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| 1 | Pancreaticoduodenectomy in patients ≥ 75 years of age:Are there any differences with other age ranges in oncological and surgical outcomes? Results from a tertiary referral center显示文摘AIM To compare surgical and oncological outcomes after pancreaticoduodenectomy(PD) in patients ≥ 75 years of age with two younger cohorts of patients. METHODS The prospectively maintained Institutional database of pancreatic resection was queried for patients aged ≥ 75 years(late elderly, LE) submitted to PD for any disease from January 2010 to June 2015. We compared clinical, demographic and pathological features and survival outcomes of LE patients with 2 exact matched cohorts of younger patients [≥ 40 to 64 years of age(adults, A) and ≥ 65 to 74 years of age(young elderly, YE)] submitted to PD, according to selected variables. RESULTS The final LE population, as well as the control groups, were made of 96 subjects. Up to 71% of patients was operated on for a periampullary malignancy and pancreatic cancer(PDAC) accounted for 79% of them. Intraoperative data(estimated blood loss and duration of surgery) did not differ among the groups. The overall complication rate was 65.6%, 61.5% and 58.3% for LE, YE and A patients, respectively, P = NS). Reoperation and cardiovascular complications were significantly more frequent in LE than in YE and A groups(P = 0.003 and P = 0.019, respectively). When considering either all malignancies and PDAC only, the three groups did not differ in survival. Considering all benign diseases, the estimated mean survival was 58 and 78 mo for ≥ and < 75 years of age(YE + A groups), respectively(P = 0.012). CONCLUSION Age is not a contraindication for PD. A careful selection of LE patients allows to obtain good surgical and oncological results. | Salvatore Paiella Matteo De Pastena Tommaso Pollini Giovanni Zancan Debora Ciprani Giulia De Marchi Luca Landoni Alessandro Esposito Luca Casetti Giuseppe Malleo Giovanni Marchegiani Massimiliano Tuveri Enrico Marrano Laura Maggino Erica Secchettin Deborah Bonamini Claudio Bassi Roberto Salvia | 2017 | World Journal of Gastroenterology2017，23，17： | 2 |
| 2 | Papillary renal cell carcinoma within a renal oncocyloma:case report of an incidental finding of a tumour with a tumour显示文摘 | Rowsell C Fleshner N Marrano P | | 0，，04： | 1 |
| 3 | Laparoscopic body--tail pancreatic resection for insulinoma显示文摘 | Minni F Marrano N Pasquali R | 2003 | Surg Endosc2003，17，1： | 1 |
| 4 | Papillary renal cell carcinoma within a renal oncocytoma:case report of an incidental finding of a tumor within a tumor显示文摘 | Rowsell C Fleshner N Marrano P | 2007 | J Clin Pathol2007，60，4： | 1 |
| 5 | High--resolution mapping of am- plifications and deletions in pecliatric osteosarcoma by use of CGH analysis of cDNA microarrays显示文摘 | SquireJA PeiJ Marrano P | 2003 | Genes chromosomes cancer2003，38，3： | 1 |
| 6 | Resolution of genotypic hetero-geneity in prostate tumors using polymerase chain reaction and comparative genomic hybridization on microdissected carcinoma and prostatic intraepithelial neoplasia foci 显示文摘 | Beheshti B Vukovic B Marrano P | 2002 | Cancer Genet Cytogenet2002，137，1： | 1 |
| 7 | What happened to the knowledge economy? ICT, intangible investment, and Britain's productivity record revisited 显示文摘 | Marrano M G Haskel J Wallis G | 2009 | Review of Income and Wealth2009，55，3： | 1 |
| 8 | Pancreatic metastases: Observations of three cases and review of the literature显示文摘 | Francesco Minni Riccardo Casadei Barbara Perenze Vincenzo Maria Greco Nicola Marrano Alessandra Margiotta Domenico Marrano | 2004 | Pancreatology2004，，： | 1 |
| 9 | Papillary renal cell carcinoma within a renal oncocytoma:case report of an incidental finding of a tumour within a tumour 显示文摘 | Rowsell C Fleshner N Marrano P | 2007 | J Clin Pathol2007，60，4： | 1 |
| 10 | Resolution of genotypic heterogeneity in prostate tumors using polymerase chain reaction and comparative genomic hybridization on microdissected carcinoma and prostatic intraepithelial neoplasia foci显示文摘 | Beheshti B Vukovic B Marrano P | 2002 | Cancer Genet Cytogenet2002，137，1： | 1 |
| 11 | Genomic signatures of different adaptations to environmental stimuli between wild and cultivated Vitis vinifera L显示文摘The application of population genetic methods in combination with gene mapping strategies can help to identify genes and mutations selected during the evolution from wild plants to crops and to explore the considerable genetic variation still maintained in natural populations.We genotyped a grapevine germplasm collection of 44 wild(Vitis vinifera subsp.sylvestris)and 48 cultivated(V.vinifera subsp.sativa)accessions at 54 K single-nucleotide polymorphisms(SNPs)to perform a whole-genome comparison of the main population genetic statistics.The analysis of Wright Fixation Index(FST)along the whole genome allowed us to identify several putative“signatures of selection”spanning over two thousand SNPs significantly differentiated between sativa and sylvestris.Many of these genomic regions included genes involved in the adaptation to environmental changes.An overall reduction of nucleotide diversity was observed across the whole genome within sylvestris,supporting a small effective population size of the wild grapevine.Tajima’s D resulted positive in both wild and cultivated subgroups,which may indicate an ongoing balancing selection.Association mapping for six domestication-related traits was performed in combination with population genetics,providing further evidence of different perception and response to environmental stresses between sativa and sylvestris. | Annarita Marrano Diego Micheletti Silvia Lorenzi David Neale M.Stella Grando | 2018 | Horticulture Research2018，5，1： | 1 |
| 12 | Chromosomal localization of DNA amplifications in neuroblastoma tumors using cDNA microarray comparative genomic hybridization显示文摘 | Beheshti B Braude I Marrano P | 2003 | Neoplasia2003，5，1： | 1 |
| 13 | Papillary renal cell carcinoma with in a renal oncocytoma:case report of an incidental finding of a tumour within a tumour 显示文摘 | Rowsell C Fleshner N Marrano P | 2007 | J Clin Pathol2007，60，4： | 1 |
| 14 | Laparoscopic body-tail pancreatic resection for insulinoma 显示文摘 | Minni F Marrano N Pasquali R | 2003 | Surg Endosc2003，17，1： | 1 |
| 15 | Papillary renal cell carcinoma within a renal oncocytoma : case report of an incidental finding of a tumour within a tumour显示文摘 | Rowsell C Fleshner N Marrano P | 2007 | J Clin Pathol2007，60，4： | 1 |
| 16 | Chromosomal localization of DNA amplification in neuroblastoma tumors using cDNA microarray comparative genomic hybridization显示文摘 | Beheshti B Braude I Marrano P | 2003 | Neoplasia2003，5，： | 1 |
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