2篇
您的检索式：作者名="Matteo Lambertini"
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| 1 | Biology, staging, and treatment of breast cancer during pregnancy: reassessing the evidences显示文摘Breast cancer is one of the most frequently diagnosed malignancies during pregnancy. Here, we review the management of women with breast cancer during pregnancy(BCP), focusing on biology, diagnosis and staging, local and systemic treatments, obstetric care and long-term follow-up of children with prenatal exposure to anticancer treatments. | Fedro Alessandro Peccatori Matteo Lambertini Giovanna Scarfone Lino Del Pup Giovanni Codacci-Pisanelli | 2018 | Cancer Biology & Medicine2018，15，1： | 9 |
| 2 | Targeting triple-negative breast cancer:A clinical perspective显示文摘Triple-negative breast cancer(TNBC)is a disease with often an aggressive course and a poor prognosis compared to other subtypes of breast cancer.TNBC accounts for approximately 10%–15%of all diagnosed breast cancer cases and represents a high unmet need in the field.Up to just a few years ago,chemotherapy was the only systemic treatment option for this subtype(1).To date,TNBC is considered a heterogeneous disease.One of the existing classifications is based on the analysis of mRNA expression in 587 TNBC cases,in which Lehman et al.proposed six subtypes of TNBC as follows:two basal-like(BL1 and BL2)subtypes,a mesenchymal(M)subtype,a mesenchymal stem-like(MSL)subtype,an immunomodulatory(IM)subtype,and a luminal androgen receptor(LAR)subtype(2).Later studies have demonstrated that the IM and MSL subtypes do not correlate with independent subtypes but reflect background expression by dense infiltration of tumor-infiltrating lymphocytes(TILs)or stromal cells.According to this finding,the classification of TNBC has been revised into the following four subtypes:basal 1,basal 2,LAR,and mesenchymal subtypes(3).Over the last years,several new strategies have been investigated for the treatment of patients with TNBC.Among them,immunotherapy,antibody drug conjugates,new chemotherapy agents,and targeted therapy have been and are currently being developed.The present article aims to provide an updated overview on the different treatment options that are now available or are still under investigation for patients with TNBC. | LAZAR S.POPOVIC GORANA MATOVINA-BRKO MAJA POPOVIC KEVIN PUNIE ANA CVETANOVIC MATTEO LAMBERTINI | 2023 | Oncology Research2023，31，3： | 0 |
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