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| 1 | Potential role of killer immunoglobulin receptor genes among individuals vaccinated against hepatitis B virus in Lebanon显示文摘AIM To explore the role of killer immunoglobulin receptor(KIR) genes in responsiveness or non-responsiveness to vaccination against hepatitis B virus.METHODS We recruited 101 voluntary participants between March 2010 and December 2011. Sera samples from vaccinated and non-vaccinated participants were tested for the presence of anti-HBs antibodies as a measure of protection against hepatitis B, hepatitis B surface antigen and hepatitis B core antibody as indicators ofinfection by enzyme-linked immunosorbent assay. KIR gene frequencies were determined by polymerase chain reaction.RESULTS Sera samples from 99 participants were tested for the levels of anti-HBs as an indicator of protection(≥ 10 mI U/ml) following vaccination as defined by the World Health Organization international reference standard. Among the vaccinated participants, 47%(35/74) had anti-HBs titers above 100 mI U/ml, 22%(16/74) had antiHBs ranging between 10-100 mI U/ml, and 20%(15/74) had values of less than 10 mI U/ml. We report the lack of significant association between the number of vaccine dosages and the titer of antibodies among our vaccinated participants. The inhibitory KIR2Dl1, KIR2Dl4, KIR3Dl1, KIR3Dl2, and KIR3 Dl were detected in more than 95%, whereas KIR2Dl2, KIR2Dl3, KIR2Dl5(KR2Dl5A and KIR2Dl5B) were expressed in 56%, 84% and 42%(25% and 29%) of participants, respectively. The observed frequency of the activating KIR genes ranged between 35% and 55% except for KIR2DS4, detected in 95% of the study participants(40.6% 2DS4*001/002; 82.2% 2DS4*003/007). KIR2DP1 pseudogene was detected in 99% of our participants, whereas KIR3DP*001/02/04 and KIR3DP1*003 had frequencies of 17% and 100%, respectively. No association between the frequency of KIR genes and anti-HBs antibodies was detected. When we compared the frequency of KIR genes between vaccinated individuals with protective antibodies titers and those who lost their protective antibody levels, we did not detect a significant difference. KIR2Dl5 B was significantly different among different groups of vaccinated participants(group Ⅰ > 100 mI U/ml, group Ⅱ 10-100 mI U/ml, group Ⅲ < 10 mI U/ml and group Ⅳ with undetectable levels of protective antibodies). CONCLUSION To our knowledge, this is the first study screening for the possible role of KIR genes among individuals vaccinated against hepatitis B virus(HBV). Our results can be used to design larger studies to better understand the role of KIR genes in protection against or susceptibility to HBV post vaccination. | Nada M Melhem Rami A Mahfouz Khalil Kreidieh Rabab Abdul-Khalik Rolla El-Khatib Reem Talhouk Umayya Musharrafieh Ghassan Hamadeh | 2016 | World Journal of Hepatology2016，8，29： | 2 |
| 2 | Administration of Glucocorticoids to Ovarian Cancer Patients Is Associated with Expression of theAnti-apoptotic Genes SGK1 and MKP1/DUSP1 in OvarianTissues显示文摘 | Melhem A Yamada S D Fleming G F | 2009 | Clin Cancer Res2009，15，9： | 1 |
| 3 | Administration of glucocorticoids to ovarian cancer patients is associated with expression of the anti-apoptotic genes SGK1 and MKP1/DUSP1 in ovarian tissues显示文摘 | Melhem A Yamada SD Fleming GF | 2009 | Clin Cancer Res2009，15，9： | 1 |
| 4 | Nitric oxide in diabetic nephropathy显示文摘 | Craven P A DeRubektis F R Melhem M | 1997 | Kidney Int Suppl1997，52，60： | 1 |
| 5 | Anti-fibrotic activity of NK cells in experimental liver injury through killing of activated HSC显示文摘 | Melhem A Muhanna N Bishara A | | 0，，： | 1 |
| 6 | Administration of glucocorticoids to ovarian cancer patients is associated with expression of the anti-apoptotie genes SGK1 and MKP1/DUSP1 in ovarian tissues 显示文摘 | Melhem A Yamada SD Fleming GF | 2009 | Clin Cancer Res2009，15，9： | 1 |
| 7 | 显示文摘 | Melhem G A | 1989 | Fluid Phase Equilibria1989，47，： | 1 |
| 8 | Kinetics of the reactions of ethylene oxide with water and ethylene glycols显示文摘 | Georges A Melhem Arturo Gianetto Marc E levin | 2001 | Process Safety Progress2001，20，4： | 1 |
| 9 | Response prediction of concrete beams reinforced with FRP bars 显示文摘 | Rasheed H A Nayal R Melhem H | 2004 | Composite Structures2004，65，2： | 1 |
| 10 | Analysis of MRI Patterns Aids Prediction of Progression in X-linked Adrenoleukodystrophy 显示文摘 | Loes DJ Fatemi A Melhem ER | 2003 | Neurology2003，61，3： | 1 |
| 11 | A detailed method for estimating mixture flammability limits using chemical equilibrium 显示文摘 | Melhem G A | 1997 | AIChE Process Safety Progress1997，16，4： | 1 |
| 12 | Administration of glucocortieoids to ovarian cancer patients is associated with ex- pression of the anti-apoptotic genes SGK1 and MKPI/DUSP1 in ovarian tissues 显示文摘 | Melhem A Yamada SD Fleming GF | 2009 | Clin Cancer Res2009，15，9： | 1 |
| 13 | Nitric oxide in diabetic nephropathy显示文摘 | Craven P A DeRubektis F R Melhem M | 1997 | Kidney Int Suppl1997，52，60： | 1 |
| 14 | Use of the VITEK 2 system to identify and test the antifungal susceptibility of clinically relevant yeast species显示文摘 | Melhem MS Bertoletti A Lucca HR | 2013 | Braz J Microbiol2013，44，4： | 1 |
| 15 | International symposium on runaway reactions, pressure relief design and effluent handling 显示文摘 | Fisher H G Melhem G A | 1998 | Chem Eng Progr1998，67，6： | 1 |
| 16 | Anti -fibrotic actiVity of NK ceUs in experimental liver injury through killing of activated Hsc 显示文摘 | Melhem A Muhallna N Bishara A | 2006 | J Hepatol2006，45，1： | 1 |
| 17 | A detailed method for estimating mixture flammabili- ty limits using chemical equilibrium 显示文摘 | Melhem G A | 1997 | Process Safety Progress1997，16，4： | 1 |
| 18 | A detailed method for estimating mixture flammability limits using chemical equilibrium显示文摘 | Melhem G A | 1997 | Process Safety Progress1997，16，： | 1 |
| 19 | Analysis of MRI patterns aids prediction of progression in X-linked adrenoleukodystrophy显示文摘 | Fatemi A Melhem ER | 2003 | Neurology2003，61，3： | 1 |
| 20 | Analysis of MRI patterns aids prediction of progression in X - linked adrenoleukodystrophy显示文摘 | Loes DJ Fatemi A Melhem ER | 2003 | Neurology2003，61，3： | 1 |
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