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14篇 您的检索式：作者名="Mello MF"

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		题名	作者	年代	出处	被引量
	1	Epidermal growth factor receptor and K-Ras in non-small cell lung cancer-molecular pathways involved and targeted therapies显示文摘Lung cancer is currently the leading cause of cancer death in Western nations.Non-small cell lung cancer(NSCLC)represents 80%of all lung cancers,and adenocarcinoma is the predominant histological type.Despite the intensive research carried out on this field and therapeutic advances,the overall prognosis of these patients remains unsatisfactory,with a 5-year overall survival rate of less than 15%.Nowadays,pharmacogenetics and pharmacogenomics represent the key to successful treatment.Recent studies suggest the existence of two distinct molecular pathways in the carcinogenesis of lung adenocarcinoma:one associated with smoking and activation of the K-Ras oncogene and the other not associated with smoking and activation of the epidermal growth factor receptor(EGFR).The K-ras mutation is mainly responsible for primary resistance to new molecules which inhibit tyrosine kinase EGFR(erlotinib and gefitinib)and most of the EGFR mutations are responsible for increased tumor sensitivity to these drugs.This article aims to conduct a systematic review of the literature regarding the molecular pathways involving the EGFR,K-Ras and EGFR targeted therapies in NSCLC tumor behavior.	Ramon Andrade de Mello Dania Sofia Marques Rui Medeiros António MF Araújo	2011	World Journal of Clinical Oncology2011，2，11：	16
	2	Update on stress and depression: the role of the hypothalamic-pituitaryadrenal (HPA) axis显示文摘	Mello AA Mello MF Carpenter LL	2003	Rev Bras Psiquiatr2003，25，4：	1
	3	A systematic review on the effectiveness of cognitive behavioral therapy for posttraumatic stress disorder显示文摘	Mendes DD Mello MF Ventrua P	2008	Int J Psychiatry Med2008，38，3：	1
	4	A new era in noninvasive prenatal testing显示文摘	Morain S Greene MF Mello MM	2013	N Engl J Med2013，369，：	1
	5	A randomized controlled trial comparing moclobemide and moclobemide plus interpersonal psychotherapy in the treatment of dysthyrnic disorder显示文摘	de MELLO MF MYCZCOWISK LM MENEZES PR	2001	J Psychother Pract Res2001，10，2：	1
	6	A new era in noninvasive prenatal testing显示文摘	Morain S Greene MF Mello MM	2013	N Engl J Med2013，369，6：	1
	7	Serum levels of nerve growth factor (NGF) in patients with major depression disorder and suicide risk 显示文摘	Wiener CD Mello FS Pedrotti MF	2015	J Affect Disord2015，184，16：	1
	8	A new era in noninvasive prenatal testing显示文摘	Morain S Greene MF Mello MM	2013	N Engl J Med2013，369，6：	1
	9	Effects of acute exercise on angiotensin I-converting enzyme(ACE)activity in horses显示文摘	De Mello Costa MF Anderson GA Davies HM	2012	Equine Vet J2012，44，4：	1
	10	Update on stress and depression: the role of the hypothalamic--pituitary--adrenal(HPA) axis显示文摘	Mello AA Mello MF Carpenter LL	2003	Rev Bras Psiquiatr2003，25，4：	1
	11	A systematic review of research findings on the efficacy of interpersonal therapy for depres- sive disorders显示文摘	de Mello MF de Jesus Mari J Bacaltehuk J	2005	Eur Arch Psychiatry Clin Neurosei2005，255，2：	1
	12	The role of early parental bonding in the development of psychiatric symptoms in adulthood显示文摘	Lima AR Mello MF de Jesus Mari J	2010	Current Opinion in Psychiatry2010，23，4：	1
	13	A new era in noninvasiveprenatal testing显示文摘	Morain S Greene MF Mello MM	2013	N Engl J Med2013，369，：	1
	14	社会经济地位,而不是非洲血统的基因组,与血压相关:Bambui-Epigen(巴西)老龄化队列研究显示文摘该研究旨在确定非洲基因组起源对巴西以社区为基础的多种族老年人群基线和11年血压变化的作用。方法:纳入随访11年的Bambui-Epigen(巴西)老龄化队列研究中的≥60岁受试者1272人的资料,观察指标为收缩压、舒张压和高血压控制率。潜在的混杂因素包括人口学特征、社会经济地位(教育和家庭收入)、健康指标(吸烟、久坐的生活方式、高密度脂蛋白胆固醇、腰围、糖尿病和心血管病等)、抗高血压药物的使用。	刘莉叶鹏 Lima-Costa MF Mello Mambrini JV Leite ML Peixoto SV Firmo JO Loyola Filho AI Gouveia MH Leal TP Pereira AC Macinko J Tarazona-Santos E	2016	中华高血压杂志2016，24，2：	0

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