|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Ten years of sorafenib in hepatocellular carcinoma: Are there any predictive and/or prognostic markers?显示文摘Sorafenib has been considered the standard of care for patients with advanced unresectable hepatocellular carcinoma(HCC) since 2007 and numerous studieshave investigated the role of markers involved in the angiogenesis process at both the expression and genetic level and clinical aspect. What results have ten years of research produced? Several clinical and biological markers are associated with prognosis. The most interesting clinical parameters are adverse events, Barcelona Clinic Liver Cancer stage, and macroscopic vascular invasion, while several single nucleotide polymorphisms and plasma angiopoietin-2 levels represent the most promising biological biomarkers. A recent pooled analysis of two phase III randomized trials showed that the neutrophil-to-lymphocyte ratio, etiology and extra-hepatic spread are predictive factors of response to sorafenib, but did not identify any predictive biological markers. After 10 years of research into sorafenib there are still no validated prognostic or predictive factors of response to the drug in HCC. The aim of the present review was to summarize 10 years of research into sorafenib, looking in particular at the potential of associated clinical and biological markers to predict its efficacy in patients with advanced HCC. | Giorgia Marisi Alessandro Cucchetti Paola Ulivi Matteo Canale Giuseppe Cabibbo Leonardo Solaini Francesco G Foschi Serena De Matteis Giorgio Ercolani Martina Valgiusti Giovanni L Frassineti Mario Scartozzi Andrea Casadei Gardini | 2018 | World Journal of Gastroenterology2018，24，36： | 14 |
| 2 | Application of Trichoderma harzianum (T22) and Trichoderma atroviride (P1) as plant growth promoters, and their compatibility with copper oxychloride显示文摘Trichoderma strains are used in agriculture because they provide to the plants the following benefits: i) are rhizosphere competence and establish stable rhizosphere microbial communities; ii) control plant disease caused by pathogenic and competitive microflora, by using a variety of mechanisms; iii) improve vegetative growth, root development and yield; iv) make nutrients more available to the plant. In this work we have investigated the ability of T. harzianum T22 and T. atroviride P1 to improve plant growth of locally important horticultural crops: lettuce, tomatoes and peppers and to prevent disease in the greenhouse and field. The effect of the Trichoderma treatment was evaluated by determining the weight of fresh and dry roots and above ground plant biomass, measuring plants height, counting the number of emerged leaves (lettuce, tomatoes and peppers) and quantifying production (tomatoes and peppers). No disease symptoms were found during production, although Fusarium sp. strains pathogenic to tomato were detected in the soil. Compounds containing copper oxychloride are frequently used for fungal disease control in agriculture. In order to investigate the compatibility of T. harzianum T22 and T. atroviride P1 with copper oxychloride applications, the effect on mycelia growth was monitored in both liquid and solid medium. In general, the tests indicated a high level of tolerance of the Trichoderma strains to concentrations of copper oxychloride varying from 0.1 to 5 mmol/L. | Francesco Vinale Gaetano D'Ambrosio Khalid Abadi Felice Scala Roberta Marra David Turrà Sheridan L Woo Matteo Lorito | 2004 | 浙江大学学报(农业与生命科学版)2004，30，4： | 7 |
| 3 | A systematic review and meta-analysis of clinical trials implementing aromatase inhibitors to treat male infertility显示文摘Aromatase activity has commonly been associated with male infertility characterized by testicular dysfunction with low serum testosterone and/or testosterone to estradiol ratio.In this subset of patients,and particularly in those with hypogonadism,elevated levels of circulating estradiol may establish a negative feedback on the hypothalamic–pituitary–testicular axis by suppressing follicle-stimulating hormone(FSH)and luteinizing hormone(LH)production and impaired spermatogenesis.Hormonal manipulation via different agents such as selective estrogen modulators or aromatase inhibitors to increase endogenous testosterone production and improve spermatogenesis in the setting of infertility is an off-label option for treatment.We carried out a systematic review and meta-analysis of the literature of the past 30 years in order to evaluate the benefits of the use of aromatase inhibitors in the medical management of infertile/hypoandrogenic males.Overall,eight original articles were included and critically evaluated.Either steroidal(Testolactone)or nonsteroidal(Anastrozole and Letrozole)aromatase inhibitors were found to statistically improve all the evaluated hormonal and seminal outcomes with a safe tolerability profile.While the evidence is promising,future prospective randomized placebo-controlled multicenter trials are necessary to better define the efficacy of these medications. | Francesco Del Giudice Gian Maria Busetto Ettore De Berardinis Isabella Sperduti Matteo Ferro Martina Maggi Martin S Gross Alessandro Sciarra Michael L Eisenberg | 2020 | Asian Journal of Andrology2020，22，4： | 5 |
