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		题名	作者	年代	出处	被引量
	1	The PIWI protein Aubergine recruits eIF3 to activate translation in the germ plasm显示文摘Piwi-interacting RNAs(piRNAs)and PIWI proteins are essential in germ cells to repress transposons and regulate mRNAs.In Drosophila,piRNAs bound to the PIWI protein Aubergine(Aub)are transferred maternally to the embryo and regulate maternal mRNA stability through two opposite roles.They target mRNAs by incomplete base pairing,leading to their destabilization in the soma and stabilization in the germ plasm.Here,we report a function of Aub in translation.Aub is required for translational activation of nanos mRNA,a key determinant of the germ plasm.Aub physically interacts with the poly(A)-binding protein(PABP)and the translation initiation factor elF3.Polysome gradient profiling reveals the role of Aub at the initiation step of translation.In the germ plasm,PABP and elF3d assemble in foci that surround Aub-containing germ granules,and Aub acts with elF3d to promote nanos translation.These results identify translational activation as a new mode of mRNA regulation by Aub,highlighting the versatility of PIWI proteins in mRNA regulation.	Anne Ramat Maria-Rosa Garcia-Silva Camille Jahan Rima Nait-Saidi Jeremy Dufourt Celine Garret Aymeric Chartier Julie Cremaschi Vipul Patel Mathilde Decourcelle Amandine Bastide Francois Juge Martine Simonelig	2020	Cell Research2020，30，5：	1

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