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| 1 | Giardia lamblia infection in patients with irritable bowel syndrome and dyspepsia:A prospective study显示文摘瞄准:评估兰伯氏贾第虫的流行(G。兰氏鞭毛虫属) 在有急躁的肠症候群(IBS ) 和消化不良并且到的病人的感染证实哪个是最精确的测试在这个背景诊断感染。方法:连续地由于 IBS 或消化不良的症状在 2002 年 1 月和 2003 年 12 月之间第一次出席了门诊病人肠胃病学诊所的 137 个病人被招募。所有病人经历了临床的评估,第一步的 haematology 和化学测试,为乳糜泻的血清学试金, lactose-H (2 ) 呼吸测试,腹的 ultrasonography,和 esophagogastroduodenoscopy。Helicobacter pylori 地位被评估。在有比 45 年旧的 IBS 的症状的病人,结肠镜检查也被执行。在所有病人,十二指肠的活体检视和凳子样品为 G 的 trophozoites 和包囊被检验。由几个方法的兰氏鞭毛虫属。结果:G。兰氏鞭毛虫属在 9 个病人被识别。下列诊断也被做:IBS (100/137, 73%) ,机能性消化不良(62/137, 45%) ,器官的消化不良(33/137, 24%) ,并且乳糖不耐(75/137, 55%) 。一个重要协会在贾第虫病和 H pylori 感染之间被发现(c2=6.632, OR=12.4, CI=1.5-68.1 ) 。没有症状,可靠地允许贾第虫病的识别。当十二指肠的活体检视的组织学的检查显示了低敏感时,在十二指肠的活体检视和凳子样品考试的寄生虫的直接搜索在所有情况中给了一致结果(例如, 22.2%) 。结论:在这个连续系列, G 的诊断。兰氏鞭毛虫属感染与 IBS 和消化不良说明了 6.5% 病人。如果凳子样品检查被执行,为贾第虫病的诊断的十二指肠的活体检视可能是不必要的。 | Barbara Grazioli Giovanni Matera Costanza Laratta Giuseppina Schipani Giovanni Guarnieri Ester Spiniello Maria Imeneo Andrea Amorosi Alfredo Focà Francesco Luzza | 2006 | World Journal of Gastroenterology2006，12，12： | 4 |
| 2 | DNA end binding activity and Ku70/80 heterodimer expression in human colorectal tumor显示文摘AIM: To determine the DNA binding activity and protein levels of the Ku70/80 heterodimer, the functional mediator of the NHEJ activity, in human colorectal carcinogenesis.METHODS: The Ku70/80 DNA-binding activity was determined by electrophoretic mobility shift assays in 20 colon adenoma and 15 colorectal cancer samples as well as matched normal colonic tissues. Nuclear and cytoplasmic protein expression was determined by immunohistochemistry and Western blot analysis.RESULTS: A statistically significant difference was found in both adenomas and carcinomas as compared to matched normal colonic mucosa (P<0.00). However,changes in binding activity were not homogenous with approximately 50% of the tumors showing a clear increase in the binding activity, 30% displaying a modest increase and 15% showing a decrease of the activity.Tumors, with increased DNA-binding activity, also showed a statistically significant increase in Ku70 and Ku86nuclear expression, as determined by Western blot and immunohistochemical analyses (P<0.001). Cytoplasmic protein expression was found in pathological samples,but not in normal tissues either from tumor patients or from healthy subjects.CONCLUSION: Overall, our DNA-binding activity and protein level are consistent with a substantial activation of the NHEJ pathway in colorectal tumors. Since the NHEJ is an error prone mechanism, its abnormal activation can result in chromosomal instability and ultimately lead to tumorigenesis. | Paola Mazzarelli Paola Parrella Davide Seripa Emanuela Signori Giuseppe Perrone Carla Rabitti Domenico Borzomati Armando Gabbrielli Maria Giovanna Matera Carolina Gravina Marco Caricato Maria Luana Poeta Monica Rinaldi Sergio Valeri Roberto Coppola Vito Michele Fazio | 2005 | World Journal of Gastroenterology2005，11，42： | 4 |
| 3 | Nonpituitary Prolactin Gene Transcription is Independent of Pit-1 and Differentially Controlled in Lymphocytes and in Endometrial Stroma显示文摘 | Galetto A Geuna M | 1994 | J Mol Endocrinol1994，8，3： | 1 |
