|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 荧光显像技术在消化外科中的应用进展显示文摘近红外荧光显像技术可运用特殊分子的荧光特性增强显示人体重要解剖结构和组织血流灌注。笔者总结荧光显像技术原理、常用荧光分子特性和荧光显像设备特点,探讨荧光显像技术在胃食管外科、肝胆外科、结直肠外科及腹膜恶性肿瘤等外科实践中的应用价值。笔者认为:通过特异性抗体偶联荧光分子探针检出肿瘤转移灶是荧光显像技术应用于消化外科的未来发展方向。 | Lucas Willian Thornblade Kurt Allan Melstrom Ali Zhumkhawala Yuman Fong | 2021 | 中华消化外科杂志2021，20，2： | 13 |
| 2 | Role of minimally invasive surgery for rectal cancer显示文摘Rectal cancer is one of the most common malignancies worldwide.Surgical resection for rectal cancer usually requires a proctectomy with respective lymphadenectomy(total mesorectal excision).This has traditionally been performed transabdominally through an open incision.Over the last thirty years,minimally invasive surgery platforms have rapidly evolved with the goal to accomplish the same quality rectal resection through a less invasive approach.There are currently three resective modalities that complement the traditional open operation:(1)Laparoscopic surgery;(2)Robotic surgery;and(3)Transanal total mesorectal excision.In addition,there are several platforms to carry out transluminal local excisions(without lymphadenectomy).Evidence on the various modalities is of mixed to moderate quality.It is unreasonable to expect a randomized comparison of all options in a single trial.This review aims at reviewing in detail the various techniques in regard to intra-/perioperative benchmarks,recovery and complications,oncological and functional outcomes. | Kurt A Melstrom Andreas M Kaiser | 2020 | World Journal of Gastroenterology2020，26，30： | 5 |
| 3 | Impact of RAS and BRAF mutations on carcinoembryonic antigen production and pattern of colorectal metastases显示文摘AIM: To investigate the impact of RAS and BRAF mutations on the pattern of metastatic disease and carcinoembryonic antigen(CEA) production.METHODS: In this retrospective study, we investigated the impact of RAS and BRAF mutational status on pattern of metastatic disease and CEA production. Only patients presenting with a newly diagnosed metastatic colorectal cancer(CRC) were included. Patients' characteristics, primary tumor location, site of metastatic disease and CEA at presentation were compared between those with and without RAS and BRAF mutations.RESULTS: Among 174 patients, mutations in KRAS, NRAS and BRAF were detected in 47%, 3% and 6% respectively. RAS mutations(KRAS and NRAS) were more likely to be found in African American patients(87% vs 13%; P value = 0.0158). RAS mutations were associated with a higher likelihood of a normal CEA(< 5 ng/mL) at presentation. BRAF mutations were more likely to occur in females. We were not able to confirm any association between mutational status and site of metastatic disease at initial diagnosis.CONCLUSION: No association was found between RAS and BRAF mutations and sites of metastatic disease at the time of initial diagnosis in our cohort. Patients with RAS mutations were more likely to present with CEA levels < 5 ng/mL. These findings may have clinical implications on surveillance strategies for RAS mutant patients with earlier stages of CRC. | may cho chie akiba cecilia lau david smith milhan telatar michelle afkhami stephen sentovich kurt melstrom marwan fakih | 2016 | World Journal of Gastrointestinal Oncology2016，8，1： | 3 |
| 4 | Laparoscopic versus open resection of gastric gastrointestinal stromal tu- mors显示文摘 | Melstrom LG Phillips JD Bentrem D J | 2012 | Am J Clin Oncol2012，35，5： | 1 |
| 5 | Overex-pression of 5-lipoxygenase in colon polyps and cancer and theeffect of 5-LOX inhibitors in vitro and in a murine model显示文摘 | Melstrom L G Bentrem D J Salabat M R | 2008 | Clin Cancer Res2008，14，20： | 1 |
| 6 | Neoadjuvant therapy for breast cancer显示文摘 | Liv SV Melstrom L Yao K | 2010 | J Surg Oncol2010，101，3： | 1 |
| 7 | Overexpression of 5-lipoxygenase in colon polyps and cancer and the effect of 5-LOX inhibitors in vitro and in a murine model显示文摘 | Melstrom LG Bentrem DJ Salabat MR | 2008 | Clin Cancer Res2008，14，20： | 1 |
| 8 | Neoadjuvant therapy for breast cancer显示文摘 | Liu S V Melstrom L Yao K | 2010 | J Surg Oneol2010，101，4： | 1 |
| 9 | Neoadjuvant therapy for breast cancer显示文摘 | Liu SV Melstrom L Yao K | 2010 | J Surg Oneol2010，101，4： | 1 |
| 10 | Laparoscopic ver- sus open resection of gastric gastrointestinal stromal tumors 显示文摘 | Melstrom LG Phillips JD Bentrem D J | 2012 | Am J Clin Oncol2012，35，5： | 1 |
| 11 | Mechanisms of skeletal muscle degradation and its therapy in cancer cachexia显示文摘 | Melstrom LG Melstrom KA Jr Ding XZ | 2007 | Histol Histopathol2007，22，7： | 1 |
| 12 | Valuing Historic Bat- tlefieldsjan Application of the Travel Cost Method to Three American Civil War battle fields显示文摘 | RICHARD T MELSTROM | 2013 | Jour- nal of Cultural Economic2013，，： | 1 |
| 13 | Overexpression of 5 - Lipoxygenase in colon polyps and cancer and the effect of 5 - LOX inhibitors in vitro and in a murine model 显示文摘 | Melstrom LG Bentrem DJ Salabat MR | 2008 | Clin Cancer Res2008，14，20： | 1 |
| 14 | Neoadjuvant therapy for breast cancer显示文摘 | Liu SV Melstrom L Yao K | 2010 | J Surg Oncol2010，101，4： | 1 |
| 15 | Apigenin Inhihits the GLUT-1 Glucose Transporter and the Phosphoinositide 3-Kinase/Akt Pathway in Human Pancreatic Cancer Cells显示文摘 | Melstrom L G Salabat M R Ding Xian-Zhong | | 0，，04： | 1 |
| 16 | Mechanisms of skeletal muscle degradation and its therapy in cancer cachexia 显示文摘 | Melstrom L G Melstrom K A Jr Ding X Z | 2007 | Histol Histopathol2007，22，7： | 1 |
| 17 | Apigenin Down-Regulates the Hypoxia Response Genes:HIF-1 α,GLUT-1,and VEGF in Human Pancreatic Cancer Cells显示文摘 | Melstrom L G Salabat M R | | 0，，： | 1 |
| 18 | Laparoscopicversus open resection of gastric gastrointestinal stromal tumors显示文摘 | Melstrom LG Phillips JD Bentrem DJ | 2012 | Am J Clin Oncol2012，35，： | 1 |
| 19 | Mecha- nisms of skeletal muscle degradation and its therapy in cancer cachexia显示文摘 | Melstrom LG Melstrom KA Jr Ding XZ | 2007 | Histol Histopathol2007，22，7： | 1 |
| 20 | Neoadjuvant therapy for breast cancer 显示文摘 | Liu SV Melstrom L Yao K | 2010 | Surg 0ncol2010，101，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员