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| 1 | Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis显示文摘The pool of microbes inhabiting our body is known as 'microbiota' and their collective genomes as 'microbiome'. The colon is the most densely populated organ in the human body, although other parts, such as the skin, vaginal mucosa, or respiratory tract, also harbour specific microbiota. This microbial community regulates some important metabolic and physiological functions of the host, and drives the maturation of the immune system in early life, contributing to its homeostasis during life. Alterations of the intestinal microbiota can occur by changes in composition(dysbiosis), function, or microbiota-host interactions and they can be directly correlated with several diseases. The only disease in which a clear causal role of a dysbiotic microbiota has been demonstrated is the case of Clostridium difficile infections. Nonetheless, alterations in composition and function of the microbiota have been associated with several gastrointestinal diseases(inflammatory bowel disease, colorectal cancer, or irritable bowel syndrome), as well as extra-intestinal pathologies, such as those affecting the liver, or the respiratory tract(e.g., allergy, bronchial asthma, and cystic fibrosis), among others. Species of Bifidobacterium genus are the normal inhabitants of a healthy human gut and alterations in number and composition of their populations is one of the most frequent features present in these diseases. The use of probiotics, including bifidobacteria strains, in preventive medicine to maintain a healthy intestinal function is well documented. Probiotics are also proposed as therapeutic agents for gastrointestinal disorders and other pathologies. The World Gastroenterology Organization recently published potential clinical applications for several probiotic formulations, in which species of lactobacilli are predominant. This review is focused on probiotic preparations containing Bifidobacterium strains, alone or in combination with other bacteria, which have been tested in human clinical studies. In spite of extensive literature on and research into this topic, the degree of scientific evidence of the effectiveness of probiotics is still insufficient in most cases. More effort need to be made to design and conduct accurate human studies demonstrating the efficacy of probiotics in the prevention, alleviation, or treatment of different pathologies. | Rafael Tojo Adolfo Suárez Marta G Clemente Clara G de los Reyes-Gavilán Abelardo Margolles Miguel Gueimonde Patricia Ruas-Madiedo | 2014 | World Journal of Gastroenterology2014，20，41： | 33 |
| 2 | The male menopause and mood:teslosteron decline and depression in the aging male - is the real link 显示文摘 | Margoles H C | 2000 | J Geriatr Psychiztry Neuro12000，13，3： | 1 |
| 3 | Structure-function analysis of multidrug transporters in Lactococcus lactis显示文摘 | van Veen H W Putman M Margolles A | 1999 | Biochim Biophys Acta1999，1461，2： | 1 |
| 4 | The FIF0 -ATPase of Bifidobacterium animalis is involved in bile tolerance显示文摘 | Borja Senchez Clara G de los Reyes-Gavilen Abelardo Margolles | 2006 | Environmental Microbiology2006，8，10： | 1 |
| 5 | A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes 显示文摘 | Margolls R Spalde RF | 2009 | Am J OphOzcdmol2009，147，6： | 1 |
| 6 | Molecular assessment of erythromycin and tetracycline resistance genes in lactic acid bacteria and bifidobacteria and their relation to the phenotypic resistance 显示文摘 | Van Hoek AHAM Margolles A Domig K J et ol | 2008 | Int J Probiotics Prebiotics2008，3，1： | 1 |
| 7 | Modelling and Confort of Large Hexible frame Vehicles Using Bond Graphs显示文摘 | David Edeal | 2003 | SAE paper 8924882003，24，： | 1 |
| 8 | Efficient expression and secretion of recombinant alpha amylase in Pichia pastoris using two different signal sequences显示文摘 | Paifer E Margolles E Cremata J | 1994 | Yeast1994，10，： | 1 |
| 9 | Generalized sythesis of periodic surfactant/ inorganic composite materials 显示文摘 | Huo Q S Margol Ese D I CI Esla U | 1994 | Nature1994，368，： | 1 |
| 10 | Distinct Bifidobacte- rium strains drive different immune responses in vitro 显示文摘 | Lopez P Gueimonde M Margolles A | 2010 | Int J Food Micmbiol2010，138，12： | 1 |
| 11 | Video-assisted thomcic surgery lobectomy for stage? Lung cancer显示文摘 | Gharagozloo F Tempesta B MargolisM | 2003 | Ann Thorac Surg2003，76，4： | 1 |
| 12 | Infection controlknowledge, attitudes, and practices among healthcare workers inAddis Ababa, Ethiopia 显示文摘 | Tenna A Stenehjem EA Margoles L | 2013 | Infect Control Hosp Epidemiol2013，34，12： | 1 |
| 13 | Competitive exclusion of enteropathogens from human intestinal mucus by Bifidobacterium strains with acquired resistance to bile--a preliminary study 显示文摘 | Gueimonde M Margolles A de los Reyes- Gavilan CG | 2007 | International Journal of Food Microbiology2007，113，2： | 1 |
| 14 | Deconjugation and Bile Salts Hydrolase Activity by Bifidobaeterium Strains with Acquired Resistance to Bile 显示文摘 | NORIEGA L CUEVAS I MARGOLLES A | 2006 | Int Dairy J2006，，16： | 1 |
| 15 | Generalized synthesis of periodicsurfctant/inorganic composite materials显示文摘 | Huo QS Margoles D I Ciesla U | 1994 | Nature1994，378，： | 1 |
| 16 | Complement componet C1q modulates the phagocytosis of Abeta by microglia显示文摘 | Webster SD Yang AJ Margol L | 2000 | Exp Neurol2000，161，1： | 1 |
| 17 | The F1F0-AT- Pase of Bifidobacterium animalis is involved in bile tolerance 显示文摘 | Sanchez B De Los Reyes-Gavilan C G Margolles A | 2006 | Environmental microbiology2006，8，10： | 1 |
| 18 | Characteri sation of a Bifidobacterium strainwith acquired resistance to cholate-A preliminary study 显示文摘 | Margolles A Carcia L Sanchez B | 2003 | Int J Food Microbiol2003，2，82： | 1 |
| 19 | Ability of Bifidobacterium strains with acquired resistance to bile to adhere to human intestinal mucus显示文摘 | Miguel Gueimonde Luis Noriega Abelardo Margolles | | 0，，： | 1 |
| 20 | Some chemical and bacteriological characteristics of regional cheeses from Asturias, Spain显示文摘 | Margolles A A Rodriguez C G de los Reyes-Gavilan | 1996 | J of Food Prot1996，59，： | 1 |
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