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1篇 您的检索式：作者名="Matthew PGoetz"

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		题名	作者	年代	出处	被引量
	1	Regulation of sister chromatid cohesion by nuclear PD-L1显示文摘Programmed death ligand-1(PD-L1 or B7-H1)is well known for its role in immune checkpoint regulation,but its function inside the tumor cells has rarely been explored.Here we report that nuclear PD-L1 is important for cancer cell sister chromatid cohesion.We found that depletion of PD-L1 suppresses cancer cell proliferation,colony formation in vitro,and tumor growth in vivo in immune-deficient NSG mice independent of its role in immune checkpoint.Specifically,PD-L1 functions as a subunit of the cohesin complex,and its deficiency leads to formation of multinucleated cells and causes a defect in sister chromatid cohesion.Mechanistically,PD-L1 compensates for the loss of Sororin,whose expression is suppressed in cancer cells overexpressing PD-L1.PD-L1 competes with Wing Apart-Like(WAPL)for binding to PDS5B,and secures proper sister chromatid cohesion and segregation.Our findings suggest an important role for nuclear PD-L1 in cancer cells independent of its function in immune checkpoint.	Jia Yu Bo Qin Ann MMoyer Somaira Nowsheen Xinyi Tu Haidong Dong Judy CBoughey Matthew PGoetz Richard Weinshilboum Zhenkun Lou Liewei Wang	2020	Cell Research2020，30，7：	3

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