|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Magnetic resonance elastography is accurate in detecting advanced fibrosis in autoimmune hepatitis显示文摘To assess the value of magnetic resonance elastography(MRE) in detecting advanced fibrosis/cirrhosis in autoimmune hepatitis(AIH).METHODS In this retrospective study, 36 patients(19 treated and 17 untreated) with histologically confirmed AIH and liver biopsy performed within 3 mo of MRE were identified at a tertiary care referral center. Liver stiffness(LS) with MRE was calculated by a radiologist, and inflammation grade and fibrosis stage in liver biopsy was assessed by a pathologist in a blinded fashion. Two radiologistsevaluated morphological features of cirrhosis on conventional magnetic resonance imaging(MRI). Accuracy of MRE was compared to laboratory markers and MRI for detection of advanced fibrosis/cirrhosis.RESULTS Liver fibrosis stages of 0, 1, 2, 3 and 4 were present in 4, 6, 7, 6 and 13 patients respectively. There were no significant differences in distribution of fibrosis stage and inflammation grade between treated and untreated patient groups. LS with MRE demonstrated stronger correlation with liver fibrosis stage in comparison to laboratory markers for chronic liver disease(r = 0.88 vs-0.48-0.70). A trend of decreased mean LS in treated patients compared to untreated patients was observed(3.7 k Pa vs 3.84 k Pa) but was not statistically significant. MRE had an accuracy/sensitivity/specificity/positive predictive value/negative predictive value of 0.97/90%/100%/100%/90% and 0.98/92.3%/96%/92.3%/96% for detection of advanced fibrosis and cirrhosis, respectively. The performance of MRE was significantly better than laboratory tests for detection of advanced fibrosis(0.97 vs 0.53-0.80, P < 0.01), and cirrhosis(0.98 vs 0.58-0.80, P < 0.01) and better than conventional MRI for diagnosis of cirrhosis(0.98 vs 0.78, P = 0.002).CONCLUSION MRE is a promising modality for detection of advanced fibrosis and cirrhosis in patients with AIH with superior diagnostic accuracy compared to laboratory assessment and MRI. | Jin Wang Neera Malik Meng Yin Thomas C Smyrk Albert J Czaja Richard L Ehman Sudhakar K Venkatesh | 2017 | World Journal of Gastroenterology2017，23，5： | 15 |
| 2 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 3 | Classification of gastric neuroendocrine tumors and its clinicopathologic significance显示文摘ClassificationofgastricneuroendocrinetumorsanditsclinicopathologicsignificanceYUJiYao1,WANGLuPing2,MENGYuHong1,HUMeng1,WA... | Yu, JY Wang, LP Meng, YH Hu, M Wang, JL Bordi, C | 1998 | World Journal of Gastroenterology1998，4，2： | 5 |
| 4 | Dopaminergic effects on in vitro osteogenesis显示文摘Multiple growth factors(e.g., BMP2, TGF-b1, FGF2) and isolated genes have been shown to improve osteoblastic proliferation and mineralization, advancing bone tissue engineering. Among these factors, both polydopamine(PDA) and dopamine(DA) monomer have recently been reported to increase osteoblast proliferation and mineralization in vitro. Although a well-characterized neurotransmitter, DA's role in the bone is unknown. We hypothesize that DA can directly act on osteoblasts, and examined whether osteoblasts express DA receptors that respond to exogenous DA. m RNAs and protein cell lysates were obtained from MC3T3-E1 cells during osteogenic differentiation phase. Reverse transcription polymerase chain reaction and western blot analysis were used to examine the expression of DA receptors, D1–D5. Dose-response effect and time course of DA treatment on cell proliferation, mineralization, and osteogenic differentiation were investigated at pre-determined days. Real-time PCR was performed to investigate whether DA affects osteogenic gene expression(ALP, BSP, OC, OSX, RUNX2, and Collagen1a2) with or without receptor antagonists(SCH233390 and GR103691). Two-way ANOVA was used for statistical analysis. All five DA receptors(D1, D2, D3, D4, and