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| 1 | 帕博利珠单抗联合以铂类为基础的化疗治疗非小细胞肺癌合并稳定性脑转移患者的结局:KEYNOTE-021、-189和-407研究的汇总分析显示文摘背景与目的此项探索性分析回顾评价了晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的结局,旨在确定基线时合并脑转移是否会影响一线应用帕博利珠单抗联合化疗(pembrolizumab plus chemotherapy,PC)比对单用化疗的疗效。患者和方法对KEYNOTE-021队列G(非鳞癌)、KEYNOTE-189(非鳞癌)和KEYNOTE-407(鳞癌)三项研究晚期NSCLC患者的数据进行汇总分析。患者接受含铂两药化疗和/或35个周期帕博利珠单抗治疗(每3周200 mg)。所有研究均纳入了经治或初治的稳定性脑转移患者(KEYNOTE-189与KEYNOTE-407研究纳入初治脑转移患者)。经治的脑转移患者已处于病情稳定的状态≥2周(KEYNOTE-021队列G患者≥4周),无新发或脑转移病灶扩大的证据且入组前至少3天以上未使用激素。初治的无症状脑转移患者需定期接受脑部影像学检查。结果共纳入1298例患者,其中171例有基线脑转移,1127例无脑转移。两组的中位随访时间(范围)在数据截止时分别为10.9(0.1-35.1)个月和11.0(0.1-34.9)个月。合并脑转移和无脑转移患者的总生存期[0.48(95%CI:0.32-0.70)和0.63(95%CI:0.53-0.75)]和无进展生存期[0.44(95%CI:0.31-0.62)和0.55(95%CI:0.48-0.63)]的风险比(PC/化疗)相似。合并脑转移的患者中,PC组和单用化疗组患者的中位总生存期分别为18.8个月和7.6个月,中位无进展生存期分别为6.9个月和4.1个月。无论是否合并脑转移,PC组患者的客观缓解率都高于单用化疗组,且缓解持续时间有显著延长。合并脑转移的患者中,PC组与单用化疗组的治疗相关不良事件发生率分别为88.2%和82.8%;而无脑转移的患者中,两组治疗相关不良事件的发生率分别为94.5%和90.6%。结论无论是否合并脑转移,与单用化疗相比,帕博利珠单抗联合以铂类为基础的组织学特异性化疗可改善所有PD-L1亚组的临床结局,其中包括PD-L1肿瘤比例评分<1%的患者,并且在晚期NSCLC患者中安全性良好。该方案是晚期NSCLC初治患者的标准方案,并可用于合并稳定性脑转移的患者。 | 周清(翻译校对) Steven F Powell Delvys Rodríguez-Abreu Corey J Langer Ali Tafreshi Luis Paz-Ares Hans-Georg Kopp Jeronimo Rodríguez-Cid Dariusz M Kowalski Ying Cheng Takayasu Kurata Mark M Awad Jinaxin Lin Bin Zhao M Catherine Pietanza Bilal Piperdi Marina C Garassino | 2022 | 中国肺癌杂志2022，25，1： | 6 |
| 2 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 3 | Effects of very low dose daily,long-term Aspirin therapy on gastric,duodenal,and renal prostaglandin levels and on mucosal in jusy in healthy humans显示文摘 | Mark F | 1999 | Gastroenterology1999，117，1： | 1 |
| 4 | Optical time lens based on four wave mixing on a silicon chip显示文摘 | REZA S MARK A F AMY C T | 2008 | Optics Let- ters2008，33，10： | 1 |
| 5 | Angioplasty for Symptomatic Intracranial Stenosis : Clinical Outcome 显示文摘 | Marks M P Wojak J C Al-Ali F | 2006 | Stroke2006，37，： | 1 |
| 6 | The effects of land-uso history on soil properties and nutrient dynamics in northern hardwood forests of the ad- irondack mountains 显示文摘 | Larry E F Canham C D Marks P L | 2004 | Ecosystems2004，7，2： | 1 |
| 7 | Sensory descriptive texture analyses of cooked rice and its correlation to instrumental parameters using an extrusion cell显示文摘 | Meullenet J F C Gross J Marks B P | 1998 | Cereal Chemistry1998，75，5： | 1 |
| 8 | Improved deployment characteristics of a tether-connected munition system显示文摘 | Geoffrey F Mark C | 2001 | Journal of Guidance Control and Dynamics2001，24，3： | 1 |
| 9 | Face rec- ognition performance : role of demographic information 显示文摘 | Brenda F K Mark J B Joshua C K | 2012 | IEEE Transactions on Information Forensics and Security2012，7，6： | 1 |
