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| 1 | Immunological mechanisms and therapeutic targets of fatty liver diseases显示文摘Alcoholic liver disease(ALD)and nonalcoholic fatty liver disease(NAFLD)are the two major types of chronic liver disease worldwide.Inflammatory processes play key roles in the pathogeneses of fatty liver diseases,and continuous inflammation promotes the progression of alcoholic steatohepatitis(ASH)and nonalcoholic steatohepatitis(NASH).Although both ALD and NAFLD are closely related to inflammation,their respective developmental mechanisms differ to some extent.Here,we review the roles of multiple immunological mechanisms and therapeutic targets related to the inflammation associated with fatty liver diseases and the differences in the progression of ASH and NASH.Multiple cell types in the liver,including macrophages,neutrophils,other immune cell types and hepatocytes,are involved in fatty liver disease inflammation.In addition,microRNAs(miRNAs),extracellular vesicles(EVs),and complement also contribute to the inflammatory process,as does intertissue crosstalk between the liver and the intestine,adipose tissue,and the nervous system.We point out that inflammation also plays important roles in promoting liver repair and controlling bacterial infections.Understanding the complex regulatory process of disrupted homeostasis during the development of fatty liver diseases may lead to the development of improved targeted therapeutic intervention strategies. | Hua Wang Wajahat Mehal Laura E.Nagy Yaron Rotman | 2021 | Cellular & Molecular Immunology2021，18，1： | 10 |
| 2 | Sterile Inflammation in the Liver显示文摘 | Paul Kubes Wajahat Z. Mehal | 2012 | Gastroenterology2012，，5： | 3 |
| 3 | Intraoperative epicardial electrophysiologic mapping and isolation of autonomic ganglionic plexi显示文摘 | Mehall JR Kohut RM Jr Schneeberger EW | 2007 | Ann Thorac Surg2007，83，2： | 1 |
| 4 | Porous materials show superhydrophobic to superamphiphilic switching 显示文摘 | Shirtcliffe N J Mehale G Newton M I | 2005 | Chem Commun2005，15，： | 1 |
| 5 | Magnetic resonance imaging and cervical spondylotic myelopathy显示文摘 | Mehalic T Pezzuti R Applebattm B | 1990 | Neurosurgery1990，26，2： | 1 |
| 6 | Imaeda A Cell death and fibrogenesis显示文摘 | Mehal W | | 0，，： | 1 |
| 7 | Transforaminal percutane- ous endoseopie diseeetomy in the treatment of far-lateral and foraminal lumbar disc herniations 显示文摘 | Lew SM Mehalic TF Fagone KL | 2001 | J Neurosurg2001，94，2： | 1 |
| 8 | Magnetic resonance imaging and cervical spondylotic myelopathy显示文摘 | Mehalic TF Pezzuti RT Applebaum BZ | 1990 | Neurosurgery1990，26，2： | 1 |
| 9 | Porous materials show superhydrophobic to superhydrophilic switching 显示文摘 | Shirtcliffe N J Mehale G Newton M I | 2005 | Chemical Communications2005，，25： | 1 |
| 10 | Transforaminal percutaneous endoscopic discectomy in the treatment of far-lateral and foram- inal lumbar disc herniations显示文摘 | Lew SM Mehalic TF Fagone KL | 2001 | J Neurosurg (Spine 2)2001，94，： | 1 |
| 11 | A survey of cytomegalovirus (CMV) DNA in primary sclerosing cholangitis liver tissues using a sensitive polymerase chain reaction (PCR) based assay 显示文摘 | Hattersley AT Chapman RW | 1992 | J Hepatol1992，15，3： | 1 |
| 12 | Transfominal percuta- neous endoscopic discectomy in the trealment of far - lateral and forminal lumber disc hemiations 显示文摘 | LEW S M MEHALIC T F FAGONE K L | 2001 | J Neurosurg2001，94，2： | 1 |
| 13 | HLA-DR4 is a marker for rapid disease progression in primary sclerosing cholangitis 显示文摘 | Lo YMD Wordsworth BP | 1994 | Gastroenterology1994，106，1： | 1 |
| 14 | HLA DR4 is a marker for rapid disease progression in primary sclerosing cholangitis 显示文摘 | Mehal WZ Lo YM Wordsworth BP | 1994 | Gastroenterology1994，106，1： | 1 |
| 15 | IL-18 augments perorin-dependent cytotoxicity of liver NK-T cells显示文摘 | Dao T Mehal W Z Crispe I N | 1998 | J Immunology1998，161，： | 1 |
| 16 | The novel TLR9 antagonist COV08-O064 protects from ischemia/repeffusion injury in non-steatotic and steatotic mice livers显示文摘 | Shaker M E Trawick B N Mehal W Z | 2016 | Biochem Pharmacol2016，112，： | 1 |
| 17 | Parkinson' s disease a- mong American Indians and Alaska natives: a nationwide prevalence study显示文摘 | Gordon PH Mehal JM Holman RC | 2012 | Mov Disor&2012，27，11： | 1 |
| 18 | The influence of prior abdominal operations on conversion and complication rates in laparoscopic colorectal surgery显示文摘 | Franko J O' Connell BG Mehall JR | 2006 | JSLS2006，10，2： | 1 |
| 19 | Enteral feeding tubes are a reservoir for nosocomial antibiotic-resistant pathogens 显示文摘 | Mehall JR Kite CA Oilliam CH | 2002 | J Pediatr Surg2002，37，11： | 1 |
| 20 | Pulsatile tinnitus associated with a laterally placed sigmoid sinus显示文摘 | MEHALL C J WILNER H I LAROUERE M J | 1995 | AJNR Am J Neuroradiol1995，16，4： | 1 |
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