic, and follow up data were reviewed. Patients' demographics, clinicopathologic features, and immunohistochemical results from 87 primary tumors were compared between patients with low stage(stage Ⅰ/Ⅱ) and high stage(stage Ⅲ/Ⅳ) tumors. In addition, correlation of immunohistochemical results from primary tumors with disease-specific survival(DSS) was evaluated. RESULTS: Strong membranous β-catenin staining in the primary tumor was observed in all 13 stage Ⅲ/Ⅳ Pan NENs as compared to 47%(35/74) of stage Ⅰ/Ⅱtumors(P < 0.01). However, the strong membranous β-catenin staining was unassociated with tumor grade or DSS. Decreased membranous β-catenin staining was associated with decreased membranous E-cadherin labeling. Nuclear β-catenin staining was seen in 15%(2/13) of stage Ⅲ/Ⅳ Pan NENs as compared to 0%(0/74) of stage Ⅰ/Ⅱ tumors(P = 0.02). The case with metastasectomy only also showed nuclear β-catenin staining. Two of the three cases with nuclear β-catenin staining were familial adenomatous polyposis(FAP) patients. Lack of APC expression was seen in 70%(57/81) of the cases, including the 3 cases with nuclear β-catenin staining. Expression of E-cadherin and APC in primary tumor was not correlated with tumor grade, tumor stage, or disease specific survival. CONCLUSION: The Wnt/β-catenin pathway was altered in some PanN ENs, but did not Impact DSS. PanN ENs in FAP patients demonstrated nuclear β-catenin accumulation and loss of APC. | Vivian Weiss Julie Dueber Jesse P Wright Justin Cates Frank Revetta Alexander A Parikh Nipun B Merchant Chanjuan Shi | 2016 | World Journal of Gastrointestinal Oncology2016，8，8： | 3 |
| 3 | The Effect of Microwave Radia tion on Coal Grindability 显示文摘 | Marland S Han B Merchant A | 2000 | Fuel2000，79，： | 1 |
| 4 | Ability of terminal QRS notching to dis- tinguish benign from malignant electrocardiographic forms of early repolarization显示文摘 | MERCHANT F M NOSEWORTHY P A WEINER R B | 2009 | Am J Cardiol2009，104，： | 1 |
| 5 | Anti-angiogenesis therapies:their potential in cancer management 显示文摘 | Eichholz A Merchant S Gaya AM | 2010 | Onco Target Ther2010，24，3： | 1 |
| 6 | On the estimation of T-wave ahernans using the spectral fast fourier transform method 显示文摘 | ARMOUNDAS A A MELA T MERCHANT F M | 2012 | Heart Rhythm2012，9，3： | 1 |
| 7 | Current and shot noise measurements in a carbon nanotube - based spin diode 显示文摘 | CHRISTOPHER A MERCHANT NINA M | 2009 | J Appl Phys2009，105，07： | 1 |
| 8 | Grain structure ofthin electrodeposited and rolled copper foils显示文摘 | Merchant H D Liu W C Giannuzzi L A | 2004 | MaterialsCharacterization2004，53，5： | 1 |
| 9 | Tuberculosis of the genitourinary system-urinary tract tuberculosis:Renal tuberculosis-Part I显示文摘 | Merchant S Bharati A Merchant N | 2013 | Indian J Radio Imaging2013，23，1： | 1 |
| 10 | Ex- perimental investigation of a high pressure ratio aspirated fan stage显示文摘 | Merchant A A Kerebrock J L Adamczk J J | 2005 | Journal of Turbo machinery2005，127，1： | 1 |
| 11 | Issues and challenges in the performance analysis of real disk arrays 显示文摘 | Varki E Merchant A Xu J | 2004 | IEEE Trans on Parallel and Distributed Systems2004，15，6： | 1 |
| 12 | Tuberculous chylous ascites:pathognomonic CTfindings显示文摘 | ANBARASU A UPADHYAY A MERCHANT S A | 1997 | Abdom Imaging1997，22，1： | 1 |
| 13 | Liver stiff- ness predicts clinical outcome in human immunodeficiency virus/hepatitis C virus -coinfected patients with compensa- ted liver cirrhosis显示文摘 | Merchante N Rivero -Juarez A Tellez F | 2012 | Hepatology2012，56，1： | 1 |
| 14 | Evidence of specialized leukocyte-vascular homing interactions at the maternal-fetal interface显示文摘 | Kruse A Merchant M J Hallmann R | 1999 | Euro J Immunol1999，29，： | 1 |
| 15 | Anti-angiogenesis therapies :their potential in cancer management 显示文摘 | Eichholz A Merchant S Gaya AM | 2010 | Onco Targets Ther2010，3，： | 1 |
| 16 | Folate,vitamin B6,and B12 intakes in relation to risk of stroke among men显示文摘 | He K Merchant A Rimm EB | 2004 | Stroke2004，35，1： | 1 |
| 17 | Synthesis of esters: development of the rate expression for the dowex 50 Wx8-400 catalyzed esterification of propionic acid with 1-propanol显示文摘 | Ali S H Tarakmah A Merchant S Q | 2007 | Chemical Engineering Science2007，62，12： | 1 |
| 18 | Impact Investing: A 21st Century Tool to Attractand Retain Donors 显示文摘 | Amy L Cheney C P A Kathryn E Merchant and Robert Killins Jr | 2012 | THE2012，，4： | 1 |
| 19 | Research and Control in Complex Organizations: A Overview 显示文摘 | MERCHANT K A SIMONS R | 1986 | Journal of Accounting Literature1986，48，2： | 1 |
| 20 | Evidence of specialized leukocyte-vascular homing interactions at the maternal/fetal interface显示文摘 | Kruse A Merchant MJ Hallmann R | 1999 | Eur J Immunol1999，29，4： | 1 |
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