| 10 | Efficient MAC in cognitive radio systems:a game-theoretic approach显示文摘 | Mark F Mario C Jean-Pierre H | | 0，，04： | 1 |
| 11 | Ocean surface wind speed measurements of the Special Sensor Microwave/Im- ager (SSM/I) 显示文摘 | Goodberlet Mark A Swift C F Wilkerson J C | 1990 | Geoscience and Remote Sensing IEEE Trans- actions on1990，28，5： | 1 |
| 12 | Thermal sensitivity of uncoupling protein expression in polar and temperate fish 显示文摘 | Mark F C Lucassen M Portner H O | 2006 | Comp Biochem Physiol(D)2006，1，： | 1 |
| 13 | Multidisciplinary prac- tical guidelines for gastrointestinal access for enteral nutrition and decompression from the Society of Interventional Radiology and American Gastroenterological Association ( AGA ) Institute, with endorsement by Canadian Interventional Radiological Association (CIRA) and Cardiovascular and Interventional Radiological Socie- ty of Europe(CIRSE) 显示文摘 | MAXIM I MARK H D JOHN C F | 2011 | J Vasc Interv Radiol2011，22，8： | 1 |
| 14 | Criteria used for protection of natural areas in Sweden 1909~1986显示文摘 | Got Mark F Nilsson C | 1992 | Conservation Biology1992，6，2： | 1 |
| 15 | Phylogenetically distinct cellulose synthase genessupport secondary wall thickening in Arabidopsis shoot trichomes and cotton fiber显示文摘 | Betancur L Singh B Rapp R A Wendel J F Marks M D Roberts A W Haigler C H | | 0，，02： | 1 |
| 16 | Evaluation of a functional position for lateral radiograph acquisition in adolescent idiopathic scoliosis显示文摘 | Faro F D Marks M C Pawelek J | 2004 | Spine2004，29，20： | 1 |
| 17 | Inhibitors of hepatitis C virus NS3·4A protease. Part 3: P 2 proline variants显示文摘 | Robert B Perni Luc J Farmer Kevin M Cottrell John J Court Lawrence F Courtney David D Deininger Cynthia A Gates Scott L Harbeson Joseph L Kim Chao Lin Kai Lin Yu-Ping Luong John P Maxwell Mark A Murcko Janos Pitlik B.Govinda Rao Wayne C Schairer Roger D T | 2004 | Bioorganic & Medicinal Chemistry Letters2004，，8： | 1 |
| 18 | Bio显示文摘 | Steven H D H Mark A M James F C | 2010 | Annual Review of Marine Science2010，2，1： | 1 |
| 19 | Prognostic significance of lymph node metastasis found during pulmonary metastasectomy for extrapulmonary carcinoma显示文摘 | Sina Ercan Francis C Nichols Victor F Trastek Claude Deschamps Mark S Allen Daniel L Miller Cathy D Schleck Peter C Pairolero | 2004 | The Annals of Thoracic Surgery2004，，5： | 1 |
| 20 | Part Ⅱ: The GBVTD-simplex center finding algorithm 显示文摘 | Lee W C Marks F D Tropical cyclone kinematic structure retrieved from single-Doppler radar observations | 2000 | Monthly Weather Review2000，128，6： | 1 |
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