|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Distinct memory traces for two visual features in the Drosophila brain显示文摘 | Gang Liu Holger Seiler Ai Wen Troy Zars Kei Ito Reinhard Wolf Martin Heisenberg Li Liu | 2006 | 中国生物学文摘2006，20，3： | 17 |
| 2 | Hijacking antibody-induced CTLA-4 lysosomal degradation for safer and more effective cancer immunotherapy显示文摘It remains unclear why the clinically used anti-CTLA-4 antibodies, popularly called checkpoint inhibitors, have severe immunotherapy-related adverse effects (irAEs) and yet suboptimal cancer immunotherapeutic effects (CITE). Here we report that while irAE-prone Ipilimumab and TremeIgG1 rapidly direct cell surface CTLA-4 for lysosomal degradation, the non-irAE-prone antibodies we generated, HL12 or HL32, dissociate from CTLA-4 after endocytosis and allow CTLA-4 recycling to cell surface by the LRBA-dependent mechanism. Disrupting CTLA-4 recycling results in robust CTLA-4 downregulation by all anti-CTLA-4 antibodies and confers toxicity to a non-irAE-prone anti-CTLA-4 mAb. Conversely, increasing the pH sensitivity of TremeIgG1 by introducing designed tyrosine-to-histidine mutations prevents antibody-triggered lysosomal CTLA-4 downregulation and dramatically attenuates irAE. Surprisingly, by avoiding CTLA-4 downregulation and due to their increased bioavailability, pH-sensitive anti-CTLA-4 antibodies are more effective in intratumor regulatory T-cell depletion and rejection of large established tumors. Our data establish a new paradigm for cancer research that allows for abrogating irAE while increasing CITE of anti-CTLA-4 antibodies. | Yan Zhang Xuexiang Du Mingyue Liu Fei Tang Peng Zhang Chunxia Ai James K. Fields Eric J. Sundberg Olga S. Latinovic Martin Devenport Pan Zheng Yang Liu | 2019 | Cell Research2019，29，8： | 6 |
| 3 | 多器官床旁即时超声在新型冠状病毒肺炎中的应用:国际专家共识显示文摘新型冠状病毒肺炎(简称新冠肺炎,COVID-19)自首次报道以来,已造成全球超一亿人感染,给各国的公共卫生体系造成了巨大威胁。新冠肺炎的临床表现以呼吸系统体征和症状为主,80%的患者症状轻微,约5%为危重症患者,常表现为急性呼吸窘迫综合征(ARDS)。前期,由于缺乏相关研究,面对日益紧迫的临床困境,医务人员不得不借鉴采取一些经验性措施以应对疫情。 | 王臻(译) Arif Hussain Gabriele Via Lawrence Melniker Alberto Goffi Guido Tavazzi Luca Neri Tomas Villen Richard Hoppmann Francesco Mojoli Vicki Noble Laurent Zieleskiewicz Pablo Blanco Irene W.Y.Ma Mahathar Abd.Wahab Abdulmohsen Alsaawi Majid AI Salamah Martin Balik Diego Barca Karim Bendjelid Belaid Bouhemad Pablo Bravo-Figueroa Raoul Breitkreutz Juan Calderon Jim Connolly Roberto Copetti Francesco Corradi Anthony J.Dean AndréDenault Deepak Govil Carmela Graci Young-Rock Ha Laura Hurtado Toru Kameda Michael Lanspa Christian B Laursen Francis Lee Rachel Liu Massimiliano Meineri Miguel Montorfano Peiman Nazerian Bret P.Nelson Aleksandar N.Neskovic Ramon Nogue Adi Osman JoséPazeli Elmo Pereira-Junior Tomislav Petrovic Emanuele Pivetta Jan Poelaert Susanna Price Gregor Prosen Shalim Rodriguez Philippe Rola Colin Royse Yale Tung Chen Mike Wells Adrian Wong Wang Xiaoting Wang Zhen Yaseen Arabi | 2021 | 中国呼吸与危重监护杂志2021，20，2： | 5 |
| 4 | Efficacy and safety of d, 1-sotalol in patients with ventricular tachycardia and in survivors of cardiac arrest显示文摘 | Haverkamp W Martines RA Hief C et ai | 1997 | J Am Coll Cardiol1997，30，： | 1 |
