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| 1 | Fatty liver disease,an emerging etiology of hepatocellular carcinoma in Argentina显示文摘AIM To investigate any changing trends in the etiologies of hepatocellular carcinoma(HCC) in Argentina during the last years. METHODS A longitudinal cohort study was conducted by 14 regional hospitals starting in 2009 through 2016. All adult patients with newly diagnosed HCC either with pathology or imaging criteria were included. Patients were classified as presenting non-alcoholic fatty liver disease(NAFLD) either by histology or clinically, provided that all other etiologies of liver disease were ruled out, fatty liver was present on abdominal ultrasound and alcohol consumption was excluded. Complete follow-up was assessed in all included subjects since the date of HCC diagnosis until death or last medical visit.RESULTS A total of 708 consecutive adults with HCC were included. Six out of 14 hospitals were liver transplant centers(n = 484). The prevalence of diabetes mellitus was 27.7%. Overall, HCV was the main cause of liver disease related with HCC(37%) including cirrhotic and non-cirrhotic patients, followed by alcoholic liver disease 20.8%, NAFLD 11.4%, cryptogenic 9.6%, HBV 5.4% infection, cholestatic disease and autoimmune hepatitis 2.2%, and other causes 9.9%. A 6-fold increase in the percentage corresponding to NAFLDHCC was detected when the starting year, i.e., 2009 was compared to the last one, i.e., 2015(4.3% vs 25.6%; P < 0.0001). Accordingly, a higher prevalence of diabetes mellitus was present in NAFLD-HCC group 61.7% when compared to other than NAFLD-HCC 23.3%(P < 0.0001). Lower median AFP values at HCC diagnosis were observed between NAFLD-HCC and non-NAFLD groups(6.6 ng/m L vs 26 ng/m L; P = 0.02). Neither NAFLD nor other HCC etiologies were associated with higher mortality.CONCLUSION The growing incidence of NAFLD-HCC documented in the United States and Europe is also observed in Argentina, a confirmation with important Public Health implications. | Federico Pinero Josefina Pages Sebastián Marciano Nora Fernández Jorge Silva Margarita Anders Alina Zerega Ezequiel Ridruejo Beatriz Ameigeiras Claudia D’Amico Luis Gaite Carla Bermúdez Manuel Cobos Carlos Rosales Gustavo Romero Lucas McCormack Virginia Reggiardo Luis Colombato Adrián Gadano Marcelo Silva | 2018 | World Journal of Hepatology2018，10，1： | 4 |
| 2 | Noninvasive posi- tive-pressure ventilation for postextubation respiratory distress: a randomized controlled trial显示文摘 | Keenan S P Powers C McCormack D G et aI | 2002 | JAMA2002，287，24： | 1 |
| 3 | Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators显示文摘 | Burke JG Watson RW McCormack D | 2002 | J Bone Joint Surg Br2002，84，2： | 1 |
| 4 | Spontaneous production of monocyte chemoattractant protein-1 and interleukin-8 by the human lumbar intervertebral disc 显示文摘 | Burke JG Watson RW McCormack D | 2002 | Spine2002，27，： | 1 |
| 5 | Measuring patient centered communication in cancer care: a literature review and the development of a systematic approach 显示文摘 | McCormack L A Treiman K Rupert D | 2011 | Soc Sci Med2011，72，10： | 1 |
| 6 | Calculations of electric double-layer force and interaction free-energy between dissimilar surfaces 显示文摘 | McCormack D Carnie S L Chan D Y C | 1995 | J Colloid lnterf Sci1995，169，1： | 1 |
| 7 | The genital mycoplasmas (first of two parts) 显示文摘 | Taylor-Robinson D Mccormack WM | 1980 | N Engl J Med1980，302，18： | 1 |
| 8 | Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators显示文摘 | Burke JG Watson RW McCormack D | 2002 | J Bone Joint Surg(Br)2002，84，2： | 1 |
| 9 | Interver- tebral discs which cause low back pain secrete high lev- els of proinflammatory mediators 显示文摘 | Burke JG Watson RWG McCormack D | 2002 | J Bone Joint Surg (Br)2002，84，2： | 1 |
| 10 | Intervertebral discs which cause low backpain secrete high levels of proinflammatory me- diators 显示文摘 | Burke JG Watson RW McCormack D | 2002 | J Bone Joint Surg Br2002，84，： | 1 |
| 11 | Pterostilbene and cancer:current review显示文摘 | McCormack D McFadden D | 2012 | Journal of Surgical Research2012，173，2： | 1 |
| 12 | Improved high-temperature stability and sun-light-driven photocatalytic activity of sulfur-doped anatase TiO2 显示文摘 | Periyat P Pillai S C McCormack D E | 2008 | J Phys Chem C2008，112，： | 1 |
| 13 | Intervertebral discs which cause low back pain secrete high levels of proinflammato- ry mediators显示文摘 | Burke J G Watson R W McCormack D | 2002 | J Bone Joint Surg Br2002，84，2： | 1 |
| 14 | Tuberous scle-rosis complex: neurological,renal and pulmonary mani-festations显示文摘 | Franz D N Bissler J J Mccormack F X | 2010 | Neuropediatrics2010，41，5： | 1 |
| 15 | Surfactant protein D binds to Mycobacterium tuberculosis bacilli and lipoarabinomannan via carbohydrate-lectin interactions re- sulting in reduced显示文摘 | Ferguson J S Voelker D R McCormack F X | 1999 | J Immunol1999，163，1： | 1 |
| 16 | Pterostilbene and cancer: current review显示文摘 | McCormack D McFadden D | 2012 | J Surg Res2012，173，2： | 1 |
| 17 | Neural computing in geophysics显示文摘 | McCormack M D | 1991 | The Leading Edge1991，10，1： | 1 |
| 18 | Peer Nomination: A Tool for Identifying Medical Student Exemplars in Clinical Competence and Caring, Evaluated at Three Medical Schools 显示文摘 | McCormack W T Lazarus C Stern D etal | 2007 | Academic Medicine2007，82，11： | 1 |
| 19 | The effect of mechanical vibration on the breakup of a cylindrical water jet in air显示文摘 | Creane L Birch S McCormack P D | 1978 | Brit J Appl Phys1978，15，： | 1 |
| 20 | A synthetic bone implant macroscopically identical to cancellous bone 显示文摘 | Tancred D C McCormack B A O Carr A J | 1998 | Biomaterials1998，19，： | 1 |
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