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| 1 | Micro RNA-320 family is downregulated in colorectal adenoma and affects tumor proliferation by targeting CDK6显示文摘AIM: To investigate the microR NA(miR NA) expression during histological progression from colorectal normal mucosa through adenoma to carcinoma within a lesion. METHODS: Using microarray, the sequential changes in miR NA expression profiles were compared in colonic lesions from matched samples; histologically, nonneoplastic mucosa, adenoma, and submucosal invasive carcinoma were microdissected from a tissue sample. Cell proliferation assay was performed to observe the effect of miR NA, and its target genes were predicted using bioinformatics approaches and the expression profile of SW480 transfected with the miR NA mimics. mR NA and protein levels of the target gene in colon cancer cell lines with a mimic control or miR NA mimics were measured using qR TPCR and Western blotting. The expression levels of miR NA and target gene in colorectal tissue samples were also measured.RESULTS: Microarray analysis identified that the miR-320 family, including miR-320 a, miR-320 b, miR-320 c, miR-320 d and miR-320 e, were differentially expressed in adenomaand submucosal invasive carcinoma. The mi R-320 family, which inhibits cell proliferation, is frequently downregulated in colorectal adenoma and submucosal invasive carcinoma tissues. Seven genes including CDK6 were identified to be common in the results of gene expression array and bioinformatics analyses performed to find the target gene of the miR-320 family. We confirmed that mR NA and protein levels of CDK6 were significantly suppressed in colon cancer cell lines with miR-320 family mimics. CDK6 expression was found to increase from non-neoplastic mucosa through adenoma to submucosal invasive carcinoma tissues and showed an inverse correlation with miR-320 family expression.CONCLUSION: MiR-320 family affects colorectal tumor proliferation by targeting CDK6, plays important role in its growth, and is considered to be a biomarker for its early detection. | Toshihiro Tadano Yoichi Kakuta Shin Hamada Yosuke Shimodaira Masatake Kuroha Yoko Kawakami Tomoya Kimura Hisashi Shiga Katsuya Endo Atsushi Masamune Seiichi Takahashi Yoshitaka Kinouchi Tooru Shimosegawa | 2016 | World Journal of Gastrointestinal Oncology2016，8，7： | 9 |
| 2 | Multi-Strategy Dynamic Spectrum Access in Cognitive Radio Networks: Modeling, Analysis and Optimization显示文摘Dynamic spectrum access(DSA) based on cognitive radios(CR) technique is an effective approach to address the 'spectrum scarcity' issue. However, traditional CR-enabled DSA system employs only single DSA strategy, which might not be suited to the dynamic network environment. In this paper, we propose a multi-strategy DSA(MS-DSA) system, where the primary and the secondary system share spectrum resources with multiple DSA strategies simultaneously. To analyze the performance of the proposed MS-DSA system, we model it as a continuous-time Markov chain(CTMC) and derive the expressions to compute the corresponding performance metrics. Based on this, we define a utility function involving the concerns of effective throughput, interference quantity on primary users, and spectrum leasing cost. Two optimization schemes, named as spectrum allocation and false alarm probability selection, are proposed to maximize the utility function. Finally, numerical simulations are provided to validate our analysis and demonstrate that the performance can be significantly improved caused by virtues of the proposed MS-DSA system. | Yi Yang Qinyu Zhang Ye Wang Takahiro Emoto Masatake Akutagawa Shinsuke Konaka | 2019 | China Communications2019，16，3： | 9 |
