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| 1 | FAIR Principles:Interpretations and Implementation Considerations显示文摘The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in 2016.By intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital resources.This has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR solutions.However,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible implementations.Thus,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-usable.We introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR implementations.Any self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the future.Here,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle. | Annika Jacobsen Ricardo de Miranda Azevedo Nick Juty Dominique Batista Simon Coles Ronald Cornet Melanie Courtot Merce Crosas Michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara Magagna PeterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George Strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson Egon L.Willighagen Peter Wittenburg Marco Roos Barend Mons Erik Schultes | 2020 | Data Intelligence2020，2，1： | 26 |
| 2 | Error rate of multi-level rapid prototyping trajectories for pedicle screw placement in lumbar and sacral spine显示文摘ObjectiveFree 手小花梗螺丝钉放置有能与荧光检查,航行或一个其他的快速的原型练习指南模板被减少的小花梗穿孔的高发生。在我们为在腰部、骶的区域的小花梗螺丝钉放置的多水平模板的错误率是的学习, evaluated.MethodsA 盒子系列学习在 11 个病人上被执行。72 个螺丝钉用与选择激光 sintering 生产的 multilevel 练习指南模板被植入。根据外科手术前地定义的最佳的螺丝钉方向,螺丝钉误放的分析被执行。排水量,偏差和螺丝钉长度差别被测量。学习曲线也是 estimated.ResultsTwelve 螺丝钉(17%) 被放超过 3.125 从它在小花梗的中心的最佳的位置的公里。16 个螺丝钉(22%) 的尖端被错放超过 6.25 从预言的最佳的位置的公里。根据我们的预定义的目标, 19 个螺丝钉(26%) 不正确地被植入。在 10 种情况中,螺丝钉长度不正确地被选择:(1%) 1 拧紧太长,(13%) 9 是太短的。神经与血管的损害的临床的符号都没被观察。学习曲线是不足道显著(P = 0.129 ) 我们的学习,生产的过程和适用的多水平练习指南模板有的 .ConclusionIn 螺丝钉误放的 26% 机会。然而,那率不与小花梗穿孔发生和神经与血管的损害与一致。与到兼容研究的比较一起的这些事实使总结那可能多水平模板是令人满意地精确的并且与一个临床上无关的错误因素允许精确螺丝钉放置。因此,模板能潜在地为平淡的小花梗螺丝钉放置代表一个有用工具。 | Matjaz Merc Igor Drstvensek Matjaz Vogrin Tomaz Brajlih Tomaz Friedrich Gregor Recnik | 2014 | Chinese Journal of Traumatology2014，17，5： | 21 |
| 3 | Helicobacter pylori infection as a cause of iron deficiency anaemia of unknown origin显示文摘AIM: To assess the aetiological role of Helicobacter pylori (H. pylori) infection in adult patients with ironrefractory or iron-dependent anaemia of previously unknown origin. METHODS: Consecutive patients with chronic irondeficient anaemia (IDA) with H. pylori infection and a negative standard work-up were prospectively evaluated. All of them had either iron refractoriness or iron dependency. Response to H. pylori eradication was assessed at 6 and 12 mo from follow-up. H. pylori infection was considered to be the cause of the anaemia when a complete anaemia resolution without iron supplements was observed after eradication. RESULTS: H. pylori was eradicated in 88 of the 89 patients. In the non-eradicated patient the four eradicating regimens failed. There were violations of protocol in 4 patients, for whom it was not possible to ascertain the cause of the anaemia. Thus, 84 H. pylori eradicated patients (10 men; 74 women) were available to assess the effect of eradication on IDA. H. pylori infection was considered to be the aetiology of IDA in 32 patients (38.1%; 95%CI: 28.4%-48.8%). This was more frequent in men/postmenopausal women than in premenopausal women (75% vs 23.3%; P < 0.0001) with an OR of 9.8 (95%CI: 3.3-29.6). In these patients, anaemia resolution occurred in the first follow-up visit at 6 mo, and no anaemia or iron deficiency relapse was observed after a mean follow-up of 21 ± 2 mo. CONCLUSION: Gastric H. pylori infection is a frequent cause of iron-refractory or iron-dependent anaemia of previously unknown origin in adult patients. | Helena Monzón Montserrat Forné Maria Esteve Mercé Rosinach Carme Loras Jorge C Espinós Josep M Viver Antonio Salas Fernando Fernández-Baares | 2013 | World Journal of Gastroenterology2013，19，26： | 13 |
| 4 | Diagnosis and management of pericardial effusion显示文摘Pericardial effusion is a common finding in everyday clinical practice.The first challenge to the clinician is to try to establish an etiologic diagnosis.Sometimes,the pericardial effusion can be easily related to a known underlying disease,such as acute myocardial infarction, cardiac surgery,end-stage renal disease or widespread metastatic neoplasm.When no obvious cause is apparent,some clinical findings can be useful to establish a diagnosis of probability.The presence of acute inflammatory signs(chest pain,fever,pericardial friction rub) is predictive for acute idiopathic pericarditis irrespective of the size of the effusion or the presence or absence of tamponade.Severe effusion with absence of inflammatory signs and absence of tamponade is predictive for chronic idiopathic pericardial effusion,and tamponade without inflammatory signs for neoplastic pericardial effusion.Epidemiologic considerations are very important,as in developed countries acute idiopathic pericarditis and idiopathic pericardial effusion are the most common etiologies,but in some underdeveloped geographic areas tuberculous pericarditis is the leading cause of pericardial effusion.The second point is the evaluation of the hemodynamic compromise