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| 1 | 尿钠排泄、血压、心血管病与死亡率的关系:社区前瞻性流行病学队列研究显示文摘WHO建议人群钠摄人<2 g/d作为预防心血管病的措施之一,但这一目标在任何国家都没有实现。该建议主要基于短期血压试验的个体水平数据,没有来自随机试验或观察性研究的关于低钠摄入与降低心血管事件的数据。前瞻性城市农村流行病学研究目前正在21个国家进行。该文对其中18个国家的数据进行分析,其中包含了临床结果数据。 | Mente A O'Donnell M Rangarajan S McQueen M Dagenais G Wielgosz A Lear S Ah STL Wei L Diaz R Avezum A Lopez-Jaramillo P Lanas F Mony P Szuba A Iqbal R Yusuf R Mohammadifard N Khatib R Yusoff K Ismail N Gulec S Rosengren A Yusufali A Kruger L Tsolekile LP Chifamba J Dans A Alhabib KF Yeates K Teo K Yusuf S 刘莉 叶鹏 | 2018 | 中华高血压杂志2018，26，12： | 29 |
| 2 | Sorafenib inhibits growth and metastasis of hepatocellular carcinoma by blocking STAT3显示文摘AIM: To investigate the inhibitory role and the underlying mechanisms of sorafenib on signal transducer and activator of transcription 3 (STAT3) activity in hepatocellular carcinoma (HCC).METHODS: Human and rat HCC cell lines were treated with sorafenib. Proliferation and STAT3 dephosphorylation were assessed. Potential molecular mechanisms of STAT3 pathway inhibition by sorafenib were evaluated. In vivo antitumor action and STAT3 inhibition were investigated in an immunocompetent orthotopic rat HCC model.RESULTS: Sorafenib decreased STAT3 phosphorylationat the tyrosine and serine residues (Y705 and S727), but did not affect Janus kinase 2 (JAK2) and phosphatase shatterproof 2 (SHP2), which is associated with growth inhibition in HCC cells. Dephosphorylation of S727 was associated with attenuated extracellular signal-regulated kinase (ERK) phosphorylation, similar to the effects of a mitogen-activated protein kinase (MEK) inhibitor U0126, suggesting that sorafenib induced S727 dephosphorylation by inhibiting MEK/ERK signaling. Meanwhile, sorafenib could also inhibit Akt phosphorylation, and both the phosphatidylinositol-3-kinase (PI3K) inhibitor LY294002 and Akt knockdown resulted in Y705 dephosphorylation, indicating that Y705 dephosphorylation by sorafenib was mediated by inhibiting the PI3K/Akt pathway. Finally, in the rat HCC model, sorafenib signifi cantly inhibited STAT3 activity, reducing tumor growth and metastasis.CONCLUSION: Sorafenib inhibits growth and metastasis of HCC in part by blocking the MEK/ERK/STAT3 and PI3K/Akt/STAT3 signaling pathways, but independent of JAK2 and SHP2 activation. | Fang-Ming Gu, Quan-Lin Li, Qiang Gao, Jia-Hao Jiang, Xiao-Yong Huang, Jin-Feng Pan, Jia Fan, Jian ZhouFang-Ming Gu, Quan-Lin Li, Qiang Gao, Jia-Hao Jiang, Xiao-Yong Huang, Jin-Feng Pan, Jia Fan, Jian Zhou, Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Shanghai 200032, China Author contributions: Gu FM, Li QL and Gao Q contributed equally to this work Gu FM and Li QL performed the experi- ments and interpretation of the data and statistical analysis Zhou J and Gao Q contributed to the conception and design of the study Gu FM, Gao Q, Li QL and Zhou J wrote the manuscript Jiang JH, Huang XY, Pan JF and Fan J made substantial contri- bution to the design and conception of the study and interpreta- tion of data all authors read and approved the f inal manuscript. | 2011 | World Journal of Gastroenterology2011，17，34： | 18 |
