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| 1 | Type 2 diabetes and quality of life显示文摘It is true that a primary goal of diabetes early diagnosis and treatment is quality of life(QoL). The term QoL is still confusing but it is agreed that it composes of four components:The physical component, mental, cogitative component, psychological and social component. Many articles have been written addressing those four components. During the last five years 15500 articles and reviews have been written addressing diabetes and coronary arterial disease, 16100 addressing diabetes and renal function, 28900 addressing diabetes and retinopathy, 16800 addressing diabetic foot ulcers and other 26300 addressing diabetic neuropathy. Moreover 17200 articles are dealing with diabetic sexual dysfunction, 24500 with the correlation of diabetes and depression 17500 about diabetes and dementia, only 1 about diabetes and family functioning and 1950000 about diabetes and QoL, indicating the worldwide interest. In order to confront this metabolic anomaly and its consequences, researchers developed numerous generic and disease specific psychometric tools. With the aid of those psychometric tools the scientific community has started to realize the gruesome effect of diabetes on patients' lives. Diabetic's QoL becomes worse when complications start to develop or comorbidities coexist. Dominant amongst complications, in health-related quality of life(HRQoL) lowering, but not related to risk factors(genetic, the weight of birth, or others) is coronary arterial disease followed by renal failure, blindness, and the combination of micro-and macrovascular complications and in some studies by sexual dysfunction. Moreover many are the comorbidities which deteriorate further the effect of diabetes in a patient life. Among them obesity, hypertension, dyslipidemia, depression, arthritis are the most common. Most intriguing field for research is the interaction of diabetes and depression and in some cases the progression to dementia. Many aspects and combinations of actions are under researchers' microscope regarding the improvement of HRQoL scores. Until now, the studies performed, have demonstrated little to moderate benefit. More of them are needed to draw safe conclusions on the topic of the best combination of actions to optimize the HRQoL scores. | Aikaterini Trikkalinou Athanasia K Papazafiropoulou Andreas Melidonis | 2017 | World Journal of Diabetes2017，8，4： | 7 |
| 2 | Effects of antidiabetic drugs on epicardial fat显示文摘Epicardial adipose tissue is defined as a deposit of adipocytes with pathophysiological properties similar to those of visceral fat, located in the space between the myocardial muscle and the pericardial sac. When compared with subcutaneous adipose tissue, visceral adipocytes show higher metabolic activity, lipolysis rates, increased insulin resistance along with more steroid hormone receptors. The epicardial adipose tissue interacts with numerous cardiovascular pathways via vasocrine and paracrine signalling comprised of pro-and anti-inflammatory cytokines excretion. Both the physiological differences be-tween the two tissue types, as well as the fact that fat distribution and phenotype, rather than quantity, affect cardiovascular function and metabolic processes, establish epicardial fat as a biomarker for cardiovascular and metabolic syndrome. Numerous studies have underlined an association of altered epicardial fat morphology, type 2 diabetes mellitus(T2 DM) and adverse cardiovascular events. In this review, we explore the prospect of using the epicardial adipose tissue as a therapeutic target in T2 DM and describe the underlying mechanisms by which the antidiabetic drugs affect the pathophysiological processes induced from adipose tissue accumulation and possibly allow for more favourable cardiovascular outcomes though epicardial fat manipulation. | Eleni Xourgia Athanasia Papazafiropoulou Andreas Melidonis | 2018 | World Journal of Diabetes2018，9，9： | 5 |
