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| 1 | Simultaneous large cell neuroendocrine carcinoma and adenocarcinoma of the stomach显示文摘A large cell neuroendocrine carcinoma(LCNEC) of the stomach is very rare.A 76-year-old Japanese man was admitted to our hospital because of epigastralgia and nausea.Endoscopy revealed 2 large tumors in the stomach.He did not have multiple endocrine neoplasia typeⅠor Zollinger-Ellison syndrome.Imaging modalities,including computed tomography and magnetic resonance imaging,revealed no other tumors.Gastrectomy,cholecystectomy,and lymph node dissection were performed.The resected stomach had 2 tumors:one was an antral ulcerated type 3 tumor measuring 5 cm x 5 cm,and the other was a polypoid type 1 tumor measuring 6 cm x 6 cm x 3 cm in the fundus.Microscopically,the antral ulcerated tumor was a well differentiated adenocarcinoma with deep invasion.The fundus polypoid tumor was a LCNEC,being composed of malignant large cells arranged in trabecular and nested patterns.The tumor cells were large and the nuclei were vesicular.Nucleoli were frequently present,and there were many mitotic figures,apoptotic bodies,and necrotic areas.Much lymphovascular permeation was seen.Seven out of 29 dissected lymph nodes showed metastatic foci;6 were from the LCNEC and 1 from theadenocarcinoma.Many intravascular tumor emboli of LCNEC were seen in the peritoneum around the lymph nodes.Mucins were present in the adenocarcinoma but not in the LCNEC.Immunohistochemically,the LCNEC tumor cells were positive for pancytokeratins,synaptophysin(50%positive) ,chromogranin A(10% positive) ,Ki-67(90%labeled) ,and platelet-derived growth factor-α(80%positive) .They were negative for KIT,p53,CD56,and neuron-specific enolase.The non-cancerous stomach showed a normal number of endocrine cells.The patient is now treated with adjuvant chemotherapy. | Tadashi Terada Hirotoshi Maruo | 2011 | World Journal of Gastroenterology2011，17，43： | 5 |
| 2 | Esophageal combined carcinomas:Immunohoistochemical and molecular genetic studies显示文摘Primary esophageal combined carcinoma is very rare.The authors herein report 2 cases.Case 1 was a combined squamous cell carcinoma and small cell carcinoma,and case 2 was a combined squamous cell carcinoma,adenocarcinoma,and small cell carcinoma.Case 1 was a 67-year-old man with complaints of dysphagia.Endoscopic examination revealed an ulcerated tumor in the middle esophagus,and 6 biopsies were obtained.All 6 biopsies revealed a mixture of squamous cell carcinoma and small cell carcinoma.Both elements were positive for cytokeratin,epithelial membrane antigen,and p53 protein,and had high Ki-67 labeling.The small cell carcinoma element was positive for synaptophysin,CD56,KIT,and platelet-derived growth factor-α(PDG-FRA),while the squamous cell carcinoma element was not.Genetically,no mutations of KIT and PDGFRA were recognized.The patient died of systemic carcinomatosis 15 mo after presentation.Case 2 was a 74-year-old man presenting with dysplasia.Endoscopy revealed a polypoid tumor in the distal esophagus.Seven biopsies were taken,and 6 showed a mixture of squamous cell carcinoma,small cell carcinoma,and adenocarcinoma.The 3 elements were positive for cytokeratins,epithelial membrane antigen,and p53 protein,and had high Ki-67 labeling.The adenocarcinoma element was positive for mucins.The small cell carcinoma element was positive for CD56,synaptophysin,KIT,and PDGFRA,but the other elements were not.Mutations of KIT and PDGFRA were not recognized.The patient died of systemic carcinomatosis 7 mo after presentation.These combined carcinomas may arise from enterochromaffin cells or totipotential stem cell in the esophagus or transdifferentiation of one element to another.A review of the literature was performed. | Tadashi Terada Hirotoshi Maruo | 2012 | World Journal of Gastroenterology2012，18，13： | 4 |