| 3 | Influence of differenteCG doses on sexual receptivity and productivity of rabbit does显示文摘 | Theau-clément M Lebas F Boiti C | | 0，，： | 1 |
| 4 | Investigation of the effects of salinity and dietary protein level on growth and survival of pacific white shrimp, Litopenaeus vannamei显示文摘 | Perez-Velazquez M L Gonzalea-Felix M Jaimes Busta- mente F | 2007 | J World Aquacult Soc2007，38，4： | 1 |
| 5 | Incidence of cystoid macular edema after uncomplicated phacoemulsication 显示文摘 | Mentes J Erakgun T Afrashi F | 2003 | Ophthalmologica2003，217，6： | 1 |
| 6 | Gemcitabine in platin-paclitaxel resistant ovarian cancer显示文摘 | Coenen M Berteloot P A ment F el at | 2000 | Proc Annu Meet Am SocClinOncol2000，19，： | 1 |
| 7 | Evolution de la production d'anticorps anti-PMSG en fonction de la dose et du nombred injections显示文摘 | Theau-C1ément M Lebas F Drion P | 1998 | Relation avec la productivité deslapines 7es Journées de la Recherche Cunicole Lyon1998，，01： | 1 |
| 8 | Control of plant species richness and zonation of functional groups along a freshwater flooding gradient显示文摘 | Lenssen J Menting F van der Putten W | 1999 | Oikos1999，86，： | 1 |
| 9 | Relationship between thoracic hypokyphosis,lumbar lordosis and sagittal pelvic parameters in adolescent idiopathic scoliosis显示文摘 | Clément JL Geoffray A Yagoubi F | 2013 | Eur Spine J2013，22，11： | 1 |
| 10 | Incidence of cystoid macular edema after uncomplicated phacoemulsification 显示文摘 | Mentes J Erakgtm T Afrashi F Kerci G | 2003 | Ophthalmologica2003，217，6： | 1 |
| 11 | Developing a therapeutic range of adalimumab serum concentrations in management of psoriasis:a step toward personalized treatment显示文摘 | Menting S P Coussens E Pouw M F | 2015 | JAMADermatol2015，151，6： | 1 |
| 12 | Effects of Sediment Type and Water Level on Biomass Production of Wetland Plant Species显示文摘 | Lenssen J P M Menting F B J van der Putten W H | 1999 | Aquatic Botany1999，64，： | 1 |
| 13 | D6velopp ement folliculaire ovarien et ovulation chez les mammif'eres 显示文摘 | MONNIAUX D CARATY A CLE' MENT F | 2009 | INRA Prod Anita2009，22，2： | 1 |
| 14 | Effects of sedi- ment type and water level on biomass production of wetland plant species显示文摘 | Lenssen J P M Menting F B J Van der P | 1999 | Aquatic Botany1999，64，2： | 1 |
| 15 | Incidence of cystoid macu- lar edema after uncomplicated phacoemulsication 显示文摘 | Mentes J Erakgun T Afrashi F | 2003 | Ophthalmo- logica2003，217，6： | 1 |
| 16 | Ethnic variation in adiponectin and leptin levels and their association with adiposity and insulin resistance显示文摘 | Mente A Razak F Blankenberg S | 2010 | Diabetes Care2010，33，7： | 1 |
| 17 | Domain decomposition and skeleton programming with OCamlP31显示文摘 | Cle' ment F Martin V Vodicka A | 2006 | Parallel Computing2006，32，： | 1 |
| 18 | Incidence of cystoid macular edema after uncomplicated phacoemulsification显示文摘 | Mentes J Erakgun T Afrashi F Kerci G | 2003 | Ophthalmology2003，217，6： | 1 |
| 19 | Training-related brain plasticity in subjects at risk of developing Alzheimer's disease显示文摘 | Belleville S C1ément F Mellah S | 2011 | Brain2011，134，6： | 1 |
| 20 | Alexithymia and health behaviors in healthy male volunteers显示文摘 | Helrners K F Mente A | 1999 | J Psyehosom Res1999，47，6： | 1 |
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