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| 1 | Deep sedation during gastrointestinal endoscopy: Propofol-fentanyl and midazolam-fentanyl regimens显示文摘AIM: To compare deep sedation with propofol-fentanyl and midazolam-fentanyl regimens during upper gastrointestinal endoscopy. METHODS: After obtaining approval of the research ethics committee and informed consent, 200 patients were evaluated and referred for upper gastrointestinal endoscopy. Patients were randomized to receive propofol-fentanyl or midazolam-fentanyl (n = 100/group).We assessed the level of sedation using the observer's assessment of alertness/sedation (OAA/S) score and bispectral index (BIS). We evaluated patient and physician satisfaction, as well as the recovery time and complication rates. The statistical analysis was performed using SPSS statistical software and included the MannWhitney test, χ 2 test, measurement of analysis of variance, and the κ statistic. RESULTS: The times to induction of sedation, recovery, and discharge were shorter in the propofolfentanyl group than the midazolam-fentanyl group. According to the OAA/S score, deep sedation events occurred in 25% of the propofol-fentanyl group and 11% of the midazolam-fentanyl group (P = 0.014). Additionally, deep sedation events occurred in 19% of the propofol-fentanyl group and 7% of the midazolamfentanyl group according to the BIS scale (P = 0.039). There was good concordance between the OAA/S score and BIS for both groups (κ = 0.71 and κ = 0.63, respectively). Oxygen supplementation was required in 42% of the propofol-fentanyl group and 26% of the midazolam-fentanyl group (P = 0.025). The mean time to recovery was 28.82 and 44.13 min in the propofolfentanyl and midazolam-fentanyl groups, respectively (P < 0.001). There were no severe complications in either group. Although patients were equally satisfied with both drug combinations, physicians were more satisfied with the propofol-fentanyl combination. CONCLUSION: Deep sedation occurred with propofolfentanyl and midazolam-fentanyl, but was more frequent in the former. Recovery was faster in the propofol-fentanyl group. | Marcos Eduardo Lera dos Santos Fauze Maluf-Filho Dalton Marques Chaves Sergio Eiji Matuguma Edson Ide Gustavo de Oliveira Luz Thiago Ferreira de Souza Fernanda C Simoes Pessorrusso Eduardo Guimares Hourneaux de Moura Paulo Sakai | 2013 | World Journal of Gastroenterology2013，19，22： | 16 |
| 2 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 3 | Triiodothyronine and breast cancer显示文摘The thyroid hormones(THs), triiodothyronine(T3) and thyroxine(T4), are essential for survival; they are involved in the processes of development, growth, and metabolism. In addition to hyperthyroidism or hypothyroidism, THs are involved in other diseases. The role of THs in the development and differentiation of mammary epithelium is well established; however, their specific role in the pathogenesis of breast cancer(BC) is controversial. Steroid hormones affect many human cancers and the abnormal responsiveness of the mammary epithelial cells to estradiol(E2) in particular is known to be an important cause for the development and progression of BC. The proliferative effect of T3 has been demonstrated in various types of cancer. In BC cell lines, T3 may foster the conditions for tumor proliferation and increase the effect of cell proliferation by E2; thus, T3 may play a role in the developmentand progression of BC. Studies show that T3 has effects similar to E2 in BC cell lines. Despite controversy regarding the relationship between thyroid disturbances and the incidence of BC, studies show that thyroid status may influence the development of tumor, proliferation and metastasis. | Maria Teresa De Sibio Miriane de Oliveira Fernanda Cristina Fontes Moretto Regiane Marques Castro Olimpio Sandro José Conde Aline Carbonera Luvizon Célia Regina Nogueira | 2014 | World Journal of Clinical Oncology2014，5，3： | 2 |
| 4 | Odd couple: The unexpected partnership of glucocorticoid hormones and cysteinyl-leukotrienes in the extrinsic regulation of murine bone-marrow eosinopoiesis显示文摘Granulopoiesis in murine bone-marrow is regulated by both intrinsic and extrinsic factors(including hormones, drugs, inflammatory mediators and cytokines). Eosinophils, a minor subpopulation of circulating leukocytes, which remains better understood in its contributions to tissue injury in allergic disease than in its presumably beneficial actions in host defense, provide a striking example of joint regulation of granulopoiesis within murine bone-marrow by all of these classes of extrinsic factors. We first described the upregulation of eosinopoiesis in bone-marrow of allergen-sensitized mice following airway allergen challenge. Over the last decade, we were able to show a critical role for endogenous glucocorticoid hormones and cytokines in mediating this phenomenon through modification of cytokine