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| 1 | 神经生长因子增强小胶质细胞的神经保护作用显示文摘小胶质细胞是脑组织内的防御细胞,但在病理和生理条件下,调控小胶质细胞活化的因子并不十分清楚。本研究发现,神经生长因子(NGF)可以增强小胶质细胞的神经保护和抗炎功能。在体内和体外研究中都发现,小胶质细胞表达NGF受体。原代培养小胶质细胞,给予NGF处理,转录本分析结果显示,NGF对小胶质细胞的运动、吞噬和降解吞噬物的能力均产生影响。对功能的研究显示,NGF可增加小胶质细胞的膜运动能力和胞饮作用;在体研究显示,NGF可激活小胶质细胞释放向外整流电流,调节周围谷氨酸能神经元的神经传递。既往研究提示,小胶质细胞有清除脑内Aβ肽的功能,本研究观察了NGF对小胶质细胞吞噬能力的影响。结果显示,NGF可促进小胶质细胞通过Trk A途径清除Aβ,并加速其降解。此外,NGF还可减轻由Aβ导致的炎症激活。特异性激活小胶质细胞还可以减轻由Aβ导致的神经元树突损伤和长时程增强抑制。在对离体脑片的研究中,我们也发现NGF可以促进小胶质细胞吞噬Aβ。综上所述,本研究证实NGF可以促进小胶质细胞活化,活化的小胶质细胞通过抗炎作用减轻Aβ聚集,发挥神经保护作用。 | 唐颖馨 Rizzi C Tiberi A Giustizieri M Marrone MC Gobbo F Carucci NM Meli G Arisi I D'Onofrio M Marinelli S Capsoni S Cattaneo A | 2018 | 神经损伤与功能重建2018，13，2： | 2 |
| 2 | Supercritical extraction of clove bud essential oil: isolation and mathematical modeling显示文摘 | Marrone C | 1997 | Chemical Engineering Science1997，52，： | 1 |
| 3 | Effects of environment and progeny on biomass estimations of five hybrid poplar families grown at three contrasting sites across Europe 显示文摘 | Dillen S Marron N Bastien C | 2007 | Forest Ecology and Management2007，252，1： | 1 |
| 4 | Primary papillary carcinoma arising in a thyroglossal duet cyst显示文摘 | MARTIN-PEREZ E LARRANAGA E MARRON C | 1997 | Eur J Surg1997，163，： | 1 |
| 5 | Modeling and simulation of the supercritical CO2 extraction of vegetable oils显示文摘 | Reverchon E Marrone C | 2001 | Journal of supercritical Fluids2001，19，2： | 1 |
| 6 | A brief survey of bandwidth selection for density estimation显示文摘 | Jones M C Marron J S Sheather S J | 1996 | J Amer Statist Assoe1996，91，： | 1 |
| 7 | Hubble space telescope characterized by using phase retrieval algorithms显示文摘 | Fienup J R Marron J C Schulz T J | 1993 | J Opt Soc Am A1993，32，10： | 1 |
| 8 | A brief survey of bandwidth selection for density estimation显示文摘 | Jones M C Marron J S Sheather S J | | 0，，433： | 1 |
| 9 | Polarization insensitive fibre optic michelson interferometer显示文摘 | KERSEY A D MARRONE M J WASHINGTON D C | | 0，，06： | 1 |
| 10 | Factors associated with mobile phone ownership and potential use for rabies vaccination campaigns in southern Malawi显示文摘Background:Rabies is a fatal but preventable viral disease,which causes an estimated 59000 human deaths globally every year.The vast majority of human rabies cases are attributable to bites from infected domestic dogs and consequently control of rabies in the dog population through mass vaccination campaigns is considered the most effective method of eliminating the disease.Achieving the WHO target of 70%vaccination coverage has proven challenging in low-resource settings such as Sub Saharan Africa,and lack of public awareness about rabies vaccination campaigns is a major barrier to their success.In this study we surveyed communities in three districts in Southern Malawi to assess the extent of and socio-economic factors associated with mobile phone ownership and explore the attitudes of communities towards the use of short message service(SMS)to inform them of upcoming rabies vaccination clinics.Methods:This study was carried out between 1 October–3 December 2018 during the post-vaccination assessment of the annual dog rabies campaign in Blantyre,Zomba and Chiradzulu districts,Malawi.1882 questionnaires were