| 3 | Circulating microRNAs as biomarkers for diabetic neuropathy: A novel approach显示文摘Oxidative stress stemming from tissue exposure to constant hyperglycemia is one of the major pathogenetic pathways of diabetic macro-and microvascular complications. Diabetic polyneuropathy, commonly manifesting as distal,symmetrical sensorimotor polyneuropathy, is characterized by progressive severity of symptoms, with rates analogous to the quality of glycemic control achieved by the patients and physicians. Palliative care with analgesics and aggressive glycemic control often improve quality of life in the absence of causative treatment. Currently, there is a growing body of evidence indicating the role of microRNAs in the pathogenesis of diabetic complications, with emphasis on diabetic nephropathy and neuropathy. Therefore, in this review, we aim to explore the role of microRNAs and their polymorphisms in the pathophysiology of diabetic polyneuropathy, as well as, the possibility of novel diagnostic and therapeutic applications by epigenetic profiling and manipulation. | Eleni Xourgia Athanasia Papazafiropoulou Andreas Melidonis | 2018 | World Journal of Experimental Medicine2018，8，3： | 4 |
| 4 | Comparison of coronary collateral circulation in diabetic and nondiabetic patients suffering from coronary artery disease显示文摘 | Melidonis A Tournis S Kouvaras G | 1999 | Clin Cardiol1999，22，7： | 1 |
| 5 | Impact of the metabolic syndrome and its components combinations on arterial stiffness in Type 2 diabetic men显示文摘 | Levisianou D Melidonis A Adamopoulou E | 2009 | Int Angiol2009，28，6： | 1 |
| 6 | Angiographicstudy of coronary artery disease in diabetic patients incomparisonwith nondiabetic patients显示文摘 | Melidonis A Dimopoulos V Lempidakis E | 1999 | Angiology1999，50，12： | 1 |
| 7 | Angiographic study of coronary artery disease in diabetic patients in comparison with nondiabetic patients显示文摘 | Melidonis A Dimopoulos V Lempidakis E | | 0，，12： | 1 |
| 8 | Comparison of coronary collateral cireulation in diabetie and nondiabetie patient ssuffering from coronary artery disease显示文摘 | Melidonis A Tournis S Kouvaras G | 1999 | Clin Cardiol1999，22，7： | 1 |
| 9 | Toll/interleukin-1 receptor member ST2 exhibits higher soluble levels in type 2 diabe- tes,especially when accompanied with left ventricular diastolic dys- function 显示文摘 | Fousteris E Melidonis A Panoutsopoulos G | 2011 | Cardiovasc Diabeto12011，10，： | 1 |
| 10 | Toll/interleukin-1 receptor member ST2 exhibits higher soluble levels in type 2diabetes,especially when accompanied with left ventricular diastolic dysfunction显示文摘 | Fousteris E Melidonis A Panoutsopoulos G | 2011 | Cardiovasc Diabetol2011，10，： | 1 |
| 11 | Angiographic stuby of coronary artery disease in diabetic patients in comparison with nondiabetic patients 显示文摘 | Melidonis A Dimopoulos V Lempidakis E | 1999 | Angiology1999，50，： | 1 |
| 12 | Angiographic study of coronary artery disease in diabetic patients in comparison with nondiabetic patients显示文摘 | Melidonis A Dimopoulos V Lempidakis E | 1999 | Angiology1999，50，： | 1 |
| 13 | The role of strict metabolic control by insulin infusion on fibrinolytic profile during an acute coronary event in diabetic patients显示文摘 | Melidonis A Stefanidis A Tournis S | 2000 | Clin Cardiol2000，23，： | 1 |
| 14 | Comparison of coronary collateral circulation in diabetic and nondiabetie patients suffering from coronary artery disease 显示文摘 | Melidonis A Toumis S Kouvaras G | 1999 | Clin Cardiol1999，22，： | 1 |
| 15 | Angiographic study of coronary artery disease in diabetic patients in comparison with nondiabetic patients显示文摘 | Melidonis A Dimopoulos V Lempidakis E | 1999 | Angiology1999，50，： | 1 |
| 16 | Impact of the metabolic syndrome and its com-ponents combinations on arterial stifmess in Type 2 diabetic men显示文摘 | Levisianou D Melidonis A Adamopoulou E | 2009 | Int Angiol2009，28，6： | 1 |
| 17 | Comparison of coronary collateral circulation in diabetic and nondiabetic patients suffering from coronary disease显示文摘 | MELIDONIS A TOURNIS S KOUVARAS G | 1999 | Clin Cardiol1999，22，7： | 1 |
| 18 | Diabetes mellitus is associated with increased intramyocellular triglyceride, but not diglyceride, content in obese humans显示文摘 | Costas A. Anastasiou Stavros A. Kavouras Yannis Lentzas Afrodite Gova Labros S. Sidossis Adreas Melidonis | 2009 | Metabolism2009，，11： | 1 |
| 19 | Comparison of coronary collateral circulation in diabetic and nondiabetic patients suffering from coronary artery disease显示文摘 | Melidonis A Tournis S Kouvaras G | 1999 | Clin Cardiol1999，22，7： | 1 |
| 20 | Comparison of coronary collateral circulation in diabetic andnondiabetic patientssuffering from coronary artery disease显示文摘 | MELIDONIS A TOURNIS S KOUVARAS G | 1999 | Clin Cardiol1999，22，： | 1 |
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