| 4 | Transient micro-elastography:A novel non-invasive approach to measure liver stiffness in mice显示文摘AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below the xiphoid cartilage,with a mean LS of 4.4 ± 1.3 kPa,a mean success rate of 88%,and an excellent intra-observer agreement(0.98).Treatment with CCl4 over seven weeks drastically increased LS as compared to controls(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis stage was highly correlated with LS(Spearman coefficient = 0.88,P < 0.01).In the amyloidosis model,much higher LS values were obtained,reaching maximum values of > 150 kPa.LS significantly correlated with the amyloidosis index(0.93,P < 0.0001) and the plasma concentration of mutant hapoA-□(0.62,P < 0.005).CONCLUSION:Here,we have established the first non-invasive approach to measure LS in mice,and have successfully validated it in two murine models of high LS. | Cécile Bastard Matteo R Bosisio Michèle Chabert Athina D Kalopissis Meriem Mahrouf-Yorgov Hélène Gilgenkrantz Sebastian Mueller Laurent Sandrin | 2011 | World Journal of Gastroenterology2011，17，8： | 4 |
| 5 | Evidence to suggest adoption of water exchange deservesbroader consideration:Its pain alleviating impact occurs in90%of investigators显示文摘AIM: To determine variations in colonoscopy real-time insertion pain among investigators using three different insertion techniques.METHODS: From March 2013 through June 2014, 18-85-year-old diagnostic and 50-70-year-old screening patients were enrolled at each center to on-demand sedation colonoscopy with water exchange(WE), water immersion(WI) and insufflation with air or CO2 for insertion and withdrawal [air or carbon dioxide(AICD)]. Data were aggregated for analysis. Primary outcome: Variations in real-time maximum insertion pain(0 = none, 1-2 = discomfort, 10 = worst).RESULTS: One thousand and ninety-one cases analyzed: WE(n = 371); WI(n = 338); AICD(n = 382). Demographics and indications were comparable. The WE group had the lowest real-time maximum insertion pain score, mean(95%CI): WE 2.8(2.6-3.0), WI 3.8(3.5-4.1) and AICD 4.4(4.1-4.7), P < 0.0005. Ninety percent of the colonoscopists were able to use water exchange to significantly decrease maximum insertion pain scores. One investigator had high insertion pain in all groups, nonetheless WE achieved the lowest real-time maximum insertion pain score. WE had the highest proportions of patients with painless unsedated colonoscopy(vs WI, P = 0.013; vs AICD, P < 0.0005); unsedated colonoscopy with only minor discomfort(vs AICD, P < 0.0005), and completion without sedation(vs AICD, P < 0.0005).CONCLUSION: Aggregate data confirm superiority of WE in lowering colonoscopy real-time maximum insertion pain and need for sedation. Ninety percent of investigators were able to use water exchange to significantly decrease maximum insertion pain scores. Our results suggest that the technique deserves consideration in a broader scale. | Sergio Cadoni Mauro Liggi Premysl Falt Stefano Sanna Mariangela Argiolas Viviana Fanari Paolo Gallittu Donatella Mura Maria L Porcedda Vit Smajstrla Matteo Erriu Felix W Leung | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，2： | 2 |
| 6 | An increased vulnerability to stress is associated with a poor outcome of in vitro fertilization-embryo transfer treatment显示文摘 | Facchinetti F Volpe A Matteo M L | 1997 | Fertil Steril1997，67，2： | 1 |
| 7 | Surgical therapy formetastatic disease to the liver显示文摘 | Bentrem D J de Matteo R P Blumgart L H | 2005 | Ann Rev Med2005，56，： | 1 |
| 8 | Validation of an antbsphingosine-l-phos- phate antibody as a potential therapeutic in reducing growth, invasion,and angiogenesis in multiple tumor lineages显示文摘 | Visentin B Vekich J A Sibbald B J Cavalli A L Moreno K M Matteo R G | 2006 | Canc- er Cell2006，9，： | 1 |
| 9 | Intratesticular feedback mechanisms in the regulation of steroid profiles in the frog,Rana esculenta显示文摘 | Fasano S Minucci S Di Matteo L | 1989 | Gen Comp Endocrinol1989，75，3： | 1 |
| 10 | The orbital glands of the terrapin Pseudemys scripta in response to osmotic stress:a light and electron microscope study显示文摘 | Baccari G C Minucci S Di Matteo L | 1993 | J Anat1993，183，1： | 1 |
| 11 | Polygalacturonnse inhibiting proteins:players in plant innate immunity显示文摘 | Federici L Di Matteo A Fernandez-Recio J | | 0，，02： | 1 |
| 12 | Combined medicalhysteroscopic conservative treatment of a viable cervical pregnancy:A case report 显示文摘 | Matteo M Nappi L Rosenberg R | 2006 | Journal of Minimally Invasive Gynecology2006，13，4： | 1 |
| 13 | Under- hood Cooling Simulation for Development of New Vehicles显示文摘 | Fortunato F Damiano F Matteo L D | 2005 | SAE Paper2005，，： | 1 |
| 14 | Immunological changes and stress are associated with different implantation rates in patients undergoing in vitro fertilizationembryo transfer显示文摘 | GALLINELLI A RONCAGLIA R MATTEO M L | 2001 | Fertil Steril2001，76，1： | 1 |
| 15 | Two hundred gastrointestinal stromal tumor: recurrence patterns and prognostic factors for survival显示文摘 | De Matteo RP Lewis jj L Leung D | 2000 | Am Surg2000，231，： | 1 |
| 16 | Myeloma bone disease : Pathogenetic mechanisms and clinical assessment 显示文摘 | Silvestris F Lombari L De Matteo M | 2007 | Leukemia Research2007，31，12： | 1 |
| 17 | Evidence on the determinants of Canadian provincial government health expenditures:1965-1991显示文摘 | Matteo L D Matteo R D | | 0，，02： | 1 |
| 18 | The crystal structure of PGIP (polygalacturonase-inhibiting protein), a leucine-rich repeat protein involved in plant defense 显示文摘 | Di Matteo A Federici L Mattei B Salvi G Johnson K A Savino C DeLorenzo G Tsernoglou D Cervone F | 2003 | Proc Natl Acad Sci2003，100，10： | 1 |
| 19 | Detachment folding in the central and eastern Zagros fold-belt (Iran):salt mobility,multiple detach-ments and late basement control显示文摘 | Shahram S Matteo M Dominique F L | | 0，，9： | 1 |
| 20 | Myeloma bone disease:pathogenetic mechanisms and clinical assessment显示文摘 | Silvestris F Lombardi L De Matteo M | 2007 | Leuk Res2007，31，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员