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| 1 | 高纤维膳食和补充乙酸盐改变肠道菌群,预防醋酸脱氧皮质酮-盐型高血压小鼠高血压和心力衰竭的发展显示文摘水果和蔬菜的膳食摄入与高血压的发生率较低有关,但所涉及的机制尚未阐明。该研究评估了高纤维膳食和短链脂肪酸(short-chain fatty acid,SCFA)(乙酸盐)对肠道微生物群和预防心血管病的影响。方法:用盐皮质激素诱发小鼠高血压模型,观测正常喂食组、高纤维喂食组和补充乙酸盐组的肠道微生物、心脏结构/功能和血压水平。 | 刘莉 叶鹏 Marques FZ Nelson EM Chu PY Horlock D Fiedler A Ziemann M Tan JK Kuruppu S Rajapakse NW El-Osta A Mackay CR Kaye DM | 2016 | 中华高血压杂志2016，24，12： | 8 |
| 2 | Functional neuroimaging of minocycline' s effect in a patient with schizophrenia显示文摘 | Chaves C de Marque CR Wichert-Ana L | 2010 | Prog Neuropsychopharmacol Biol Psychiatry2010，34，： | 1 |
| 3 | Contribution for the derivation of a soil screening value(SSV)for uranium,using a natural reference soil显示文摘 | Caetano AL Marques CR Gavina A | 2014 | PLo S One2014，9，10： | 1 |
| 4 | Local adverse effects associated with the use of inhaled corticosteroids in patients with moderate or severe asthma显示文摘 | Pinto CR Almeida NR Marques TS | 2013 | J Bras Pneumol2013，39，4： | 1 |
| 5 | Factors associated with ca- rotid intima-media thickness and carotid plaques in type 2 diabetic pa- tients 显示文摘 | Cardoso CR Marques CE Leite NC | 2012 | J Hypertens2012，30，5： | 1 |
| 6 | Factors associated with carotid intima-media thickness and carotid plaques in type 2 diabetic patients显示文摘 | Cardoso CR Marques CE Leite NC | 2012 | J Hypertens2012，30，5： | 1 |
| 7 | Local adverse effects associated with the use of inhaled corticosteroids in patients with moderate or severe asthma显示文摘 | Pinto CR Ameida NR Marques TS | 2013 | J Bras Pneumol2013，39，4： | 1 |
| 8 | Eveluating Core Inflation Indicators显示文摘 | Marques CR Pedro Duarte Neves Luis Morais Sarment0 | 2000 | Economic Modelling2000，，20： | 1 |
| 9 | Glutamate-N-methyl-D-aspartate receptor modulation and minocycline for the treatment of patients with schizophrenia:an update显示文摘 | Chaves C Marque CR Trzesniak C | 2009 | Braz J Med Biol Res2009，42，： | 1 |
| 10 | Capsule enteroscopy is useful for the therapeutic management of Crohn's disease显示文摘AIM: To analyze therapeutic changes in Crohn's disease(CD) patients following video capsule endoscopy(VCE) and to assess the usefulness of Lewis score and the Patency Capsule.METHODS: Patency Capsule was performed in every patient that had indication for VCE, and those with negative patency did not undergo VCE. Patients with established CD that underwent VCE between January 2011 and February 2014 were selected for this study; those with suspected CD were excluded, independent of VCE results, since our purpose was to address differences in therapeutic regimen in CD patients before and after VCE. Patients with inconclusive VCE were also excluded. Patients had to be free of non-steroidal anti-inflammatories for at least 1 mo. Those patients who met these criteria were allocated into one of three groups: Staging group(asymptomatic CD patients that underwent VCE for staging of CD), Flare group(patients with active CD), or Post-op group(CD patients evaluated for post-operative recurrence). Lewis score was calculated for every VCE procedure. Statisticalanalysis was performed to address the impact of VCE findings on the therapeutic management of CD patients and to evaluate the utility of the Lewis score.RESULTS: From a total of 542 VCEs, 135 were performed in patients with CD. Patency capsule excluded nearly 25% of the patients who were supposed to undergo VCE. No videocapsule retention during VCE was reported. From these 135 patients, 29 were excluded because CD diagnosis was not established at the time of VCE. Therefore, a total of 106 patients were included in the final analysis. From these, the majority were in the Staging group(n = 73, 69%), and the remaining were in the Flare(n = 23, 22%) or Post-op(n = 10, 9%) group. Median time between diagnosis and VCE was 5.5 years. Overall, VCE determined changes in the treatment of 40% of patients: only 21% remained free of immunosuppressors after VCE compared to 44% before VCE(P < 0.001). The differences in therapy before and after VCE achieved statistical significance in the Staging and Flare groups. In addition, patients were significantly different when stratified regarding time since diagnosis to the date of VCE. A higher Lewis score was associated with therapeutic modifications(P < 0.0001); where a score higher than 1354 was related to 90% probability of changing therapy [area under the receiver operative characteristic(AUROC) 0.80(95%CI: 0.69-0.88)]. CONCLUSION: VCE significantly changed the therapeutic management of CD patients, even in those with long-term disease. Systematic use of Patency capsule allowed for no videocapsule retention. | Joao Santos-Antunes Hélder Cardoso Susana Lopes Margarida Marques Amadeu CR Nunes Guilherme Macedo | 2015 | World Journal of Gastroenterology2015，21，44： | 1 |
| 11 | Alzheimer disease : the quest to understand complexity显示文摘 | Marques SC Oliveira CR Outeiro TF t al | 2010 | J Alzheimers Dis2010，21，2： | 1 |
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