effects, thereby supporting a positive association between stress hormones and allergic reactions. We have further shown that cysteinylleukotrienes(Cys LT), a major proinflammatory class of lipid mediators, generated through the 5-lipoxygenase pathway, upregulate bone-marrow eosinopoiesis in vivo and in vitro. Cys LT mediate the positive effects of drugs(indomethacin and aspirin) and of proallergic cytokines(eotaxin/CCL11 and interleukin-13) on in vitro eosinopoiesis. While these actions of endogenous GC and Cys LT might seem unrelated and even antagonistic, we demonstrated a critical partnership of these mediators in vivo, shedding light on mechanisms linking stress to allergy: GC are required for Cys LT-mediated upregulation of bone-marrow eosinopoiesis in vivo, but also attenuate subsequent ex vivo responses to Cys LT. GC and Cys LT therefore work together to induce eosinophilia, but through subtle regulatory mechanisms also limit the magnitude of subsequent bone-marrow responses to allergen. | Pedro Xavier-Elsas Daniela Masid-de-Brito Bruno Marques Vieira Maria Ignez C Gaspar-Elsas | 2017 | World Journal of Experimental Medicine2017，7，1： | 2 |
| 5 | Development of Junction Elements from Study of the Bionics显示文摘The applications of bionic methodology developed by the Laboratory of Design and Material Selection as basis in the creation of junction elements were demonstrated. These elements favor the application of Ecodesign in reference to the effec-tiveness of product dismount aiming the reduction of ambient impact in all its phases of use. The creation,the development and the confection of new junction elements were described,and case studies of new products developed specifically with this purpose were presented. | Wilson Kindlein Junior Luis Henrique Alves Cndido André Canal Marques Sandra Souza dos Santos Maurício da Silva Viegas | 2007 | Journal of Bionic Engineering2007，4，1： | 2 |
| 6 | The 200th horizontal openhole gravel-packing operation in Campos Basin: a milestone in the history of petrohras completion practices in ultradeep waters显示文摘 | Marques L C C Paixao L C A Martions M O | 2007 | SPE1063642007，，： | 1 |
| 7 | Chemical composition of lipophilic extractives from jute (Corchorus capsularis)fibers used for manufacturing of high-quality paper pulps 显示文摘 | Rio Andrade J C Marques G Rodriguez Garcia M I | 2009 | Industrial Crops and Products2009，30，： | 1 |
| 8 | Biogenic amines in wines: influence of oenological factors显示文摘 | MARQUES A P LEITAO M C SAN ROMAO M V | 2008 | Food Chemistry2008，107，2： | 1 |
| 9 | Photosynthetic performance and pigment composition of leaves from two tropical species is determined by light quality 显示文摘 | Ramalho J C Marques N C Semedo J N | 2002 | Plant Biology2002，4，1： | 1 |
| 10 | Functional neuroimaging of minocycline' s effect in a patient with schizophrenia显示文摘 | Chaves C de Marque CR Wichert-Ana L | 2010 | Prog Neuropsychopharmacol Biol Psychiatry2010，34，： | 1 |
| 11 | In vitro response of the brown bullhead catfish( BB ) and rainbow trout( RTG-2 ) cell lines to benzo pyrene 显示文摘 | Araujo C S A Marques S A F Carrondo M J T | 2000 | Science of the Total Environment2000，247，2： | 1 |
| 12 | Complementary regulation of four eucalyptus CBF genes under various cold conditions显示文摘 | NAVARR() M MARQUE G AYAX C | 2009 | JournaloJ Ea''perimentalBotany2009，60，9： | 1 |
| 13 | European pen- nyroyal (Mentha pulegium) from Portugal:Chemical composi- tion of essential oil and antioxidant and antimicrobial proper- ties of extracts and essential oil显示文摘 | TEIXEIRA B MARQUES A RAMOS C | 2011 | Industrial Crops and Prod- ucts2011，36，： | 1 |
| 14 | Using middle level features for robust shape tracking 显示文摘 | NASCIMENTO J C ABRANTES A J MARQUES J S | 2003 | Pattern Recognition Letters2003，24，13： | 1 |
| 15 | Aqueous and solid complexes of iron( Ⅲ )with hyaluronic acid显示文摘 | Merce A L Marques Carrera L C ASantos Romanholi L K | 2002 | J Inorg Biochem2002，89，34： | 1 |
| 16 | Transcript profiling of Eucalyptus xylem genes during tension wood formation 显示文摘 | Paux E Carocha V Marques C | 2005 | New Phytologist2005，167，1： | 1 |
| 17 | Is agricultural policy promo- ting a new role for farmers? a case study显示文摘 | MARTINS M B MARQUES C | 2006 | Journal of Policy Modeling2006，，28： | 1 |
| 18 | Chsornosond characterization of the bonytongue Arapaima gigas ( Osteoglossiformes: Arapaimidae ) 显示文摘 | MARQUES D K VENERE P C JUNIOR P M G | 2006 | Neotropical Ichthyology2006，4，2： | 1 |
| 19 | Sur- factant distribution in waterborne acrylic films (1):Bulk inves-tigation显示文摘 | ARNOLD C THALMANN F MARQUES C | 2010 | The Journal of Physical Chemistry (B)2010，114，28： | 1 |
| 20 | Re-Os and Sm-Nd isotope and trace element constraints on the origin of the chromite deposit of the Ipueira-Medrado Sill, Bahia, Brazil 显示文摘 | Marques J C Ferreira Filho C F Carlson R W | 2003 | Journal of Petrology2003，44，4： | 1 |
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