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| 1 | Specifc inflammatory osteoclast precursors induced during chronic inflammation give rise to highly active osteoclasts associated with inflammatory bone loss显示文摘Elevated osteoclast(OC)activity is a major contributor to inflammatory bone loss(IBL)during chronic inflammatory diseases.However,the specific OC precursors(OCPs)responding to inflammatory cues and the underlying mechanisms leading to IBL are poorly understood.We identified two distinct OCP subsets:Ly6C^(hi)CD11b^(hi) inflammatory OCPs(iOCPs)induced during chronic inflammation,and homeostatic Ly6C^(hi)CD11b^(lo)OCPs(hOCPs)which remained unchanged.Functional and proteomic characterization revealed that while iOCPs were rare and displayed low osteoclastogenic potential under normal conditions,they expanded during chronic inflammation and generated OCs with enhanced activity.In contrast,hOCPs were abundant and manifested high osteoclastogenic potential under normal conditions but generated OCs with low activity and were unresponsive to the inflammatory environment.Osteoclasts derived from iOCPs expressed higher levels of resorptive and metabolic proteins than those generated from hOCPs,highlighting that different osteoclast populations are formed by distinct precursors.We further identified the TNF-αand S100A8/A9 proteins as key regulators that control the iOCP response during chronic inflammation.Furthermore,we demonstrated that the response of iOCPs but not that of hOCPs was abrogated in tnf-α^(-/-)mice,in correlation with attenuated IBL.Our findings suggest a central role for iOCPs in IBL induction.iOCPs can serve as potential biomarkers for IBL detection and possibly as new therapeutic targets to combat IBL in a wide range of inflammatory conditions. | Yaron Meirow Milena Jovanovic Yuval Zur Juliana Habib Daniele Filippo Colombo Nira Twaik Hadas Ashkenazi-Preiser Kerem Ben-Meir Ivan Mikula Jr. Or Reuven Guy Kariv Leonor Daniel Saja Baraghithy Yehuda Klein Jeroen Krijgsveld Noam Levaot Michal Baniyash | 2022 | Bone Research2022，10，3： | 2 |
| 2 | Pregnancy after transplantation of cryopreserved ovarian tissue in a patient with ovarian failure after chemotherapy 显示文摘 | Meirow D Levron J Eldar-Geva T | 2005 | N Engl J Med2005，353，： | 1 |
| 3 | Evaluat ion and treatm entof iatrogen ic ureteral in juries during obstetric and gynecological operationsfor nonm al ignan t cond iy ions显示文摘 | Meirow D Moriel EZ Zilberman M | 1994 | J Coll Surg1994，178，2： | 1 |
| 4 | The GnRH antagonist cetrorelix reduces cyclophosphamide-induced ovarian follicular destruction in mice显示文摘 | Assad G Dor J | 2004 | Hum Reprod2004，19，6： | 1 |
| 5 | Pregnancy after transplantation of cryopreserved ovarian tissue in a patient with ovarian failure after chemotherapy显示文摘 | Meirow D Levron J Eldar-Geva T | 2005 | N Engl J Mod2005，353，3： | 1 |
| 6 | Evaluation and treatment of iatrogenic ureteral injuries during obstetric and gynecological operations for nonmalignant condiyions显示文摘 | Meirow D Moriel EZ Zilberman M | 1994 | J Coll Surg1994，178，2： | 1 |
| 7 | Monitoring the ova- ries after autotransplantation of cryopreserved ovarian tissue : en- docrine studies, in vitro fertilization cycles, and live birth 显示文摘 | Meirow D Levron J Eldar-Geva T | 2007 | Fertil Steril2007，87，2： | 1 |
| 8 | Monitoring the ovaries after autotransplantation of cryopreserved ovarian tissue:endocrine studies,in vitro fertilization cycles,and live birth显示文摘 | Meirow D Levron J Eldar-Geva T | | 0，，02： | 1 |
| 9 | Pregnancy after transplantation of eryopreserved ovarian tissue in a patient with ovarian failure after chemotherapy显示文摘 | Meirow D Levron J Eldar-Geva T | 2005 | N Engl J Med2005，353，3： | 1 |
| 10 | Subclinical depletion of primordial follicular reserve in mice treated with cyclophosphamide: clinical importance and proposed accurate investigative tool 显示文摘 | Meirow D Lewis H Nugant D | 1999 | Hum Repred1999，14，7： | 1 |
| 11 | A laparoscopic technique for obtaining ovarian cortical biopsy specimens for fertility conservation in patients with cancer显示文摘 | Meirow D Fasouliotis SJ Nugent D | 1999 | Fertil Steril1999，71，5： | 1 |
| 12 | Administration of cyclophosphamide at different stages of follicular maturation in mice: effects onreproductive performance and fetal malformations显示文摘 | Meirow D Epstein M Lewis H | 2001 | Hum Reprod2001，16，： | 1 |
| 13 | Toxicity of chemotherapy and radiation on female reproduction显示文摘 | Meirow D Biederman H Anderson RA | 2010 | Clin Obstet Gynecol2010，53，4： | 1 |
| 14 | Pregnancy af- ter transplantation of cryopreserved ovarian tissue in a pa- tient with ovarian failure after chemotherapy 显示文摘 | Meirow D Levron J Eldar-Geva T | 2005 | N Engl J Med2005，353，3： | 1 |
| 15 | Pregnancy after transplanta- tion of cryopreserved ovarian tissue in a patient with ovarian failure af- ter chemotherapy 显示文摘 | Meirow D Levron J Eldar-Geva T | 2005 | N Engl J Med2005，353，3： | 1 |
| 16 | Reproduction post-chemotherapy in young cancer patients显示文摘 | Meirow D | 2000 | Mol Cell Endocrinol2000，169，： | 1 |
| 17 | Subclinical depletion of primordial follicular reserve in mice treated with cyclophosphamide:clinical importance and proposed accurate investigative tool显示文摘 | Meirow D Lewis H Nugent D Epstein M | 1999 | Hum Reprod1999，14，7： | 1 |
| 18 | Pregnancy after transplantation of cryopreserved ovarian tissue in a patient with ovarian failure after chemotherapy显示文摘 | Meirow D Levron J Eldar-Geva T | 2005 | N Engl J Med2005，353，3： | 1 |
| 19 | Appraisal of chemotherapy effects on reproductive outcome according to animal studies and clinical data 显示文摘 | Meirow D Schiff E | 2005 | J Natl Cancer Inst Monogr2005，，34： | 1 |
| 20 | The effects of radiotherapy and chemotherapy on female reproduction 显示文摘 | Meirow D Nugent D | 2001 | Hum Reprod Update2001，7，6： | 1 |
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