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| 1 | Effects of Fuscoporia obliqua on Postprandial Glucose Excursion and Endothelial Dysfunction in Type 2 Diabetic Patients显示文摘Postprandial hyperglycemia has been reported to elicit endothelial dysfunction and provoke future cardiovascular complications. A reduction of postprandial blood glucose levels by the glucosidase inhibitor Fuscoporia obliqua was associated with a risk reduction of cardiovascular complications, but the effects of Fuscoporia obliqua on endothelial function have never been elucidated. This study is aimed to assess the efficacy of Fuscoporia obliqua on postprandial metabolic parameters and endothelial function in type 2 diabetic patients. Postprandial peak glucose (14.47±1.27 vs. 8.50±0.53 mmol/liter), plasma glucose excursion (PPGE), and change in the area under the curve (AUC) glucose after a single loading of test meal (total 450 kcal; protein 15.3%; fat 32.3%; carbohydrate 51.4%) were significantly higher in the diet-treated type 2 diabetic patients (n=14) than the age-and sex-matched controls (n=12). The peak forearm blood flow response and total reactive hyperemic flow (flow debt repayment) during reactive hyperemia, indices of resistance artery endothelial function on strain-gauge plethysmography, were unchanged before and after meal loading in the controls. But those of the diabetics were significantly decreased 120 and 240 min after the test meal. A prior administration of Fuscoporia obliqua decreased postprandial peak glucose, PPGE, and AUC glucose. The peak forearm blood flow and flow debt repayment were inversely well correlated with peak glucose, PPGE, and AUC glucose, but not with AUC insulin or the other lipid parameters. Even a single loading of the test meal was shown to impair the endothelial function in type 2 diabetic patients, and the postprandial endothelial dysfunction was improved by a prior use of Fuscoporia obliqua. Fuscoporia obliqua might reduce macrovascular complication by avoiding endothelial injury in postprandial hyperglycemic status. | Toshihiro Maenaka Masami Oshima Yuka Itokawa Takashi Masubuchi Yasuyuki Takagi Jung-Sook Choi Torao Ishida Yeunhwa Gu | 2008 | Journal of Traditional Chinese Medicine2008，28，1： | 4 |
| 2 | Loop-mediated isothermal amplification of DNA显示文摘 | Notomi T Okayama H Masubuchi H | 2000 | Nucleic Acids Res2000，28，12： | 1 |
| 3 | Reinvestigation of Phase Relations around the Oxyapatite Phase in the Nd2 O3-SiO2 System 显示文摘 | Yuji Masubuchi | 2003 | Journal of Crystal Growth2003，247，： | 1 |
| 4 | Single crystal growth and oxide ion conductivity of apatite-type rare-earth silicates显示文摘 | HIGUCHI M MASUBUCHI Y NAKAYAMA S | 2004 | Solid State Ionics2004，174，： | 1 |
| 5 | H∞ control for descriptor systems:a matrix inequalities approach显示文摘 | Masubuchi I Kamitane Y Ohara A | 1997 | Automatic1997，33，4： | 1 |
| 6 | Loop-mediated isothermal amplification of DNA显示文摘 | Notomi T Okayarma H Masubuchi H | | 0，，12： | 1 |
| 7 | Research activities examine residual stresses and distortion in welded structures显示文摘 | Koichi Masubuchi | 1991 | Welding Journal1991，，12： | 1 |
| 8 | Loop-mediated isothermal amplification of DNA显示文摘 | Notomi T Okayama H Masubuchi H | 2000 | Nucleic Acids Research2000，28，12： | 1 |
| 9 | Nonstoichiometry of phase relations around the oxyapatite phase in the Nd2O3-SiO2 system显示文摘 | MASUBUCHI Y HIGUCHI M KODAIRA K | 2003 | Journal of Crystal Growth2003，247，： | 1 |
| 10 | H∞ control for descriptor systems: a matrix inequalities approach显示文摘 | Masubuchi I Kamitane Y Ohara A | 1997 | Automatica1997，33，4： | 1 |
| 11 | Polymer显示文摘 | Masubuchi Y Watanabe K Nagatake W Takimoto J I Koyama K | 2001 | 42:5 0232001，42，： | 1 |
| 12 | Loop-mediated isothermal amplification of DNA 显示文摘 | Notomi T Okayama H Masubuchi H | 2000 | Nucleic Acids Res2000，28，12： | 1 |
| 13 | Immunological and genetic characterization of feline caliciviruses used in the development of a new trivalent inactivated vaccine in Japan显示文摘 | Masubuchi K Wakatsuki A Iwamoto K | 2010 | J Vet Med Sci2010，72，9： | 1 |
| 14 | Loop- mediated isothermal amplification of DNA显示文摘 | Notomi T Okayama H Masubuchi H | 2000 | Nucleic Acids Research2000，28，12： | 1 |
| 15 | Loop- mediated isothermal amplification of DNA 显示文摘 | Notomi T Okayama H Masubuchi H | 2000 | Nucleic Acids Research2000，28，12： | 1 |
| 16 | Loop-mediated isothermal amplification of DNA 显示文摘 | Notomi T Okayama H Masubuchi H | 2000 | Nucleic Acids Res2000，28，： | 1 |
| 17 | Management of patients with gynecologic cancer by serum sialic acid determination显示文摘 | Katsuhiko Hasumi Kazumasa Masubuchi | 1989 | Gynecol Oncol1989，33，： | 1 |
| 18 | Loop-mediated isothermal amplification of DNA显示文摘 | Notomi T Okayama H Masubuchi H | 2000 | Nucleic Acids Res2000，28，12： | 1 |
| 19 | loop-mediated isothermal amplification of DNA 显示文摘 | Notomi T Okayama H Masubuchi H | 2000 | Nucleic Acids Rcs2000，28，12： | 1 |
| 20 | Laser forming for flexible fabrication 显示文摘 | Koiehi Masubuchi Jerry E Jones | 2000 | Journal of Ship Production2000，16，2： | 1 |
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