| 3 | Adaptive Resources Allocation Algorithm Based on Modified PSO for Cognitive Radio System显示文摘Radio spectrum has become a rare resource due to the rapid development of wireless communication technique. Cognitive radio is one of important techniques to deal with this radio spectrum problem. But the resource allocation in cognitive radio also has its own issues, such as the flexibility of the allocation algorithm, the performance of resource allocation, and so on. In order to increase the flexibility of the allocation algorithm for cognitive radio, more and more researches are focusing on the evolutionary algorithms, such as genetic algorithm(GA), particle swarm optimization(PSO). Evolutionary algorithm can greatly improve the flexibility of the allocation algorithm for cognitive radio system in different communication scenarios, but the performances are relatively lower than the original mathematical methods. So in this paper, we proposed an adaptive resource allocation algorithm based on modified PSO for cognitive radio system to solve these problems. Modified particle swarm optimization(Modified PSO) has both genetic algorithm(GA) and particle swarm optimization(PSO)’s updating processes which makes this modified PSO overcame PSO’s own disadvantages and keep advantages. Simulation results showed our proposed algorithm has enough flexibility to meet cognitive radio systems’ requirements, and also has a better performance than original PSO. | Yi Yang Qinyu Zhang Ye Wang Takahiro Emoto Masatake Akutagawa Shinsuke Konaka | 2019 | China Communications2019，16，5： | 9 |
| 4 | One-Step Synthesis of Magnetically Recyclable Au/Co/Fe Triple- Layered Core-Shell Nanoparticles as Highly Efficient Catalysts for the Hydrolytic Dehydrogenation of Ammonia Borane显示文摘有磁力地, recyclable Au/Co/Fe 核心壳 nanoparticles (NP ) 成功地在 situ 过程经由一出一步舞被综合了。传播电子显微镜(TEM ) ,精力散 X 光检查分光镜(版本) ,并且电子精力损失分光镜(鳗) 大小表明 trimetallic Au/Co/Fe NP 有三元组分层的核心壳结构一个 Au 核心,合作富人夹层,和 Fe 富有的壳镇静。Au/Co/Fe 核心壳 NP 为氨 borane 的 hydrolytic 除氢作用展出高得多的催化活动(NH3BH3, AB ) 比一金属(Au,公司, Fe ) 或二金属(AuCo, AuFe, CoFe ) 对应物。 | Kengo Aranishi Hai-Long Jiang Tomoki Akita Masatake Haruta Qiang Xu | 2011 | Nano Research2011，4，12： | 8 |
| 5 | Exenatide improves hepatic steatosis by enhancing lipid use in adipose tissue in nondiabetic rats显示文摘AIM:To investigate the metabolic changes in skeletal muscle and/or adipose tissue in glucagon-like peptide-1-induced improvement of nonalcoholic fatty liver disease(NAFLD).METHODS:Male Wistar rats were fed either a control diet(control group)or a high-fat diet(HFD).After 4wk,the HFD-fed rats were subdivided into two groups;one group was injected with exenatide[HFD-Ex(+)group]and the other with saline[HFD-Ex(-)group]every day for 12 wk.The control group received saline and were fed a control diet.Changes in weight gain,energy intake,and oxygen consumption were analyzed.Glucose tolerance tests were performed after 8 wk of treatment.Histological assessments were performed in liver and adipose tissue.RNA expression levels of lipid metabolism related genes were evaluated in liver,skeletal muscle,and adipose tissue.RESULTS:Exenatide attenuated weight gain[HFDEx(-)vs HFD-Ex(+)]and reduced energy intake,which was accompanied by an increase in oxygen consumption and a decrease in the respiratory exchange ratio[HFD-Ex(-)vs HFD-Ex(+)].However,exenatide did not affect glucose tolerance.Exenatide reduced lipid content in the liver and adipose tissue.Exenatide did not