caused by pericardial fluid.Cardiac tamponade is not an'all or none'phenomenon,but a syndrome with a continuum of severity ranging from an asymptomatic elevationof intrapericardial pressure detectable only through hemodynamic methods to a clinical tamponade recognized by the presence of dyspnea,tachycardia,jugular venous distension,pulsus paradoxus and in the more severe cases arterial hypotension and shock.In the middle,echocardiographic tamponade is recognized by the presence of cardiac chamber collapses and characteristic alterations in respiratory variations of mitral and tricuspid flow.Medical treatment of pericardial effusion is mainly dictated by the presence of inflammatory signs and by the underlying disease if present.Pericardial drainage is mandatory when clinical tamponade is present.In the absence of clinical tamponade,examination of the pericardial fluid is indicated when there is a clinical suspicion of purulent pericarditis and in patients with underlying neoplasia.Patients with chronic massive idiopathic pericardial effusion should also be submitted to pericardial drainage because of the risk of developing unexpected tamponade.The selection of the pericardial drainage procedure depends on the etiology of the effusion.Simple pericardiocentesis is usually sufficient in patients with acute idiopathic or viral pericarditis.Purulent pericarditis should be drained surgically,usually through subxiphoid pericardiotomy. Neoplastic pericardial effusion constitutes a more difficult challenge because reaccumulation of pericardial fluid is a concern.The therapeutic possibilities include extended indwelling pericardial catheter,percutaneous pericardiostomy and intrapericardial instillation of antineoplastic and sclerosing agents.Massive chronic idiopathic pericardial effusions do not respond to medical treatment and tend to recur after pericardiocentesis, so wide anterior pericardiectomy is finally necessary in many cases. | Jaume Sagristà-Sauleda Axel Sarrias Mercé Jordi Soler-Soler | 2011 | World Journal of Cardiology2011，3，5： | 10 |
| 5 | Phakic intraocular lenses显示文摘 | Thomas Kohnen Daniel Kook Merce Morral Jose Luis Güell | 2010 | Journal of Cataract & Refractive Surgery2010，，12： | 2 |
| 6 | Binding mechanisms in selective laser sintering and selective laser melting 显示文摘 | Kruth J Mercelis P Vaerenbergh J | 2005 | Rapid Prototyping Journal2005，11，1： | 1 |
| 7 | Efficacy of standard(SLA)and modified sandblasted and acid-etched(SLActive)dental implantsin promoting immediate and/or early occlusal loading protocols:a systematic review of prospective studies显示文摘 | Chambrone L Shibli J Mercúrio C | 2015 | Clin Oral Implants Res2015，26，： | 1 |
| 8 | Binding mechanisms in selective laser sintering and selective laser melting显示文摘 | KRUTH J P MERCELIS P van VAERENBERGH J | 2005 | Rapid Prototyping Journal2005，11，1： | 1 |
| 9 | Aqueous and solid complexes of iron( Ⅲ )with hyaluronic acid显示文摘 | Merce A L Marques Carrera L C ASantos Romanholi L K | 2002 | J Inorg Biochem2002，89，34： | 1 |
| 10 | Evaluation of browning ef- fect on avocado puree 显示文摘 | ROBERT C S PEDRO E MERCE S | 2001 | Innov Food Sci Emerg Technoi2001，，1： | 1 |
| 11 | RANKL/OPG in primary cultures of osteoblasts from post-menopausal women. Differences between osteoporotic hip fractures and osteoarthritis显示文摘 | Mercè Giner M a José Rios M a José Montoya M a Angeles Vázquez Latifa Naji Ramón Pérez-Cano | 2008 | Journal of Steroid Biochemistry and Molecular Biology2008，，1： | 1 |
| 12 | Cervical pessary in pregnant women with a short cervix(PECEP):an open-label randomised controlled trial显示文摘 | Goya M Pratcorona L Merced C | 2012 | Lancet2012，379，： | 1 |
| 13 | MMP-9,TIMP-1 and inflam- matory ceils in sputum from COPD patients during exacerbation显示文摘 | Merce PF Shute JK Bhowmik A | 2005 | Respir Res2005，6，5： | 1 |
| 14 | High performance sputtered carbon coatings for wear resistant applications显示文摘 | Camino D Jones A H S Mercs D | 1999 | Vacuum1999，52，： | 1 |
| 15 | Are endometri- al parameters by three-dimensional ultrasound and power Doppler angiography related to in vitro fertilization/embryo transfer outcome?显示文摘 | MERCE L T BARCO M J BAU S | 2008 | Fertil Steril2008，89，1： | 1 |
| 16 | 显示文摘 | Merceds R Jose M Jordi F | 2000 | Thromb Haemost2000，84，2： | 1 |
| 17 | Genetic diversity of porcine sapoviruses in pigs from the Amazon region of Brazil显示文摘 | das Merces Hernandez J Stangarlin D C Siqueira J A M | 2014 | Archives of Virology2014，159，5： | 1 |
| 18 | A statistical approach for the integrated analysis of mine-induced seismicity and numerical stress estimates, a case study-Part-I: developing the relations显示文摘 | Merce R A Bawden W F | 2005 | International Journal of Rock Mechanics and Mining Sciences2005，42，1： | 1 |
| 19 | Are endometrial parameters bythree-dimensional ultrasound and power Doppler angiography relatedto in vitro fertilization/embryo transfer outcome显示文摘 | MERCE LT BARCO MJ BAU S | 2008 | Fertil Steril2008，89，1： | 1 |
| 20 | Binding mechanisms in selective laser sintering and selective laser melt- ing显示文摘 | J P Kruth P Mercelis J Van Vaerenbergh | 2005 | Rapid Prototyping Journal2005，11，1： | 1 |
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