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| 1 | High intensity focused ultrasound,liver disease and bridging therapy显示文摘High-intensity focused ultrasound(HIFU)is a noninvasive modality that uses an extracorporeal source of focused ultrasound energy.This technique was introduced by Lynn et al and is able to induce coagulative necrosis in selected tissues without damaging adjacent structures.Although HIFU has been studied for 50years,recent technological developments now allow its use for tumours of the liver,prostate and other sites.In liver disease,HIFU has been used to treat unresectable,advanced stages of hepatocellular carcinoma(HCC)and liver metastases.Hepatocellular carcinoma is a serious health problem worldwide and is endemic in some areas because of its association with hepatitis B and C viruses(in 20%of cases).Liver transplantation(LT)has become one of the best treatments available because it removes both the tumour and the underlying liver disease such as cirrhosis(which is present in approximately 80%of cases).The prerequisite for longterm transplant success depends on tumour load and strict selection criteria regarding the size and number of tumour nodules.The need to obtain the optimal benefit from the limited number of organs available has prompted strict selection criteria limited to only those patients with early HCC who have a better long-term outcome after LT.The so-called'bridging therapy'has the aim of controlling disease burden for patients who are on the organ transplant waiting list.Amongst various treatment options,transarterial chemoembolisation and radiofrequency ablation are the most popular treatment choices.Recently,Cheung et al demonstrated that HIFU ablation is a safe and effective method for the treatment of HCC patients with advanced cirrhosis as a bridging therapy and that it reduced the dropout rate from the liver transplant waiting list.In this commentary,we discuss the current value of HIFU in the treatment of liver disease,including its value as a bridging therapy,and examine the potential advantages of other therapeutic strategies. | Mearini Luigi | 2013 | World Journal of Gastroenterology2013，19，43： | 9 |
| 2 | Penile prosthesis implantation and couple's satisfaction显示文摘 | Porena M Mearini L Mearini E | | 0，，： | 1 |
| 3 | Assessment of bladder and urethral sphincter function before and after radical retrepubic pros tatectomy显示文摘 | Giannantoni A Mearini E Di-Stasi S M | 2004 | Urology2004，171，4： | 1 |
| 4 | Uterus preservation in surgical correction of urogenital prolapse显示文摘 | Costantini E Mearini L Bini V | 2005 | Eur Urol2005，48，： | 1 |
| 5 | The combination of urine DD3 (PCA3) mRNA and PSA mRNA as molecular markers of prostate cancer 显示文摘 | MEARINI E ANTOGNELLI C DELBUONO C | 2009 | Biomarkers2009，14，4： | 1 |
| 6 | Association of CYP17,GSTP1,and PON1 polymorphisms with the risk of prostate cancer显示文摘 | Antognelli G Mearini L Talesa VN | 2005 | Prostate2005，63，3： | 1 |
| 7 | Renal malignant soli- tary fibrous tumor with single lymph node involvement:report of unusual metastasis and review of the literature 显示文摘 | Mearini E Cochetti G Barillaro F | 2014 | Onco Tar- gets Ther2014，8，： | 1 |
| 8 | Penile prosthesis implantation and couple's satisfaction显示文摘 | Mearini L Mearini E | 2000 | Urol Int2000，63，： | 1 |
| 9 | Evaluation of prostate-specific antigen isoform p2PSA and its derivates,%p2PSA,prostate health index and prostate dimension-adjusted related index in the detection of prostate cancer at first biopsy:an exploratory,prospective study显示文摘 | Mearini L Ferri C Lazzeri M | 2014 | UrolInt2014，93，2： | 1 |
| 10 | Six-year follow-up of botulinum toxin A intradetrusorial injections in patients with refractory neurogenic detrusor overactivity: clinical and urodynamic results 显示文摘 | Giannantoni A Mearini E Del Zingaro M | 2009 | Eur Uro12009，55，3： | 1 |
| 11 | The combination of urine DD3 (PCA3) mRNA and PSAmRNA as molecular markers of prostate cancer 显示文摘 | Mearini E Antognelli C Del Buono C | 2009 | Biomakers2009，14，： | 1 |
| 12 | Botulinum toxin A for overactive bladder and detrusor muscle overactivity in patients with Parkinson's disease and multiple system atrophy 显示文摘 | Giannantoni A Rossi A Mearini E | 2009 | Urol2009，182，4： | 1 |
| 13 | Renal cell carcinoma: histological findings on surgical margins after nephmn sparing surgery 显示文摘 | Zuechi A Mearini L Mearini E | 2003 | J Urol2003，169，3： | 1 |
| 14 | Association of CYP17,GSTP1,and PON1 polymorphisms with the risk of prostate cancer显示文摘 | Antognelli C Mearini L Talesa VN | 2005 | Prostate2005，63，3： | 1 |
| 15 | Botulinum toxin A for overactive bladder and detrusor muscle overactivity in pa- tients with Parkinson' s disease and multiple system atro- phy显示文摘 | Giannantoni A Rossi A Mearini E | 2009 | J Uro12009，182，4： | 1 |
| 16 | Botulinum toxin A for overactive bladder and detrusor muscle overactivity in patients with Parkinson's disease and multiple system atrophy显示文摘 | Giannantoni A Rossi A Mearini E | | 0，，4： | 1 |
| 17 | Uterus preservation in surgical correction of urogenital prolapse显示文摘 | Costantini E Mearini L Bini V | 2005 | Eur Urol2005，48，4： | 1 |
| 18 | Adrenal onco-cytic neoplasm : a systematic review显示文摘 | Mearini L Del Sordo R Costantini E | 2013 | Urol Int2013，91，2： | 1 |
| 19 | Treatment of varicocele:randomized prospective study on open surgery versus tauber antegrade sclerotherapy 显示文摘 | Alessandro Zucchi Luigi Mearini Ettore Mearin | 2005 | Journal of Andrology2005，26，3： | 1 |
| 20 | Renal cell carcinoma:histological findings on surgical margins after nephron sparing surgery显示文摘 | Zucchi A Mearini L Mearini E | 2003 | J Urol2003，169，3： | 1 |
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