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2篇 您的检索式:作者名="Mark T.Johnson"
    题名 作者 年代 出处 被引量
1聚合物发光二极管矩阵显示器显示文摘介绍聚合物发光二极管(poly_LED)矩阵显示器的发展历史、结构、原理及降低功耗的方法。最后介绍有源矩阵 poly_LED显示器的制作工艺和驱动方法。Mark T.Johnson Aad Sempel 2000现代显示2000,,2:1
2A phaseⅡprospective trial of photobiomodulation therapy in limiting oral mucositis in the treatment of locally advanced head and neck cancer patients显示文摘Objective:This study aimed to compare the historical incidence rate of severe oral mucositis(OM)in head and neck cancer patients undergoing definitive concurrent chemoradiation therapy(CRT)versus a prospective cohort of patients with locally advanced head and neck squamous cell carcinoma(HNSCC)treated with prophylactic photobiomodulation therapy(PBMT).Methods:This US-based,institutional,single-arm,phaseⅡprospective clinical trial was initiated in 50 patients(age≥18 years,Karnofsky Performance Scale Index>60,with locally advanced HNSCC(excluding oral cavity)receiving definitive or adjuvant radiation therapy(RT)with concurrent platinum-based chemotherapy(CT).PBMT was delivered three times per week throughout RT utilizing both an intraoral as well extraoral delivery system.Primary outcome measure was incidence of severe OM utilizing both the National Cancer Institute Common Toxicity Criteria,version 4.0(NCI-CTCAE)Grade≥3 and the World Health Organization Mucositis Grading Scale(WHO)Grade≥3 versus historical controls;secondary outcome measures included time to onset of severe OM following therapy initiation.Results:At baseline,all patients included in final analysis(N=47)had OM Grade 0.Average RT and CT dose was(66.3±5.1)Gy and(486.1±106.8)mg/m ^(2),respectively.Severe OM was observed in 11 of 47 patients(23%,confidence interval:12,38).OM toxicity grade trended upward during treatment,reaching a maximum at 7 weeks(WHO:1.8 vs.NCI-CTCAE:1.7).Subsequently,OM grade returned to baseline 3 months following completion of RT.The mean time to onset of severe OM was(35±12)days.The mean time to resolution of severe OM was(37±37)days.Conclusions:Compared to historical outcomes,PBMT aides in decreasing severe OM in patients with locally advanced HNSCC.PBMT represents a minimally invasive,prophylactic intervention to decrease OM as a major treatment-related side effect.Janielle K.-A.Taylor Leila J.Mady Khalil Baddour Uzoma K.Iheagwara Shuyan Zhai James P.Ohr Daniel P.Zandber Vikram C.Gorantla Robert L.Ferris Seungwon Kim Umamaheswar Duvvuri Mark W.Kubik Shaum Sridharan Jonas T.Johnson Karen D.Holeva Annette E.Quinn David A.Clump 2022World Journal of Otorhinolaryngology-Head and Neck Surgery2022,8,4:0
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