| 4 | Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with non-malignant diseases显示文摘 | Allard WJ Matera J Miller MC | 2004 | Clin Cancer Res2004，10，： | 1 |
| 5 | Polymorphism C in the serotonin transporter gene in depres- sion-free elderly patients with vascular dementia 显示文摘 | SERIPA D MATERA M G D'ONOFRIO G | 2010 | Dement Geriatr Cogn Disord2010，29，5： | 1 |
| 6 | Single-ineision laparoscopic ehole- cystectomy:surgery without a visible scar 显示文摘 | Tacchino R Greco F Matera D | 2009 | Surg Endosc2009，23，4： | 1 |
| 7 | Condom influence strategy questionnaire (CISQ) : a prelimi-nary study on the validation of an Italian version 显示文摘 | Stefanile C Matera C Nerini A at al | 2011 | Counseling2011，4，1： | 1 |
| 8 | Cazzola,oxidation pathway and exacerbations in COPD:the role of NAC显示文摘 | Matera MG | 2016 | Expert Rev Respir Med2016，10，1： | 1 |
| 9 | Crystal structure of the blue multicopper oxidase from the white-rot fungus trametes trogii complexed with p-toluate显示文摘 | Matera I Gullotto A Tilli S | 2008 | Inorg Chim Acta2008，361，14： | 1 |
| 10 | Pharmacokinetic study of the relative bioavailability and bioequivalence after oral intensive or repeated short term treatment with two polyamino acid formulations显示文摘 | Matera M Castana R Insirello L | 1993 | Int J Clin Pharmacol Res1993，13，2： | 1 |
| 11 | Expression of prolactin and prolactin receptors by non-Hodgkin's lymphoma cells显示文摘 | Matera L Geuna M Pastore C | 2000 | Int J Cancer2000，85，1： | 1 |
| 12 | The choice of the antigen in the dendritic cell-based vaccine therapy for prostate cancer 显示文摘 | Matera L | 2010 | Cancer Treat Rev2010，36，2： | 1 |
| 13 | Investigation of passive DMFC mini-stacks at ambient temperature显示文摘 | Baglio V Stassi A Matera F V | 2009 | Electrochemical Acta2009，54，7： | 1 |
| 14 | Tumor cells circulate in the peripheral blood of all major careinomas but not in healthy subjects or patients with nonmalignant diseases显示文摘 | Aliard WJ Matera J Miller MC | 2004 | Clio Cancer Res2004，10，20： | 1 |
| 15 | Pharmacological modulation of beta-adrenoceptor function in patients with coexisting chronic obstructive pulmonary disease and chronic heart failure显示文摘 | Matera M G Martuscelli E Cazzola M | 2010 | Pulm Pharmacol Ther2010，23，1： | 1 |
| 16 | Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases 显示文摘 | Allard WJ Matera J Miller MC | 2004 | Clin Cancer Res2004，10，： | 1 |
| 17 | Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases显示文摘 | Allard WJ Matera J Miller MC | 2004 | Clin Cancer Res2004，10，20： | 1 |
| 18 | Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases显示文摘 | Allard WJ Matera J Miller MC | 2004 | Clin Cancer Res2004，10，20： | 1 |
| 19 | Phenotypic and geno- typic evaluation of slime production by conventional and molecu-lar microbiological techniques 显示文摘 | Liberto MC Matera G Quirino A | 2009 | Microbiol Res2009，164，5： | 1 |
| 20 | Implications for renal disease显示文摘 | Matera M Bellinghieri G Costantino G et aLHistory of L-carnitine | 2003 | J Ren Nutr2003，13，1： | 1 |
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