| 5 | Cure chemorheology of mixtures based on epoxy resins and ester cyanaters显示文摘 | Martin M D Ormaetxea M Harismendy I et aI | 1999 | Euro Polym J1999，35，1： | 1 |
| 6 | Regulation of heine oxygenase - 1 expression through the phosphatidylinositol 3 -kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol 显示文摘 | Martin D Rojo AI Salinas M | 2004 | Biol Chem2004，279，10： | 1 |
| 7 | Posttransplantation production of donor HLA-specific antibodies as a predictor of renal transplant outcome显示文摘 | WORTHINGTON J E MARTIN S AI HUSSEINI D M | 2003 | Transplantation2003，75，7： | 1 |
| 8 | Denosumab for prevention of fractures in postmenopausal women with osteoporosis显示文摘 | Cummings SR San Martin J McClung MR et ai | 2009 | Obestetrical&Gynecdogical Survey2009，64，12： | 1 |
| 9 | Interpretation and Implementation of Intensive Blood pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT II)显示文摘 | Qureshi AI Palesch YY Martin R | | J Vasc Interv Neurol0，7，2： | 1 |
| 10 | Vertebroplasty: Clinical experience and follow-up results显示文摘 | MARTIN J B JEAN B SUGIN k et aI | 1999 | Bone1999，25，1： | 1 |
| 11 | Congenital malformations among 911 newborns conceived after infertility treatment with letrozole or clomiphene citrate 显示文摘 | Tulandi T Martin J AI - Fadhli R | 2006 | Fertil Steril2006，85，6： | 1 |
| 12 | Reporting stan- dards for percutaneous interventions in dialysis access 显示文摘 | Gray RJ Sacks D Martin LG et aI | 2003 | J Vasc Interv Radiol2003，14，： | 1 |
| 13 | GH-releasing peptide-2administration prevents liver inflammatory response inendotoxemia显示文摘 | Granado M Martin AI Menduina ML | 2008 | Am Physiological Soc2008，94，1： | 1 |
| 14 | Anti-inflammatory effect of the ghrelin agonist growth hormone-releasing peptide-2 ( GHRP-2 ) in arthritic rats显示文摘 | Granado M Priego T Martin AI | 2005 | Am J Physiol Endocrinol Metab2005，288，： | 1 |
| 15 | Localization of neuronal and glial glutamate transporters 显示文摘 | Rothstein JD Martin L Levey AI | 1994 | Neuron1994，13，3： | 1 |
| 16 | Changes in plasma lipids and markers o{ oxidative stress in normal pregnancy and pregnancies complicated by diabetes显示文摘 | Toescu V Nuttall SL Martin U et ai | 2004 | Clin Sci(Lond)2004，106，1： | 1 |
| 17 | Interpretation and implementation of intensive blood pressure reduction in acute cerebral hemorrhage trial (INTERACT II) 显示文摘 | Qureshi AI Palesch YY Martin R | 2014 | J Vase Interv Neurol2014，7，2： | 1 |
| 18 | Joint effects of C - reactive protein and glycated hemoglobin in predicting future cardio vascular events of patients with advanced athero sclerosis 显示文摘 | Martin S Markus E Jasmin A et ai | 2003 | Circulation2003，108，19： | 1 |
| 19 | Sirolimus (SRLmycin) for the treatment of steroid-refractory acute graft-versus-host disease显示文摘 | Benito AI Frulong T Martin PJ | 2001 | Transplantation2001，72，： | 1 |
| 20 | Location of neuronal and glial glutamate transporter显示文摘 | Rothstein JD Martin L Levey AI | 1994 | Neuron1994，13，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员