| 3 | Insulin-like growth factor I as a local regulator of proliferation and differentiated function of the human trophoblast in early pregnancy显示文摘 | Maruo T Murata k Matsuo H | 1995 | Early Pregnancy1995，1，1： | 1 |
| 4 | Effects of progesterone on growth factor expression in human uterine leiomyoma显示文摘 | MARUO T MATSUO H SAMOI' O T | 2003 | Steroids2003，68，1013： | 1 |
| 5 | Improvement of partial least squares models for in vitro and in vivo glucose quantifications by using near-infrared spectroscopy and searching combination moving window partial least squares显示文摘 | KASEMSUMRAN S DU Y P MARUO K | 2006 | Chemometrics and Intelligent Laboratory Systems2006，82，： | 1 |
| 6 | Decreased expression of epidermal growth factor and its receptor in the malignant transformation of trophoblasts显示文摘 | Ladines-Llave C A Maruo T Manalo A M | 1993 | Cancer1993，71，12： | 1 |
| 7 | Effects of progesterone on growth factor expression in human uterine leiomyoma显示文摘 | Maruo T Matsuo H Shimomura Y | 2003 | Steroids2003，68，1013： | 1 |
| 8 | Submicron manipulation tool drivenby light in a liquid显示文摘 | Maruo S | | 0，，： | 1 |
| 9 | Proximal junctional kyphosis and clinical outcomes in adult spinal deformity surgery with fusion from the thoracic spine to the sacrum:a comparison of proximal and distal upper instrumented vertebrae显示文摘 | Ha Y Maruo K Racine L | 2013 | J Neurosurg Spine2013，19，3： | 1 |
| 10 | Vasohibin-1 as a potential predictor of aggressive behavior of ductal carcinoma in situ of the breast显示文摘 | Tamaki K Sasano H Maruo Y | 2010 | Cancer Sci2010，101，4： | 1 |
| 11 | Antenatal use of ambroxol for the prevention of infant respiratory distress syndrome显示文摘 | Laoag - Fernandez JB Fernandez AM Maruo T | 2000 | J Obstet Gynaecol Res2000，26，4： | 1 |
| 12 | Lymph node metastasis of gastric cancer显示文摘 | Maruo T konishi Y | 2002 | Jpn J cancer2002，98，： | 1 |
| 13 | Immunohistochemical localization of epidermal growth factor receptor and myc oncogene product in human placenta: implication for trophoblast proliferation and differentiation显示文摘 | Maruo T Mochizuki M | 1987 | Am J Obstet Gynecol1987，156，3： | 1 |
| 14 | Increased expression of Bcl-2 protein in human uterine leiomyoma and its up-regulation by progesterone显示文摘 | Matsuo H Maruo T Samoto T | 1997 | J Clin Endocrinol Metab1997，82，1： | 1 |
| 15 | Moran line ( 1-deoxynojiri- mycin) fermentation and its improvement 显示文摘 | Ezure Y Maruo S Miyazaki K | 1985 | Agric Biol Chem1985，49，4： | 1 |
| 16 | Clinical features and surgery for acquired progressive esotropia associated with severe myopia显示文摘 | Hayashi T Iwashige H Maruo T | 1999 | Acta Ophthalmol Scand1999，77，1： | 1 |
| 17 | Invovlement of bradykinin generation in intravascular disssemination and prevention of invasion by a bradykinin antagonist显示文摘 | Keishi Maruo Takaaki Tomomichi Ono | 1998 | Infect Immune1998，66，2： | 1 |
| 18 | Tumor associated antigen, TA-4, in the monitoring of the effects of therapy for squamous cell carcinoma of the uterine cervix:Serial determinations and tissue localization 显示文摘 | Maruo T Shibatu K Kimura A | 1985 | Cancer1985，，56： | 1 |
| 19 | Gingival overgrowth in a dog that received long-term cyclosporine for immune-mediated hemolytic anemia显示文摘 | Namikawa K Maruo T Honda M Hirata H Lynch J Madarame H | 2012 | Can Vet J2012，53，： | 1 |
| 20 | Femtosecond laser direct writing of metallic microstructures by photoreduction of silver nitrate in a polymer matrix显示文摘 | MARUO S SAEKI T | 2008 | Optics Express2008，16，2： | 1 |
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