D5) m RNAs and proteins were expressed in MC3T3-E1 cells. DA treatment increased cell proliferation for up to 7 days(P, 0.05). Osteogenic mineralization was significantly greater in the DA-treated group than control group(P, 0.05). Finally, expression of all the osteogenic genes was inhibited by DA receptor antagonists for D1, D3, and D5. Our findings suggest that MC3T3-E1 osteoblasts express functional DA receptors that enhance proliferation and mineralization. PDA is not biologically inert and has important implications in orthopedic applications. Furthermore, osteoblast differentiation might be regulated by the nervous system, presumably during bone development, remodeling, or repair. | Dong Joon Lee Henry C Tseng Sing Wai Wong Zhengyan Wang Meng Deng Ching-Chang Ko | 2015 | Bone Research2015，3，3： | 3 |
| 5 | 非甾体抗炎药应用中,环氧合酶2、不对称二甲基精氨酸与心血管危害的关系显示文摘已有大规模、安慰剂对照试验确定了非甾体类抗炎药(nonsteroidal anti—inflammatory drugs,NSAIDs)具有心血管危害性:这归因于环氧合酶2(cyclooxygenase,COX-2)的心脏保护产物受到抑制,尤其是前列环素(prostacyclin,PG12)。NSAID降低心脏保护作用的另一种机制可能是通过增强肾脏中甲基精氨酸的形成来限制一氧化氮在整个脉管系统中的作用。 | Ricciotti E Castro C Tang SY Briggs WTE West JA Malik D Rhoades SD Meng H Li X Lahens NF Sparks JA Karlson EW Weljie AM Griffin JL FitzGerald GA6 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 3 |
| 6 | Influence of Eutrophication on the Distribution of Total Mercury and Methylmercury in Hydroelectric Reservoirs显示文摘 | Meng Bo Feng X B Chen C X Qiu G L Sommar J Guo Y N Liang P Wan Q | 2010 | EN2010，，5： | 2 |
| 7 | Cholesteryl ester transfer protein (CETP) expression protects against diet induced atherosclerosis in SR-BI deficient mice显示文摘 | HARDER C LAU P MENG A | 2007 | Arterioscler Thromb Vasc Biol2007，27，4： | 1 |
| 8 | Morphology and mechanical characteristics of compatibilized polyamide 6-liquid crystalline polymer composites 显示文摘 | Tjong S C Meng Y Z | 1997 | Polymer1997，38，18： | 1 |
| 9 | An overview of hydrogen production from biomass显示文摘 | Meng Ni Dennis Y C Leung Michael K H Leung Sumathy K | 2006 | Fuel Processing Technology2006，，87： | 1 |
| 10 | Metabolites of Colletotrichum gloeosporioides,an eddophytic fungus in Artemisia mongolica显示文摘 | Zou W X Meng J C Lu H | 2000 | J Nat Prod2000，63，： | 1 |
| 11 | Studies on catalytic pyrolysis of heavy oils: reaction behaviors and mechanistic pathways 显示文摘 | Meng X H Xu C M Gao J S | 2005 | Appl Catal A Gen2005，294，： | 1 |
| 12 | A lightweight network repair scheme for data collection applications in ZigBee WSNs显示文摘 | Meng S P Yu C S | 2009 | IEEE Communications Letters2009，，3： | 1 |
| 13 | How to Make Local Image Features More Efficient and Distinctive显示文摘 | Duan C Meng X | 2008 | IET Computer Vision2008，，2： | 1 |
| 14 | The structural and magnetic properties of Mn2 xFexNiGa Heusler alloys显示文摘 | LUO H Z MENG F B FENG Z Q LI Y X ZHU W WU G H ZHU X X JIANG C B XU H B | 2010 | J Appl Phys2010，107，01： | 1 |
| 15 | MicroRNA-125b down-regulation mediates endometrial cancer invasion by targeting ERBB2显示文摘 | Shang C Lu Y M Meng L R | 2012 | Med Sci Monit2012，18，4： | 1 |
| 16 | Connective tissue growth factor regulates the key events in tubular epithelial to myofibroblast transition in vitro显示文摘 | Zhang C Meng X Zhu Z | | 0，，： | 1 |
| 17 | Eosinophil apoptosis induced by fungal immunomodulatory peptide-fve via reducing IL-5alpha receptor显示文摘 | Hsieh C W LanJ L Meng Q | 2007 | J Formos Med Assoc2007，106，1： | 1 |
| 18 | Wear models and predictive equa- tions their form and content 显示文摘 | Meng H C Ludema K C | 1995 | Wear1995，181，183： | 1 |
| 19 | Long noncoding RNAs: novel insights into hepatocelluar carcinoma 显示文摘 | He Y Meng XM Huang C | 2014 | Cancer Lett2014，344，1： | 1 |
| 20 | A thermo-responsive affinity membrane with nano-structured pores and grafted poly(N-isopropylacrylamide) surface layer for hydrophobic adsorption显示文摘 | Meng T Xie R Chen Y C Cheng C J Li P F Ju X J Chu L Y | 2010 | Journal of Membrane Science2010，349，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员