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| 1 | Gut hormones, and short bowel syndrome: The enigmatic role of glucagon-like peptide-2 in the regulation of intestinal adaptation显示文摘Short bowel syndrome (SBS) refers to the malabsorption of nutrients, water, and essential vitamins as a result of disease or surgical removal of parts of the small intestine. The most common reasons for removing part of the small intestine are due to surgical intervention for the treatment of either Crohn's disease or necrotizing enterocolitis. Intestinal adaptation following resection may take weeks to months to be achieved, thus nutritional support requires a variety of therapeutic measures, which include parenterai nutrition. Improper nutrition management can leave the SBS patient malnourished and/or dehydrated, which can be life threatening. The development of therapeutic strategies that reduce both the complications and medical costs associated with SBS/long-term parenterai nutrition while enhancing the intestinal adaptive response would be valuable. Currently, therapeutic options available for the treatment of SBS are limited. There are many potential stimulators of intestinal adaptation including peptide hormones, growth factors, and neuronally-derived components. Glucagon-like peptide-2 (GLP-2) is one potential treatment for gastrointestinal disorders associated with insufficient mucosal function. A significant body of evidence demonstrates that GLP-2 is a trophic hormone that plays an important role in controlling intestinal adaptation. Recent data from clinical trials demonstrate that GLP-2 is safe, well-tolerated, and promotes intestinal growth in SBS patients. However, the mechanism of action and the localization of the glucagon-like peptide-2 receptor (GLP-2R) remains an enigma. This review summarizes the role of a number of mucosal-derived factors that might be involved with intestinal adaptation processes; however, this discussion primarily examines the physiology, mechanism of action, and utility of GLP-2 in the regulation of intestinal mucosal growth. | GR Martin PL Beck DL Sigalet | 2006 | World Journal of Gastroenterology2006，12，26： | 3 |
| 2 | Circulating giant macrophages as a potential biomarker of solid tumors显示文摘 | Adams DL Martin SS Mpaugh RK | 2014 | Proc Natl Acad Sci U S A2014，111，： | 1 |
| 3 | Genetic variation in IL28B and spontaneous clearance of hepatitis C virus显示文摘 | Thomas DL Thio CL Martin MP | 2009 | Nature2009，461，7265： | 1 |
| 4 | 查看详情显示文摘 | Sacks D Marinelli DL Martin LG | | 0，，： | 1 |
| 5 | Health care expenditures associated with autism spectrum disorders显示文摘 | Leslie DL Martin A | 2007 | Arch pediatr Adolesc Med2007，161，4： | 1 |
| 6 | Genetic variation in IL28B and spontaneous clearance of hepatitis C virus 显示文摘 | Thomas DL Thio CL Martin MP | 2009 | Nature2009，461，7265： | 1 |
| 7 | N-methy-D-aspartate receptor proteins NMDA-2A and NMDA-2 Bare differentially distributed in the developing rat central nervous system as revealed by subunit-speeific antibodies显示文摘 | Portera-Cailliau C Price DL Martin LJ | 1996 | J Neurochem1996，66，： | 1 |
| 8 | Increased platelet aggregability associated with platelet GP Ⅲ a PIA2 polymorphism:the Framingham Offspring Study显示文摘 | Feng DL Klaus L Martin GL | 1999 | Arterioscler Thromb Vase Bio11999，19，4： | 1 |
| 9 | Quality of life of women with urinary incontinence:further development of the incontinence quality of life instrument (I-QOL)显示文摘 | Patrick DL Martin ML Bushnell DM | | 0，，： | 1 |
| 10 | Annual sum- mary of vital statistics : 2010-2011 显示文摘 | Hamilton BE Hoyert DL Martin JA | 2013 | Pediatrics2013，131，3： | 1 |
| 11 | Catabolic effects of contin-uous human PTH (1--38) in vivo is associated with sustained stimulation of RANKL and inhibition of osteoprotegerin and gene-associated bone formation显示文摘 | Ma YL Cain RL Halladay DL Yang X Zeng Q Miles RR Chandrasekhar S Martin TJ Onyia JE | | 0，，： | 1 |
| 12 | Cultural adaptation of a quality of life measure for urinary incontinence显示文摘 | Patrick DL Martin ML Bushnell DM | 1999 | Eur Urol1999，36，： | 1 |
| 13 | Genetic and environmental risk factors for asthma:a cotwin-control study显示文摘 | Duffy DL Mitchell CA Martin NG | 1998 | Am J Respir Crit Care Med1998，157，： | 1 |
| 14 | Environmental tobacco smoke (ETS):a market cigarette study显示文摘 | Martin P Heavner DL Nelson PR | 1997 | Environment International1997，23，1： | 1 |
| 15 | Short-Term Intravenous Fish-Oil Emulsions in Pediatric Oncologic Patients—Effect on Liver Parameters显示文摘 | K. Martin Hoffmann Michael Grabowski Siegfried R?dl Andrea Deutschmann Gerold Schwantzer Petra Sovinz Volker Strenger Christian Urban Wolfgang Muntean Almuth C. Hauer | 2014 | Nutrition and Cancer2014，，6： | 1 |
| 16 | N-methyl-D-aspartate re- ceptor proteins NR2A and NR2B are differentially distributed in the developing rat central nervous system as revealed by subunit-specific antibodies显示文摘 | Portera-Cailliau C Price DL Martin LJ | 1996 | Neuroebem1996，66，： | 1 |
| 17 | Individual memory change after anterior temporallobectomy a base rate analysis using regressing-based outcome methodology显示文摘 | Sawrie SM Roth DL | 1998 | Epilepsia1998，19，2： | 1 |
| 18 | Genetic variation in IL-28B and to spontaneous clearance of hepatitis C virus显示文摘 | Thomas DL Thio CL Martin MP | 2009 | Nature2009，461，7265： | 1 |
| 19 | Effects of denosumab treatment and discontinuation on bone mineral density and bone turnover markers in postmenopausal women with low bone mass显示文摘 | Bone HG Bolognese MA Yuen CK Kendler DL Miller PD Yang YC Grazette L San Martin J Gallagher JC | | 0，，： | 1 |
| 20 | Quality of life of women with urinary incontinence:further development of the incontinence quality of life instrument(I-QOL)显示文摘 | Patrick DL Martin ML Bushnell DM | 2009 | Urol2009，53，1： | 1 |
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