affect the expression of lipid metabolism-related genes in the liver or skeletal muscle.In adipose tissue,exenatide significantly upregulated lipolytic genes,including hormone-sensitive lipase,carnitine palmitoyltransferase-1,long-chain acyl-CoA dehydrogenase,and acyl-CoA oxidase 1[HFD-Ex(-)vs HFD-Ex(+)].Exenatide also upregulated catalase and superoxide dismutase 2[HFD-Ex(-)vs HFD-Ex(+)].CONCLUSION:In addition to reducing appetite,enhanced lipid use by exenatide in adipose tissue may reduce hepatic lipid content in NAFLD,most likely by decreasing lipid influx into the liver. | Kosuke Tanaka Yuko Masaki Masatake Tanaka Masayuki Miyazaki Munechika Enjoji Makoto Nakamuta Masaki Kato Masatoshi Nomura Toyoshi Inoguchi Kazuhiro Kotoh Ryoichi Takayanagi | 2014 | World Journal of Gastroenterology2014，20，10： | 6 |
| 6 | Assessing pre/post-weaning neurobehavioral development for perinatal exposure to low doses of methylmercury显示文摘Fetuses and neonates are known to be high-risk groups for Methylmercury(MeHg)exposure.MeHg can be transferred to the fetus through the placenta and to newborn offspring through breast milk.The aim of the present study was to investigate the neurotoxic effects of low doses of MeHg(1 and 5 μg/m L in drinking water) administration,from gestational day 1 to postnatal day(PND) 21,on the neurobehavioral development of rats.The results showed that the no-observed-effect level of MeHg is somewhere in the range of 1–4 μg/mL.Neurobehavioral development analysis revealed a delayed appearance of cliff drop and negative geotaxis reflexes in the 5 μg/mL MeHg exposure group.Developmental exposure to MeHg affected locomotor activity functions for the females,but not for the males,implying that the female pups were more vulnerable than the male pups.All pups exposed to 5 μg/mL of MeHg showed a significant deficit in motor coordination in the rotarod test compared with controls,and the highest accumulated concentrations of Hg were found in the cerebellum,followed by the hippocampus and cerebral cortex,indicating that the cerebellum is a possible target for MeHg toxicity.We demonstrated adverse effects of developmental exposure to MeHg associated with tissue concentrations very close to the current human body burden of this persistent and bioaccumulative compound. | Jinping Cheng Masatake Fujimura Dandan Bo | 2015 | Journal of Environmental Sciences2015，27，12： | 6 |
| 7 | 负载金催化剂上CO氧化反应活性与金属氧化物载体中金属-氧结合能之间的关系(英文)显示文摘讨论了金属氧化物载体(MO_x)对其负载纳米金催化剂(Au/MO_x)上CO氧化反应的影响.采用典型的共沉淀法和沉积-沉淀法在完全相同的焙烧条件下制备了一系列MO_x负载金催化剂,以CO氧化转化50%时的反应温度(T_(1/2))定量评价了MO_x载体和Au/MO_x催化剂的催化活性.进一步将MO_x载体与相应Au/MO_x催化剂的T_(1/2)值之差对MO_x载体的金属-氧结合能做曲线进行关联,发现二者呈明显的火山型关系.这一结果表明,采用具有适当金属-氧结合能(300–500 atom O)的MO_x可大大提高沉积于其上的Au纳米颗粒的催化活性. | Takashi Fujita Masanori Horikawa Takashi Takei Tom Murayama Masatake Haruta | 2016 | Chinese Journal of Catalysis2016，37，10： | 3 |
| 8 | 牛奶中有机磷农药残留量简便分析法显示文摘鲜奶及奶制品中常含有有机磷农药残留,这主要是由于饲料在收获前用此类农药处理所致。国际乳制品联合会希望研制出一种测定牛奶中有机磷农药残留量的简便方法,但迄今未见报道。最近,有人提出一种测定糙米中有机磷农药的简便方法,即采用乙腈提取,用醋酸锌去除脂肪,抽滤后,再经二氯甲烷重复萃取,然后用配有大口径毛细管色谱柱及火焰光度检测器的气相色谱仪测定有机磷农药的含量。 | Masatake Toyoda 默涛 | 1992 | 农药译丛1992，14，2： | 3 |
