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| 1 | Trans-arterial chemo-embolization is safe and effective for very elderly patients with hepatocellular carcinoma显示文摘AIM: To assess the safety and efficacy of trans-arterial chemo-embolization (TACE) in very elderly patients. METHODS: A prospective cohort study, from 2001 to 2010, compared clinical outcomes following TACE between patients ≥ 75 years old and younger patients (aged between 65 and 75 years and younger than 65 years) with hepatocellular carcinoma (HCC), diagnosed according to the European Association for the Study of the Liver and the American Association for the Study of Liver Diseases criteria. The decision that patients were not candidates for curative therapy was made by a multidisciplinary HCC team. Data collected included demographics, co-morbidities, liver disease etiology, liver disease severity and the number of procedures. The primary outcome was mortality; secondary outcomes included post-embolization syndrome (nausea, fever, abdominal right upper quadrant pain, increase in liver enzymes with no evidence of sepsis and with a clinical course limited to 3-4 d post procedure) and 30-d complications. Additionally, changes in liver enzyme measurements were assessed [alanine and aspartate aminotransferase (ALT and AST), gamma-glutamyl transpeptidase and alkaline phosphatase] in the week following TACE. Analysis employed both univariate and multivariate methods (Cox regression models). RESULTS: Of 102 patients who underwent TACE as sole treatment, 10 patients (9.8%) were > 80 years old at diagnosis; 13 (12.7%) were between 75 and 80 years, 45 (44.1%) were between 65 and 75 years and 34 (33.3%) were younger than 65 years. Survival analysis demonstrated similar survival patterns between the elderly patients and younger patients. Age was also not associated with the adverse event rate. Survival rates at 1, 2 and 3 years from diagnosis were 74%, 37% and 31% among patients < 65 years; 83%, 66% and 48% among patients aged 65 to 75 years; and 86%, 41% and 23% among patients ≥ 75 years. There were no differences between the age groups in the pre-procedural care, including preventive treatment for contrast nephropathy and prophylactic antibiotics. Multivariate survival analysis, controlling for disease stage at diagnosis with the Barcelona Clinic Liver Cancer score, number of TACE procedures, sex and alphafetoprotein level at the time of diagnosis, found no significant difference in the mortality hazard for elderly vs younger patients, and there were no differences in post-procedural complications. Serum creatinine levels did not change after 55% of the procedures, in all age groups. In 42% of all procedures, serum creatinine levels increased by no more than 25% above the baseline levels prior to TACE. Overall, there were 69 post-embolization events (23%). Hepatocellular enzymes often increased following TACE, with no association with prognosis. In 40% of the procedures, ALT and AST levels rose by at least 100%. The increases in hepatocellular enzymes occurred similarly in all age groups. CONCLUSION: TACE is safe and effective in very elderly patients with HCC, and is not associated with decreased survival or increased complication rates. | Matan J Cohen Allan I Bloom Orly Barak Alexander Klimov Tova Nesher Daniel Shouval Izhar Levi Oren Shibolet | 2013 | World Journal of Gastroenterology2013，19，16： | 13 |
| 2 | Secondary damage to the knee after isolated injury of the anterior cruciate ligament显示文摘 | Finsterbush A Frankl V Matan Y | 1990 | Am J Sports Med1990，18，4： | 1 |
| 3 | Creep of CMSX-4 superalloy single crystals:effects of rafting at high temperature显示文摘 | Reed R Matan N Cox D Rist M Rae C | 1999 | Acta Materialia1999，47，： | 1 |
| 4 | Creation of a fiber optic based biosensor for air toxicity monitoring显示文摘 | Evgeni E Vladislav P Matan B | | 0，，： | 1 |
| 5 | Super- resolution without explicit sub-pixel motion estimation 显示文摘 | HIROYUKI T PEYMAN M MATAN P | 2009 | IEEE Transaction on Image Processing2009，18，9： | 1 |
| 6 | Creep of CMSX~ superalloy single crystals: Effects of rafting at high temperature显示文摘 | Reed R C Matan N Cox D C | 1992 | Acta Metallurgicet Materialia1992，47，12： | 1 |
| 7 | On the kinetics of rafting in cmsx-4superalloy single crystals 显示文摘 | Matan N Cox D C Reed R C | 1999 | Acta Metallurgicet Materialia1999，47，7： | 1 |
| 8 | Creep of CMSX -4 superalloy single crystals effectsof misorientation ans temperature 显示文摘 | MATAN N | 1999 | Acta Mater1999，47，： | 1 |
| 9 | Super Resolution with Probabilistic Motion Estimation 显示文摘 | Matan Protter Michael Elad | 2009 | IEEE Transactions on Image Processing2009，18，8： | 1 |
| 10 | Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus显示文摘 | Albiol Matanic V C Castilla V | 2004 | Int J Antimicrob Agents2004，23，： | 1 |
| 11 | Antifungal activities of essential oils applied by dip-treatment on areca palm(Areca catechu)leaf sheath and persistence of their potency upon storage显示文摘 | Matan N Saengkrajang W Matan N | 2011 | International Biodeterioration and Biodegradation2011，65，1： | 1 |
| 12 | The Role of Stacking Fault Shear in the Primary Creep of - Oriented Single Crystal Superalloys at 750 ℃ and 750 MPa 显示文摘 | Rae C M F Matan N Reed R C | 2001 | Materials Science and Engineering2001，300，： | 1 |
| 13 | The Selectivity Effect of Past Experience on Purchasing Decisions: Implications for the WTA - WTP Disparity显示文摘 | Matan Tsur | 2008 | Journal of Economic Psychology2008，29，5： | 1 |
| 14 | Antifungal activities of essential oils applied by dip-treatment on areca palm (Areca catechu) leaf sheath and persistence of their potency upon storage显示文摘 | MATAN N SAENGKRAJANG W MATAN N | 2011 | International Biodeterioration & Biodegradation2011，65，1： | 1 |
| 15 | Antimicrobial activity of cinnamon and clove oils under modified atmosphere conditions显示文摘 | Matan N Rimkeeree H Mawson A J | 2006 | Int J Food Microbiol2006，107，2： | 1 |
| 16 | Antimicrobial acti- vity of cinnamon and clove oils under modified atmosphere con- ditions 显示文摘 | Matan N Rimkeeree H Mawson A J | 2006 | International Journal of Food Microbiology2006，107，： | 1 |
| 17 | Super resolution with probabilistic motion estimation 显示文摘 | Protter Matan Elad Michael | 2009 | IEEE Transactions on Image Processing2009，18，8： | 1 |
| 18 | Softening behavior of black sweet-bamboo (Dendrocalamus asper Backer) at various in- itial moisture contents显示文摘 | Matan N Kyokong B Preechatiwong W | 2011 | Walailak journal of science and tech- nology (WJST)2011，4，2： | 1 |
| 19 | On the primary creep of CMSX-4 superalloy single crystals 显示文摘 | Rae C M F Matan N Cox D C | 2000 | Me-tallurgical and Materials Transactions A2000，31，9： | 1 |
| 20 | Effect of preoperative feeding on gastric emptying following spinal anesthesia:a randomized controlled trial 显示文摘 | Protic A Turina D Matanic D | 2010 | wien Klin Wochenschr2010，122，12： | 1 |
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