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| 1 | 低社会经济地位与美国成年人早发冠状动脉粥样硬化性心脏病的关系显示文摘低社会经济地位(socioeconomic status,SES)的个体承担着不成比例的冠状动脉粥样硬化性心脏病(coronary heart disease,CHD)负担。在美国低收入地区,CHD仍然是死亡的主要原因。该研究旨在评估美国低SES个体的过量CHD负担,以及传统风险因素和与低SES相关因素影响所占的比例。 | Hamad R Penko J Kazi DS Coxson P Guzman D Pengxiao C.Wei Mason A Wang EA Goldman L Fiscella K Bibbins-Domingo K 周卫(译) 刘莉(审校) | 2020 | 中华高血压杂志2020，28，7： | 7 |
| 2 | Combination antiretroviral studies for patients with primary biliary cirrhosis显示文摘Following the characterization of a human betaretrovirus in patients with primary biliary cirrhosis(PBC),pilot studies using antiretroviral therapy have been conducted as proof of principal to establish a link of virus with disease and with the eventual aim to find better adjunct therapies for patients unresponsive to ursodeoxycholic acid.In the first open label pilot study,the reverse transcriptase inhibitor lamivudine had little demonstrable biochemical or histological effect after 1 year.Whereas,lamivudine in combination with zidovudine was associated with a significant reduction in alkaline phosphatase as well as improvement in necroinflammatory score,cholangitis and ductopenia over a 12 mo period.A double blind,multi-center randomized controlled trial using lamivudine with zidovudine for 6 mo confirmed a significant reduction in alkaline phosphatase,ALT and AST in patients on antiviral therapy.However,none of the patients achieved the stringent endpoint criteria for normalization of alkaline phosphatase.Furthermore,some patients developed biochemical rebound consistent with drug resistance.A major fault of these studies has been the inability to measure the viral load in peripheral blood and therefore,provide a direct correlation between improvement of hepatic biochemistry and reduction in viral load.Nevertheless,viral mutants to lamivudine with zidovudine were later characterized in the NOD.c3c4 mouse model of PBC that has been used to test other antiretroviral regimens to betaretrovirus.The combination of tenofovir and emtricitabine reverse transcriptase inhibitors and the HIV protease inhibitor,lopinavir were found to abrogate cholangitis in the NOD.c3c4 mouse model and the same regimen normalized the liver tests in a PBC patient with HIV and human betaretrovirus infection.This combination antiretroviral therapy has now been used in a double blind randomized controlled crossover study for patients with PBC followed by an open label extension study.Only a third of the PBC patients were able to tolerate the lopinavir but those maintained on tenofovir,emtricitabine and lopinavir experienced sustained and clinically meaningful reduction in hepatic biochemistry.While we await the histological and virological evaluation,it is clear that better tolerated regimens of antiretroviral treatment will be required in future clinical trials. | Ellina Lytvyak Aldo J Montano-Loza Andrew L Mason | 2016 | World Journal of Gastroenterology2016，22，1： | 2 |
| 3 | Design, synthesis, and anfiviral activity of 2'-deoxy- 2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication显示文摘 | CLARK L J HOLLECKER L MASON C J | 2005 | J Med Chem2005，48，17： | 1 |
| 4 | On the current status of quartz crystal microbalance studies of superconductivity-dependent sliding friction显示文摘 | MASON B L WINDER S M KRIM J | 2001 | Tribology Letters2001，10，12： | 1 |
| 5 | Characterizationand evolutionary analysis of Brassica species-divergedsequences containing simple repeat units 显示文摘 | WEI L J XIAO M L MASON A S | 2013 | Genes &Genomics2013，35，2： | 1 |
| 6 | Modelling tropical cyclone over-water wind and pressure fields 显示文摘 | McConochie J D Hardy T A Mason L B | 2004 | Ocean Engineering2004，31，13： | 1 |
| 7 | The management of peripheral blood cytopenias in systemic lupus erythematosus显示文摘 | Hepburn A L Narat S Mason J C | 2010 | Rheumatology(Oxford)2010，49，12： | 1 |
| 8 | Unconventional,highly selective CO2adsorption in zeolite SSZ-13显示文摘 | Hudson M R Queen W L Mason J A | 2012 | Journal of the American Chemical Society2012，134，4： | 1 |
| 9 | Zero-field splitting of Kondo Resonances in a Carbon Nanotube Quantum Dot显示文摘 | NYGRD J KOEHL W F MASON N L | | cond-mat/04104670，，： | 1 |
| 10 | Power comparisons for a Hotelling' s T2 statistic 显示文摘 | Chou Y M Mason R L Young J C | 1999 | Communications in Statistics Part B-Simulation and Computation1999，28，： | 1 |
| 11 | Long-range predictability of zimbabwe summer rainfall 显示文摘 | Unganai L S Mason S J | 2002 | International Journal of Climatology2002，22，9： | 1 |
| 12 | Methane gas hydrate effect on sediment acoustic and strength properties显示文摘 | Winters W J Waite W F Mason D H Gilbert L Y Pecher I A | | 0，，1： | 1 |
| 13 | Predicting RMS surface roughness using fractal dimension and PSD parameters 显示文摘 | Durst P J Mason G L McKinley B | 2011 | Journal of Terramechanics2011，48，2： | 1 |
| 14 | Improved generalization through explicit optimization of margins 显示文摘 | MASON L BARTLETT P L BAXTER J | 2000 | Machine Learning2000，38，3： | 1 |
| 15 | An error probability formula for mary DPSK in fast rician fading and gaussian noise显示文摘 | MASON L J | 1987 | IEEE Trans Comm1987，35，9： | 1 |
| 16 | Insulin-like grow factor (IGF) signaling through type 1 IGF receptor plays an important role in remyelination 显示文摘 | Mason J L Xuan S Dragatsis I | 2003 | J Neuoscience2003，23，20： | 1 |
| 17 | Latent root regression analysis显示文摘 | Webster J T Mason R L | 1974 | Technometrics1974，16，1： | 1 |
| 18 | Visualization of residual organic liquids trapped in aquifers显示文摘 | Conrad S H Wilson J L Mason W R | 1992 | Water Resources Research1992，28，： | 1 |
| 19 | Genomic DNApomethylation,a characteristic of most cancers,is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydro-folate reductase gene显示文摘 | Stren L L Mason J B Selhub J | 2000 | Cancer Epidemiol Biomarkers Prey2000，9，4： | 1 |
| 20 | fhe Pitman nearness criterion and determination 显示文摘 | Rao C R Neating J P Mason N L | 1986 | Commun Statist Theory and Methods1986，15，3： | 1 |
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