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| 1 | HCV-specific cytokine induction in monocytes of patients with different outcomes of hepatitis C显示文摘AIM:Cytokine release by macrophages critically determines the type of immune response to an antigen Therefore.we studied hepatitis C virus (HCV0-Specific induction of interleukins-1β,-10,-12(IL-1β,il-10,IL-12),and tumor necrosis factor-α(TNF-α) in monocytes.METHODS:Intracellular cytokine expression was studied by flow cytometry in 23 patients with chronic hepatitis C,14 anti-HCV seropositives without viremia and 11 controls after stimulation of peripheral blood mononuclear cells with recombinant core,NS3,NS4 NS5a and NS5b proteins .RESULTS:Patients with HCV viremia revealed greater spontaneous exprssion of IL-1β,TNF-α,and IL-10,Furthermore,greater than twofold higher IL-10 epression was induced by the HCV antigens in chronic hepatitis C than in the other two groups (P<0.05) In contrast,neither IL-12 noir TNF-α was induced preferentially.CONCLUSION:In chonic hepatitis C antigen-specific cytokine induction in monocytes is apparently shifted towards predominant IL-10 induction-not counterbalanced by antiviral type 1 cytokines,This may contribute to persistent viral replication. | Rainer P.Woitas Uwe Petersen Dirk Moshage Hans H.Brackmann Bertfried Matz Tilman Sauerbruch Ulrich Spengler | 2002 | World Journal of Gastroenterology2002，8，3： | 15 |
| 2 | Ischemic preconditioning-induced hyperperfusion correlates with hepatoprotection after liver resection显示文摘AIM:To characterize the impact of the Pringle ma-neuver (PM) and ischemic preconditioning (IP) on total blood supply to the liver following hepatectomies. METHODS: Sixty one consecutive patients who un-derwent hepatic resection under in flow occlusion were randomized either to receive PM alone (n = 31) or IP (10 min of ischemia followed by 10 min of reperfusion) prior to PM (n = 30). Quantification of liver perfusion was measured by Doppler probes at the hepatic artery and portal vein at various time points after reperfusion of remnant livers. RESULTS: Occlusion times of 33 ± 12 min (mean ± SD) and 34 ± 14 min and the extent of resected liver tissue (2.7 segments) were similar in both groups. In controls (PM), on reperfusion of liver remnants for 15 min, portal perfusion markedly decreased by 29% while there was a slight increase of 8% in the arterial blood flow. In contrast, following IP + PM the portal vein flow remained unchanged during reperfusion and a significantly increased arterial blood flow (+56% vs baseline) was observed. In accordance with a better postischemic blood supply of the liver, hepatocellular injury, as measured by alanine aminotransferase (ALT) levels on day 1 was considerably lower in group B compared to group A (247 ± 210 U/I vs 550 ± 650 U/I, P < 0.05). Additionally, ALT levels were significantly correlated to the hepatic artery in flow.CONCLUSION: IP prevents postischemic flow reduction of the portal vein and simultaneously increases arterial perfusion, suggesting that improved hepatic macrocirculation is a protective mechanism following hepatectomy. | Oleg Heizmann Georgios Meimarakis Andreas Volk Daniel Matz Daniel Oertli Rolf J Schauer | 2010 | World Journal of Gastroenterology2010，16，15： | 12 |
| 3 | Algorithms for evaluating the appropriateness of blood transfusion 显示文摘 | COFFIN C MATZ K RICH E | 1989 | Transfusion1989，29，： | 1 |
| 4 | Cervical surgical techniques for the treatment of cervical spondylotic myelopathy显示文摘 | Mummaneni PV Kaiser MG Matz PG | 2009 | J Neurosurg Spine2009，11，2： | 1 |
| 5 | Impact of violaceinproducing bacteria on survival and feeding of bacterivorous nanoflagellates显示文摘 | Matz C Deines P Boenigk J | 2004 | Appl Environ Microbiol2004，70，： | 1 |
| 6 | Fluorescent proteins from nonbioluminescent Anthozoa species显示文摘 | Matz M V Fradkov A F Labas Y A | 1999 | Nat Biotechnol1999，17，10： | 1 |
| 7 | Free radical pathways in CNS injury显示文摘 | LEWEN A MATZ P CHAN P H | 2000 | J Neurotrauma2000，17，10： | 1 |
| 8 | Ordered differential dis play: a simple method for systematic comparison of gene ex pression profiles显示文摘 | Matz M Usman N Shagin D | 1997 | Nucleic Acids Research1997，25，12： | 1 |
| 9 | Omalizumab provides long-term control in patients with moderate-to-severe allergic asthma显示文摘 | Buhl R Soler M Matz J | 2002 | Eur Respir J2002，20，1： | 1 |
| 10 | Disorders of glucose metabolism in acute Stroke patients: an underrcognized problem显示文摘 | Matz K Keresztes K Tatschl C | 2006 | Diabetes Care2006，29，4： | 1 |
| 11 | Microstructure and oxidation kinetics of intermetallic TiAl after Si-and Mo-ion implantation显示文摘 | HORNAUER U RICHTER E MATZ W REUTHER H MUCKLICH A WIESER E MOLLER W SCHUMACHER G SCHUTZE M | 2000 | Surface and Coatings Technology2000，，： | 1 |
| 12 | Fluorescent pro- teins from nonbioluminescent Anthozoa species 显示文摘 | MATZ M V FRADKOV AF LABAS Y A | 1999 | Nat Bio- technol1999，17，： | 1 |
| 13 | Subarachnoid hemolysate produces DNA fragmentation in a pattern similar to apoptosis in mouse brain显示文摘 | Matz PG Fujimura M Chan PH | 2000 | Brain Res2000，858，： | 1 |
| 14 | Dynamics of Particulate Formation in the Electron Beam Dry Serubing Process 显示文摘 | Matzing H | 1988 | J Aerosol Sci1988，19，7： | 1 |
| 15 | A likelihood ratio rest test for species membership based on DNA sequence data 显示文摘 | Matz MV Nielsen R 2005 | 1969 | Philosophical Transactions of the Royal Society of London-Series B : Biological Sciettces1969，360，： | 1 |
| 16 | Impact of violaceinproducing bacteria on survival and feeding of bacterivorous nanoflagellates显示文摘 | Matz C Deines P Boenigk J | | 0，，03： | 1 |
| 17 | Profiling gene expression responses of coral larvae (Acropora millepora) to elevated tempera- ture and settlement inducers using a novel RNA-Seq procedure 显示文摘 | Meyer E Aglyamova G Matz M | 2011 | Molecular Ecology2011，20，17： | 1 |
| 18 | Laminectomy and fusion for the treatment of cervical degenerative myelopathy 显示文摘 | Anderson P A Matz P G Groff M W | 2009 | J Neurosurg Spine2009，11，2： | 1 |
| 19 | Free radical pathways in CNS injury 显示文摘 | Lewen A Matz P Chan PH | 2000 | J Neurotrauma2000，17，： | 1 |
| 20 | Free radical pathways in CNS injury显示文摘 | Lewen A Matz P Chan P H | 2000 | JNeurotrauma2000，17，10： | 1 |
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