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| 1 | Hypoxia-inducible factor 2α is a negative regulator of osteoblastogenesis and bone mass accrual显示文摘Osteoblasts,which are the bone-forming cells,operate in a hypoxic environment.The transcription factors hypoxia-inducible factor-1α(HIF1)and HIF2 are key mediators of the cellular response to hypoxia.Both are expressed in osteoblasts.HIF1 is known to be a positive regulator of bone formation.Conversely,the role of HIF2 in the control osteoblast biology is still poorly understood.In this study,we used mouse genetics to demonstrate that HIF2 is an inhibitor of osteoblastogenesis and bone mass accrual.Moreover,we provided evidence that HIF2 impairs osteoblast differentiation at least in part,by upregulating the transcription factor Sox9.Our findings constitute a paradigm shift,as activation of the hypoxia-signaling pathway has traditionally been associated with increased bone formation through HIF1.Inhibiting HIF2 could thus represent a therapeutic approach for the treatment of the low bone mass observed in chronic diseases,osteoporosis,or aging. | Christophe Merceron Kavitha Ranganathan Elizabeth Wang Zachary Tata Shreya Makkapati Mohd Parvez Khan Laura Mangiavini Angela Qing Yao Laura Castellini Benjamin Levi Amato J.Giaccia Ernestina Schipani | 2019 | Bone Research2019，7，1： | 7 |
| 2 | 神经电极-脑组织界面微动环境力学特性仿真显示文摘为了解决电极的长期寿命问题,采用有限元方法对电极-脑组织界面的微动进行静态分析和瞬态分析,基于商用电极A1x16-3-100-413进行建模,研究微动频率f和电极界面黏附状态对电极-脑组织界面力学状态的影响.结果表明,f对等效应力σ最大值有显著影响,高频率比低频率更不利于电极的长期稳定性,且存在临界值;f在20Hz左右时σ接近最大值,超过20Hz后f的影响减小;电极与脑组织之间的物理耦合度对界面力学状态有较大影响,增强电极和脑组织的黏附程度,可以有效减小微电极尖端和神经组织间的应力、应变以及分层,从而提高电极使用寿命. | 吴栋栋 张文光 MERCERON Gilles 罗云 | 2013 | 浙江大学学报(工学版)2013，47，2： | 5 |
| 3 | Existence of a deep subtidal stock of drifting Ulva in relation to intertidal algal mat developments 显示文摘 | Merceron M Morand P | 2004 | Journal of Sea Research2004，52，： | 1 |
| 4 | The intervertebral disc:from pathophysiology to tissue engineering显示文摘 | Clouet J Vinatier C Merceron C | 2009 | Joint Bone Spine2009，76，6： | 1 |
| 5 | The intervertebral disc:from pathophysiology to tissue engineering显示文摘 | Clouet J Vinatier C Merceron C | 2009 | Joint Bone Spine2009，76，6： | 1 |
| 6 | Adipose-derived mesenchymal stem cells and biomaterials for cartilage tissue engineering 显示文摘 | Merceron C Vinatier C Clouet J | 2008 | Joint Bone Spine:Revue du Rhumatismc2008，2008，06： | 1 |
| 7 | Adipose-derived mesenchymal stem cells and biomaterials for cartilage tissue engineering显示文摘 | Merceron C Vinatier C Clouet J | 2008 | Joint Bone Spine2008，75，6： | 1 |
| 8 | Adipose-derived mesen- chymal stem cells and biomaterials for cartilage tissue engineering 显示文摘 | Merceron C Vinatier C Clouet J | 2008 | Joint Bone Spine2008，75，6： | 1 |
| 9 | The intervertebral disc : frompathophysiology to tissue engineering显示文摘 | Clouet J Vinatier C Merceron C | 2009 | Joint Bone Spine2009，76，6： | 1 |
| 10 | Loss of HIF-1alpha in the notochord results in cell death and complete disappearance of the nucleus pulposus显示文摘 | Merceron C Mangiavini L Robling A | 2014 | Plo S one2014，9，11： | 1 |
| 11 | Differential effects of hypoxia on osteochondrogenic potential of human adipose-derived stem cells 显示文摘 | Merceron C Vinatier C Portron S | 2010 | Am J Physiol Cell Physiol2010，298，2： | 1 |
| 12 | Cartilage tissue engineering:towards a biomaterial-assistedmesenchymal stem cell therapy显示文摘 | Vinatier C Bouffi C Merceron C | | 0，，04： | 1 |
| 13 | X-ray diffraction on petrographic thin section with a linear localization detector显示文摘 | Rassineux F Beaufort D Merceron T | 1987 | Analusis1987，15，7： | 1 |
| 14 | Differential effects of hy- poxia on osteochondrogenic potential of human adipose-derived stem cells显示文摘 | Merceron C Vinatier C Portron S | 2010 | Am J Physiol Cell Physiol2010，298，2： | 1 |
| 15 | Adipose-derived mesenchymal stem cells and biomaterials for cartilage tissue engineering显示文摘 | Merceron C Vinatier C Clouet J | | 0，，： | 1 |
| 16 | The intervertebral disc: from patho-physiology to tissue engineering显示文摘 | Clouet J Vinatier C Merceron C | 2009 | Joint Bone Spine2009，76，： | 1 |
| 17 | Adiposc-derived mesenchymal stem cells and biomaterials for cartilage tissue engineering显示文摘 | Merceron C Vinatier C Clouet J | 2008 | Joint Bone Spine2008，75，6： | 1 |
| 18 | C - Phos- phanyl- C -chloroiminium Salts as Electrophilic Carbene Synthetic Equivalents 显示文摘 | Merceron N Baceiredo A Gornitzka | 2002 | Chemical Com- munications2002，7，19： | 1 |
| 19 | Coastal eutrophication and excessive growth of macroalgae显示文摘 | MORAND P MERCERON M | 2004 | Recent Research Developments in Environmental Biology2004，1，2： | 1 |
| 20 | Differential effects of hypoxia on osteochondrogenic potential of human adipose-derived stem cells显示文摘 | Merceron C Vinatier C Portron S | | 0，，： | 1 |
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