| 9 | Antithrombin Ⅲ injection via the portal vein suppresses liver damage显示文摘AIM:To investigate the effects of antithrombin Ⅲ(AT Ⅲ) injection via the portal vein in acute liver failure.METHODS:Thirty rats were intraperitoneally challenged with lipopolysaccharide(LPS) and D-galactosamine(GalN) and divided into three groups:a control group;a group injected with AT Ⅲ via the tail vein;and a group injected with AT Ⅲ via the portal vein.AT Ⅲ(50 U/kg body weight) was administrated 1 h after challenge with LPS and GalN.Serum levels of inflammatory cytokines and fibrin degradation products,hepatic fibrin deposition,and hepatic mRNA expression of hypoxiarelated genes were analyzed.RESULTS:Serum levels of alanine aminotransferase,tumor necrosis factor-α and interleukin-6 decreased significantly following portal vein AT Ⅲ injection compared with tail vein injection,and control rats.Portal vein AT Ⅲ injection reduced liver cell destruction and decreased hepatic fibrin deposition.This treatment also significantly reduced hepatic mRNA expression of lactate dehydrogenase and heme oxygenase-1.CONCLUSION:A clinically acceptable dose of AT Ⅲ injection into the portal vein suppressed liver damage,probably through its enhanced anticoagulant and antiinflammatory activities. | Masayuki Miyazaki Masaki Kato Masatake Tanaka Kosuke Tanaka Shinichiro Takao Motoyuki Kohjima Tetsuhide Ito Munechika Enjoji Makoto Nakamuta Kazuhiro Kotoh Ryoichi Takayanagi | 2012 | World Journal of Gastroenterology2012，18，16： | 2 |
| 10 | 钢帘线钢丝索氏体化处理条件对拉拔期间中心裂纹的影响显示文摘弄清楚导致拉拔期间“中心裂纹”的内部缺陷,要比弄清表面缺陷如过热和划痕困难,因此,当钢丝拉断且操作中断时,仅认为是中心裂纹造成的。钢丝如果没拉断,内部裂纹像一个箭头状遗留在产品内(照片1)。 | Masatake Tomita Takashi Tsukamoto Chuzo Sudo Terutaka Tsumura 孙留根 | 1993 | 金属制品1993，，A11： | 2 |
| 11 | 沉积-沉淀法和沉积-还原法制备Nb_2O_5负载的金纳米粒子及其催化CO氧化活性(英文)显示文摘采用不同的沉积法制备了氧化铌(Nb_2O_5)负载的金纳米粒子催化剂,即沉积-沉淀(DP)法、尿素辅助的DP法、沉积-还原(DR)法和一步法制备了1 wt%Au/Nb_2O_5催化剂.在众多类型Nb_2O_5(包括商业Nb_2O_5)中,采用水热法制备的层间型Nb_2O_5(Nb_2O_5(HT))最适合用作载体.结果表明,较大比表面积的Nb_2O_5(HT)使得金以纳米颗粒形式分散于其上.在优化的条件下,以DP和DR法沉积于Nb_2O_5(HT)上的金纳米粒子平均粒径为5 nm.采用DR法制备的Au/Nb_2O_5(HT)催化剂上CO转化率为50%时的温度为73 oC.不沉积金的条件下,即使在250 oC,Nb_2O_5(HT)对CO氧化反应也没有催化活性.因此,金的沉积对活性的促进作用非常明显.该简易Au/Nb_2O_5催化剂将金催化剂的类型扩展到酸性载体,这将增加新的应用. | Toru Murayama Masatake Haruta | 2016 | Chinese Journal of Catalysis2016，37，10： | 2 |
| 12 | Increased hepatic expression of dipeptidyl peptidase-4 in non-alcoholicfatty liver disease and its association with insulin resistance and glucose metabolism显示文摘 | Masayuki Miyazaki Masaki Kato Kosuke Tanaka Masatake Tanaka Motoyuki Kohjima Kazuhiko Nakamura Munechika Enjoji Makoto Nakamuta Kazuhiro Kotoh Ryoichi Takayanagi | 2012 | Molecular Medicine Reports2012，，3： | 2 |
| 13 | Size-and support-depeddency in the catalysis of gold显示文摘 | MASATAKE H | 1997 | Catalysis Today1997，36，： | 1 |
| 14 | DFT studies of interaction between 02 and Au clusters: The rule of anionic surface Au atoms on Au clusters for catalyzed oxygenation显示文摘 | MITSUTAKAO YASUTAKA K MASATAKE H | 2001 | Chemical Physics Letters2001，346，： | 1 |
| 15 | The Role of Barents Sea Ice in the Wintertime Cyclone Track and Emergence of a Warm-Arctic Cold-Siberian Anomaly显示文摘 | Inoue Jun Hori Masatake E Takaya Koutarou | 2012 | EN2012，，7： | 1 |
| 16 | Simulator for Coal Liquefaction Based on the NEDOL Process显示文摘 | Itoh H Masatake Kidoguchi A | 2001 | Industrial & Engineering Chemistry Research2001，40，1： | 1 |
| 17 | Catalysis of Gold Nanoparticles Deposited on Metal Oxides显示文摘 | Masatake Haruta | 2002 | CATTECH2002，，3： | 1 |
| 18 | Effect of atrial septal pacing on p-wave duration dispersion and atrial late potentials in patients with paroxysmal atrial fibrillation显示文摘 | Takahisa Y Masatake F Tsuyoshi S | 2001 | Am J Cardiol2001，88，： | 1 |
| 19 | Oxide Inclusion Control in Ladle and Tundish for Producing Clean Stainless Steel显示文摘 | Hojo Masatake Nakao Ryuji Umezaki Tsuyoshi | 1996 | ISIJ1996，，： | 1 |
| 20 | Synthesis and properties of lead picrates显示文摘 | Makoto M Takehiro M Masatake Y | 2004 | Science and Technology of Energetic Materials2004，65，1： | 1 |
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