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您的检索式：作者名="Mengdan Hu"
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| 1 | Human organoids in basic research and clinical applications显示文摘Organoids are three-dimensional(3D)miniature structures cultured in vitro produced from either human pluripotent stem cells(hPSCs)or adult stem cells(AdSCs)derived from healthy individuals or patients that recapitulate the cellular heterogeneity,structure,and functions of human organs.The advent of human 3D organoid systems is now possible to allow remarkably detailed observation of stem cell morphogens,maintenance and differentiation resemble primary tissues,enhancing the potential to study both human physiology and developmental stage.As they are similar to their original organs and carry human genetic information,organoids derived from patient hold great promise for biomedical research and preclinical drug testing and is currently used for personalized,regenerative medicine,gene repair and transplantation therapy.In recent decades,researchers have succeeded in generating various types of organoids mimicking in vivo organs.Herein,we provide an update on current in vitro differentiation technologies of brain,retinal,kidney,liver,lung,gastrointestinal,cardiac,vascularized and multi-lineage organoids,discuss the differences between PSC-and AdSC-derived organoids,summarize the potential applications of stem cell-derived organoids systems in the laboratory and clinic,and outline the current challenges for the application of organoids,which would deepen the understanding of mechanisms of human development and enhance further utility of organoids in basic research and clinical studies. | Xiao-Yan Tang Shanshan Wu Da Wang Chu Chu Yuan Hong Mengdan Tao Hao Hu Min Xu Xing Guo Yan Liu | 2022 | Signal Transduction and Targeted Therapy2022，7，6： | 10 |
| 2 | Modeling of gas porosity and microstructure formation during dendritic and eutectic solidification of ternary Al-Si-Mg alloys显示文摘A two-dimensional(2-D)multi-component and multi-phase cellular automaton(CA)model coupled with the Calphad method and finite difference method(FDM)is proposed to simulate the gas pore formation and microstructures in solidification process of hypoeutectic Al-Si-Mg alloys.In this model,the pore growth,and dendritic and eutectic solidification are simulated using a CA technique.To achieve the equilibrium among multiple phases during ternary Al-based alloy solidification,the phase transition thermodynamics and kinetics are evaluated by adopting the Calphad method.The diffusion equations of hydrogen and two solutes are solved by FDM.The developed CA-FDM coupled model can be used for simulating the evolution of gas microporosity and microstructures,involving dendrites and irregular binary and ternary eutectics,of ternary hypoeutectic Al-Si-Mg alloys.It has the capability of reproducing the interactions between the hydrogen microporosity formation and the growth of dendrites and eutectics,the competitive growth among the growing gas pores of different sizes,together with the time-evolving concentration fields of hydrogen and solutes.The simulated morphology of gas pore and microstructure has a good agreement with the experimental observation.The influences of the initial hydrogen concentration and cooling rate on the microporosity formation are investigated.It is found that the main portion of porosity formation occurs in the eutectic solidification stage through analyzing the profiles of porosity percentage and solid fraction varying with solidification time.The varying features of simulated porosity percentage,the maximum and average pores radii indicate that increasing initial hydrogen concentration promotes the formation of higher final porosity percentage and larger pores,while the size of gas pores will significantly reduce with increasing cooling rate,leading to a lower final porosity percentage. | Mengdan Hu Taotao Wang Hui Fang Mingfang Zhu | 2021 | Journal of Materials Science & Technology2021，，17： | 4 |
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