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| 1 | Segmentation of Hematoxylin-Eosin stained breast cancer histopathological images based on pixel-wise SVM classifier显示文摘Hematoxylin-Eosin(HE) staining is the routine diagnostic method for breast cancer(BC), and large amounts of HE stained histopathological images are available for analysis. It is emergent to develop computational methods to efficiently and objectively analyze these images, with the aim of providing potentially better diagnostic and prognostic information for BC. This work focuses on analyzing our in-house HE stained histopathological images of breast cancer tissues. Since tumor nests(TNs) and stroma morphological characteristics can reflect the biological behaviors of breast invasive ductal carcinoma(IDC), accurate segmentation of TNs and the stroma is the first step towards the subsequent quantitative analysis. We first propose a method based on the pixel-wise support vector machine(SVM) classifier for segmenting TNs and the stroma, then extract four morphological characters related to the TNs from the images and investigate their relationships with the patients' 8-year disease free survival(8-DFS). The evaluation result shows that the classification based segmentation method is able to distinguish between TNs and stroma with 87.1% accuracy and 80.2% precision,suggesting that the proposed method is promising in segmenting HE stained IDC histopathological images. The Kaplan-Meier survival curves show that three morphological characters(number of TNs, total perimeter, and average area of TNs) in the images have statistical correlations with 8-DFS of the patients, illustrating that the segmented images can help to identify new morphological factors in IDC TNs for the prediction of BC prognosis. | QU AiPing CHEN JiaMei WANG LinWei YUAN JingPing YANG Fang XIANG QingMing MASKEY Ninu YANG GuiFang LIU Juan LI Yan | 2015 | Science China(Information Sciences)2015，58，9： | 12 |
| 2 | 计算机图像分析挖掘乳腺癌病理预后新指标显示文摘应用计算机辅助图像分析方法研究了230例乳腺浸润性导管癌(invasive ductal carcinoma of the breast,IDC)的1 150张苏木素-伊红组织病理图像。用支持向量机模型分割上皮-间质,用标记点控制的分水岭算法分割细胞核,提取出730个形态学特征。Kaplan-Meier生存分析显示12个形态学特征与8年无病生存相关(P<0.05);Cox比例风险回归模型显示其中4个参数为独立预后因子:癌巢细胞密度(HR 1.645,95%CI[1.193,2.270],P=0.002)、间质细胞结构特征(HR 1.507,95%CI[1.084,2.095],P=0.015)、癌巢特征(HR 1.361,95%CI[1.026,1.804],P=0.032)及癌巢细胞核特征(HR 0.731,95%CI[0.538,0.993],P=0.045),可作为预测IDC预后的病理新指标。 | 陈佳梅 屈爱平 王林伟 袁静萍 杨芳 向清明 Ninu Maskey 杨桂芳 刘娟 李雁 | 2014 | 生物物理学报2014，0，7： | 2 |
| 3 | Effects of transition season management on soil N dynamics and system N balances in rice-wheat rotations of Nepal显示文摘 | Becker M Asch F Maskey S L | 2007 | Field Crops Research2007，103，： | 1 |
| 4 | Anti-cancer and antibacterial trioxacarcins with high anti-malaria activity from a marine streptomycete and their absolute stereochemistry 显示文摘 | Maskey R P Helmke E Kayser O | 2004 | J Antibiot2004，57，12： | 1 |
| 5 | Parimyein: Isolation and structure elucidation of a novel cytotoxie 2,3-di-hydro-quinizarin analogue of gamma-indomycinone from a marine streptomycete isolate 显示文摘 | Maskey R P Helmke E Fiebig H H | 2002 | J Antibiot2002，55，12： | 1 |
| 6 | Gutingimycin: A high complex metabolite from a marine streptomycete 显示文摘 | Maskey R P Sevvana M Uson I | 2004 | Angew Chem Int Ed2004，43，12： | 1 |
| 7 | 1-hydroxy-1-norresistomycin and resistoflavin methyl ether: New antibiotics from marine-derived streptomycetes 显示文摘 | Kock I Maskey R P Biabani M A F | 2005 | J Antibiot2005，58，8： | 1 |
| 8 | Parimycin:isolation and structure elucidation of a novel cytotoxic 2,3-dihydroquinizarin analogue of γ-indomycinone from a marine streptomycete isolate显示文摘 | Maskey R P Helmke E Laatsch H | 2002 | J Antibiot2002，55，12： | 1 |
| 9 | 1-Hydroxy-1-norresistomycin and resistoflavin methyl ether: new antibiotics from marine-derived Streptomycetes 显示文摘 | Kock I Maskey R P Farooq Biabani M A | 2005 | J Antibiot2005，58，8： | 1 |
| 10 | Patients' perceptions of physical activity before and after joint replacement: a systematic review with meta--ethnographic analysis 显示文摘 | Simth TO Latham S Maskey V | 2015 | Post- grad Med J2015，91，1079： | 1 |
| 11 | Trends in temperature and rainfall extremes in the Yellow River source region, China显示文摘 | Hu Y R Maskey S Uhlenbrook S | 2012 | Climatic Change2012，110，12： | 1 |
| 12 | Reducing specific phobialfear in young people with autism spectrum disorders (ASDs) through a virtual reality environment intervention显示文摘 | Maskey M Lowry J Rodgers J | 2014 | PLoS One2014，9，10： | 1 |
| 13 | Characterisation of individual aerosol particles collected during a haze episode in Incheon, Korea using the quantitative ED-EPMA technique 显示文摘 | Geng H Ryu J Y Maskey S | 2011 | Atmospheric Chemistry and Physics2011，11，3： | 1 |
| 14 | Characterization of individual aerosol particles collected during a haze episode in Incheon, Korea using the quantitative ED- EPMA technique 显示文摘 | Geng H Ryu J Maskey S | 2010 | Atmospheric Chemistry and Physics Discussions2010，10，26： | 1 |
| 15 | Hypothyroidism indiabetes mellitus patients in Eastern Nepal 显示文摘 | Maskey R Shakya DR Baranwal JK | 2015 | Indian J EtdocrinolMetab2015，19，3： | 1 |
| 16 | Downscaling daily precipita- tion over the Yellow River source region in China:A compari- son of three statistical downcaling methods显示文摘 | Hu Y R Maskey S Uhlenbrook S | 2013 | Theor Appl Climatol2013，112，： | 1 |
| 17 | An unusual presenta- tion of acute coronary syndrome 显示文摘 | Kohli SC Paraiuli M Maskey A | 2010 | J Nepal Health Res Counc2010，8，2： | 1 |
| 18 | Yield and soil fertility trends in a 20-year rice-rice-wheat experiment in Nepal显示文摘 | Regmi A P Ladha J K Pathak H Pasuquin E Bueno C Dawe D Hobbs P R Joshy D Maskey S L Pandey S P | 2002 | Soil Sei Soc Am J2002，66，： | 1 |
| 19 | Regionalization of a conceptual rainfall-runoff model based on similarity of the flow duration curve: a case study from the semi-arid Karkheh Basin, Iran显示文摘 | MASIH I UHLENBROOK S MASKEY S | 2010 | Journal of Hydrology2010，391，： | 1 |
| 20 | A study of risk factors of stroke in patients admitted in Manipal Teaching Hospital, Pokhara显示文摘 | Maskey A Parajuli M Kohli SC | 2011 | Kathmandu Univ Med J (KUMJ)2011，9，36： | 1 |
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