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| 1 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 2 | Clinical characteristics and in-hospital outcome of patients with acute coronary syndromes and systemic lupus erythematosus显示文摘 | de Matos Soeiro A de Almeida Soeiro MC de Oliveira MT Jr el al | 2014 | Rev Port Cardiol2014，33，11： | 1 |
| 3 | The electrochemical oxidation of xylitol on Pt(Ⅲ) in acid medium显示文摘 | MATOS J P F PROENCA L LOPES M I S el al | 2004 | Journal of Electroanalytical Chemistry2004，571，1： | 1 |
| 4 | Pseudogenization of the MCP-2/CCL8 chemokine gene in European rabbit(genus Oryctolagus),but not in species of Cottontail rabbit(Sylvilagus)and Hare(Lepus)显示文摘 | van der Loo W Afonso S de Matos AL | 2012 | Bmc Genet2012，13，： | 1 |
| 5 | Morphological and yield components and isozyme characterization of Portuguese rye populations显示文摘 | CARNIDE V PINTO-CARNIDE O MATOS M ct al | 1997 | Appl Genet1997，，： | 1 |
| 6 | Evaluation of delayed neuronal and axonal damage secondary to moderate and severe traumatic brain injury using quantitative MR Imaging techniques 显示文摘 | Mamere AE Saraiva LA Matos AL | 2009 | AJNR Am J Neuroradiol2009，30，5： | 1 |
| 7 | Evaluation of delayed neuronal and axonal damage secondary to moderate and severe traumatic brain injury using quantitative MR imaging techniques 显示文摘 | Mamere AE Saraiva LA Matos AL | 2009 | AJNR Am J Neuroradiol2009，30，5： | 1 |
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