administered to households in 90 vaccination zones.The surveys gathered data on mobile phone ownership and use,and barriers to mobile phone access.A multivariable regression model was used to understand factors related to mobile phone ownership.Results:Most survey respondents owned or had use of a mobile phone,however there was evidence of an inequality of access,with higher education level,living in Blantyre district and being male positively associated with mobile phone ownership.The principal barrier to mobile phone ownership was the cost of the phone itself.Basic feature phones were most common and few owned smartphones.SMS was commonly used and the main reason for not using SMS was illiteracy.Attitudes to receiving SMS reminders about future rabies vaccination campaigns were positive.Conclusions:The study showed a majority of those surveyed have the use of a mobile phone and most mobile phone owners indicated they would like to receive SMS messages about future rabies vaccination campaigns.This study provides insight into the feasibility of distributing information about rabies vaccination campaigns using mobile phones in Malawi. | Orla Marron Gareth Thomas Jordana LBurdon Bailey Dagmar Mayer Paul OGrossman Frederic Lohr Andy DGibson Luke Gamble Patrick Chikungwa Julius Chulu Ian GHandel Barend Mde C Bronsvoort Richard JMellanby Stella Mazeri | 2020 | Infectious Diseases of Poverty2020，9，3： | 1 |
| 11 | Comparison of two bandwidth selectors with dependent errors显示文摘 | Chu C K Marron J S | 1991 | Annals of Statistics1991，19，： | 1 |
| 12 | Hubble space telescope characterized by using phase-retrieval algorithms显示文摘 | Fienup J R Marron J C Schulz T J | 1993 | Appl Opt1993，32，10： | 1 |
| 13 | Seasonal and daily time course of the 13C composition in soil CO2 efflux recorded with a tunable diode laser spectrophotometer ( TDLS ) 显示文摘 | Marron N Plain C Longdoz B | 2009 | Plant Soil2009，318，12： | 1 |
| 14 | Genetic polymorphism in the human UGT1 A6 (planar phenol) UDP-glucuronosyl -transferase: pharmacological implications 显示文摘 | Ciotti M Marrone A Potter C Owens IS | 1997 | Pharmacogenetics1997，7，6： | 1 |
| 15 | Chemical relaxation with preferential dissociation from exited vibrational levels显示文摘 | Marrone P V Treater C E | 1963 | Phys Fluids1963，6，9： | 1 |
| 16 | Benefits of preserving residual renal function in peritoneal dialysis显示文摘 | Marron B Remon C Perez-Fontan M | 2008 | Kidney Int Suppl2008，，108： | 1 |
| 17 | Local and sys- temic cellular and antibody immune responses of cattle to in- fectious bovine rhinotracheitis virus vaccines administered in- tranasally or intramuscularly 显示文摘 | GERBER J D MARRON A E KUCERA C J | 1978 | Am J Vet Res1978，39，5： | 1 |
| 18 | Fimbrial adhesins:similarities and variations in structure and biogenesis显示文摘 | Smyth C J Marron M B Twohig J M | 1996 | FEMS Immunol Med Microbiol1996，16，2： | 1 |
| 19 | Almond oil ex traction by super critical CO2: experiments and modeling显示文摘 | MARRONE C POLETTO M REVERCHON E | 1998 | Chemical Engineering Science1998，53，21： | 1 |
| 20 | Benefits of preserving residual renal function in peritoneal dialysis 显示文摘 | Marron B Remon C Perez-Fontan M | 2008 | Kidney Int2008，73，8： | 1 |
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