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| 1 | Surgical treatment of a rare complication after endoscopic stent placement for anastomotic leakage after esophageal resection显示文摘The best approach to achieve cure in esophageal cancer is a combination of chemo-radiation and surgery. However, complications occur in half of patients. The current report, reports a rare but severe complication: Complete obstruction of the esophagus, induced by preoperative chemo-radiation therapy. Normally, strictures are treated by repeated dilatations, however, in case of complete obstruction, the perforation rate of standard blind anterograde wire access and dilation is severely increased. In order to minimize the risk of perforations, the rendezvous technique was introduced. This technique involves an anterograde approach in combination with a retrograde approach in order to open and dilatate the esophagus. While technical success rates between 83% and 100% have been reported in literature, data on clinical outcomes are scarcer. The limited amount of studies available claim that success was achieved in almost half of patients. The patient in our case currently has an oral diet without restrictions and rates his quality of life with a VAS-score ten out of ten. | Marjan Klinkert Mechteld C de Jong Meindert N Sosef Annick B van Nunen Henricus J Belgers | 2017 | World Journal of Surgical Procedures2017，7，1： | 1 |
| 2 | Rates and patterns of re- currence following curative intent surgery for colorectal liver metastasis: an international multi-institutional analysis of 1669 patients 显示文摘 | Mechteld C Carlo P Dario R | 2009 | Ann Surg2009，250，3： | 1 |
| 3 | Surgery versus intra arterial therapy for neuroendocrine liver metastasis : a multicenter interna- tional analysis 显示文摘 | Skye C Mechteld C Mark B | 2011 | Ann Surg Oncol2011，，18： | 1 |
| 4 | Evidence for an impatant role of the tonoplast in the mechanism of naturally selected zinctolerance in Silene vulgaris显示文摘 | VERKLEIJ J A C KOEVOETS P L M MECHTELD M A | 1998 | Journal of Plant Physiology1998，，153： | 1 |
| 5 | Liver-directed ther- apy for hepatic metastatic in patients undergoing pancreaticoduode- nectomy: a dual-center analysis 显示文摘 | Mechteld C Michael B Guido Sclabas etal | 2010 | Ann Surg2010，，252： | 1 |
| 6 | The impact of portal vein resection on outcomes for hilar cholangiocarci- noma显示文摘 | de long Mechteld C Marques Hugo Clary Bryan M | 2012 | Cancer2012，118，19： | 1 |
| 7 | Ophthalmic acid as a read-out for hepatic glutathione metabolism in humans显示文摘Background and Aim:Animal studies indicated that systemic ophthalmic acid(OPH)is a biomarker for hepatic glutathione(GSH)homeostasis,an important determinant of liver function.We aimed to clarify whether OPH levels can be used as a read-out for hepatic GSH homeostasis after paracetamol(APAP)challenges during pylorus-preserving pancreaticoduodenectomy(PPPD)or partial hepatectomy(PH).Methods:Nineteen patients undergoing PPPD(n=7,control group)or PH(n=12)were included.APAP(1000 mg)was administered intravenously before resection(first challenge),and six and twelve hours later,with sequential blood sampling during this period.Arterial,hepatic and portal venous blood samples and liver biopsies were taken on three occasions during the first APAP challenge.Plasma and hepatic OPH and GSH levels were quantified,and venous-arterial differences were calculated to study hepatic release.Results:Systemic GSH levels decreased during the course of the APAP challenge in both surgical groups,without notable change in OPH levels.Hepatic GSH and OPH content was not affected within^3 hours after administration of the first APAP dose in patients undergoing PPPD or PH.In this period,net release of OPH by the liver was observed only in patients undergoing PPPD.Conclusions:The drop in circulating GSH levels following APAP administrations,did not result in an increase in plasma OPH in both patients with an intact liver and in those undergoing liver resection.Hepatic content of GSH and OPH was not affected during the first APAP dose.It is uncertain whether hepatic GSH homeostasis was sufficiently challenged in the present study.Relevance for patients:In the present study,plasma OPH seemed not useful as a marker for GSH depletion because APAP administration during liver surgery did not lead to(immediate)GSH depletion or increased OPH levels.Based on stable levels of hepatic GSH,OPH and thiyl radicals during surgery,standard APAP administration seems to be safe in a postoperative care program with regards to GSH homeostasis in this specific population.However,no general statements can be made on the basis of the current experiment,since GSH homeostasis and susceptibility to xenobiotic toxicity are influenced by several metabolic and genetic factors. | Kim MC van Mierlo Simon AWG Dello Mechteld C de Jong Hans MH van Eijk Theo M de Kok Jacob J Briedé Frank G Schaap Steven WM Olde Damink Cornelius HC Dejong | 2017 | Journal of Clinical & Translational Research2017，3，4： | 0 |
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