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| 1 | Galectin-3-centered paracrine network mediates cardiac inflammation and fibrosis upon β-adrenergic insult显示文摘Rapid over-activation of β-adrenergic receptors (β-AR) following acute stress initiates cardiac inflammation and injury by activating interleukin-18 (IL-18),however,the process of inflammation cascades has not been fully illustrated.The present study aimed to determine the mechanisms of cardiac inflammatory amplification following acute sympathetic activation.With bioinformatics analysis,galectin-3 was identified as a potential key downstream effector of β-AR and IL-18 activation.The serum level of galectin-3 was positively correlated with norepinephrine or IL-18 in patients with chest pain.In the heart of mice treated with β-AR agonist isoproterenol (ISO,5 mg kg^(-1)),galectin-3 expression was upregulated markedly later than IL-18 activation,and Nlrp3^(-/-)and Il18^(-/-)mice did not show ISO-induced galectin-3 upregulation.It was further revealed that cardiomyocyte-derived IL-18 induced galectin-3 expression in macrophages following ISO treatment.Moreover,galectin-3deficiency suppressed ISO-induced cardiac inflammation and fibrosis without blocking ISO-induced IL-18 increase.Treatment with a galectin-3 inhibitor,but not a β-blocker,one day after ISO treatment effectively attenuated cardiac inflammation and injury.In conclusion,galectin-3 is upregulated to exaggerate cardiac inflammation and injury following acute β-AR activation,a galectin-3 inhibitor effectively blocks cardiac injury one day after β-AR insult. | Guomin Hu Jimin Wu Huijun Gu Xiangning Deng Wenli Xu Shan Feng Shuaixing Wang Yao Song Zhengda Pang Xiuling Deng Aleksandr E.Vendrov Nageswara R.Madamanchi Marschall S.Runge Xinyu Wang Youyi Zhang Han Xiao Erdan Dong | 2023 | Science China(Life Sciences)2023，66，5： | 3 |
| 2 | Intrahepatic cho- lestasis of pregnancy:Relationships between bile acid levels and fetal complication rates显示文摘 | Glantz A Marschall HU Mattsson LA | 2004 | Hepatology2004，40，3： | 1 |
| 3 | Gallstone disease 显示文摘 | Marschall HU Einarsson C | 2007 | J Intern Med2007，261，6： | 1 |
| 4 | Intrahepatic cholestasis of pregnancy: relationships between bile acid levels and fetal complication rate显示文摘 | Glantz A Marschall HU Mattsson LA | 2004 | Hepatol2004，40，2： | 1 |
| 5 | Intrahepatic cholestasis of pregnancy: Relationships between bile acid levels and fetal complication rates显示文摘 | Glantz A Marschall HU Mattsson LA | 2004 | Hepatology2004，40，2： | 1 |
| 6 | The geneticbackground of gallstone formation:an update显示文摘 | Marschall HU Katsika D Rudling M | 2010 | BiochemBiophys Res Commun2010，396，1： | 1 |
| 7 | Intrahepatic cholestasis of pregnancy:molecular pathogenesis,diagnosis and management显示文摘 | Lammeot F Marschall HU Glantz A | 2003 | J Hepatol2003，33，： | 1 |
| 8 | Decreased 1,25-dihydroxy vitamin D levels in women with intrahepatic cholestasis of pregnancy显示文摘 | Wikstrm Shemer E Marschall HU | 2010 | Acta Obstet Gynecol Scand2010，89，11： | 1 |
| 9 | Intrahepatic cholestasis of pregnancy: Relationships between bile acid levels and fetal complication rates显示文摘 | Glantz A Marschall HU Mattsson LA | 2004 | Hepatology2004，40，2： | 1 |
| 10 | Intrahepatic cholestasis of pregnancy:molecular pathogenesis,diagnosis and management 显示文摘 | Lammert F Marschall HU Glantz A | 2000 | J Hepatol2000，33，6： | 1 |
| 11 | Intrahepatic cholestasis of pregnancy: molecular pathogenesis, diagnosis and management 显示文摘 | Lammert F Marschall HU Glantz A | 2000 | J Hepatol2000，33，6： | 1 |
| 12 | Bile acid changes after high-dose ursodeoxycholic acid treatment in primary sclerosing cholangitis:relation to disease progression显示文摘 | Sinakos E Marschall HU Kowdley KV | 2010 | Hepatology2010，52，1： | 1 |
| 13 | Intrahepatic cholestasis of pregnancy: molecular pathogenesis,diagnosis and management显示文摘 | Lammert F Marschall HU Glantz A | 2000 | J Hepatol2000，33，6： | 1 |
| 14 | Intrahepatic cholestasis of pregnancy:Relationships between bile acid levels and fetal complication rate显示文摘 | Glantz A Marschall HU Mattsson LA | | 0，，： | 1 |
| 15 | Intrahepatic cholestasis of pregnancy: relationships between bile acid levels and fetal complication rates 显示文摘 | Glantz A Marschall HU Mattsson LA | 2004 | Hepatology2004，40，2： | 1 |
| 16 | 'Sea blue histiocyte' syndrome显示文摘 | Marschall HU | 2000 | Dtsch Med Wochenschr2000，125，39： | 1 |
| 17 | Intrahepatic cholestasis of pregnancy : Relationships between bile acid levels and fetal complication rates 显示文摘 | Glantz A Marschall HU Mattsson LA | 2004 | Hepatology2004，40，2： | 1 |
| 18 | Intrahepatic cholestasis of pregnancy and associated adverse pregnancy and fetal outcomes : a 12 - year population- based cohort study 显示文摘 | WikstrOm Shemer E Marschall HU Ludvigsson JF | 2013 | BJOG2013，120，6： | 1 |
| 19 | Gallstone disease in Swedish twins is associated with the Gilbert variant of UGT1 A1 显示文摘 | Marschall HU Krawczyk M Grtmhage F | 2013 | Liver Int2013，33，6： | 1 |
| 20 | Intrahepatic cholestasis of preg- nancy: relationships between bile acid levels an fetal complication rate 显示文摘 | Glantz A Marschall HU Mattsson LA | 2004 | Hepatology2004，40，2： | 1 |
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