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| 1 | Is liver biopsy still needed in children with chronic viral hepatitis?显示文摘Liver biopsy is a standard method used for obtaining liver tissue for histopathological evaluation. Since reliable serological and virological tests are currently available, liver biopsy is no longer needed for the etiological diagnosis of chronic hepatitis B and C. However, liver histology remains the gold standard as a prognostic tool, providing information about the liver disease progression(grading of necroinflammatory activity and staging of fibrosis) and serving clinicians in the management and therapeutic decisions. In general, histopathological evaluation is indicated before starting the antiviral treatment. Main limitations of the liver biopsy include its invasive and painful procedure, sampling errors and the inter- and intra-observer variability. In addition, indications for the liver biopsy in pediatric patients with chronic viral hepatitis were questioned recently, and efforts have been made toward the development of non-invasive methods as an alternative to the liver biopsy. The most commonly used methods are novel imaging studies(elastography) and combinations of biomarkers. However, to date, none of these tests was validated in children with chronic viral hepatitis. In this review, we present the current status of the liver biopsy in the management of chronic viral hepatitis B and C in pediatric population, including specific indications, complications, contraindications, problems, limitations, and alternative non-invasive methods. | Maria Pokorska-?piewak Barbara Kowalik-Miko?ajewska Ma?gorzata Aniszewska Magdalena Pluta Magdalena Marczyńska | 2015 | World Journal of Gastroenterology2015，21，42： | 5 |
| 2 | Production of hexanal from hydroly zed sunflower oil by lipoxygenase and hydroperoxide lyase enzymes显示文摘 | Marczy J S Nemeth A S Samu Z | 2002 | Bio technology Letters2002，24，20： | 1 |
| 3 | Biocatalytlc production of 2 ( E)-hexenal from hydrolysed linseed oil 显示文摘 | Agnes Sz Nemeth Judit Sz Marczy Zsuzsa Samu | 2004 | Enzyme and Microbial Technology2004，334，： | 1 |
| 4 | Different apoptesis ratios and gene expressions in two human cell lines after sevoflurane anaesthesia 显示文摘 | Kvolik S Dobrosevic B Marczi S | 2009 | Acta Anaesthesiol Scand2009，53，9： | 1 |
| 5 | Production of hexanal from hydrolyzed sunflower oil by lipoxygenase and hydroperoxide lyase enzymes 显示文摘 | Marczy J S Nemeth A S Samu Z | 2002 | Biotechnology Letters2002，24，20： | 1 |
| 6 | Production of hexanal from hydrolyzed sunflower oil by lipoxygenaseand hydroperoxide lyase enzymes 显示文摘 | MARCZY J S NEMETH A S SAMU Z | 2002 | Biotechnology Let- ters2002，24，： | 1 |
| 7 | Production of hexanal from hydrolyzed sunflower oil by lipoxygenase and hydroperoxide lyase enzymes 显示文摘 | Marczy Judit Sz Nemeth agnes Sz Samu Zsuzsanna | 2002 | Biotechnology Letters2002，24，： | 1 |
| 8 | Evidence for the role of nitric oxide in the circulation of the dental pulp显示文摘 | Lohilai Z Balla I Marczis Z | 1995 | J Dent Res1995，74，12： | 1 |
| 9 | The influence of cell growth media on the stability and antitumour activity of me- thionine enkephalin 显示文摘 | Glavas-Obrovac L Jakas A Marczi S | 2005 | J Pept Sci2005，11，8： | 1 |
| 10 | Comparative study on the lipoxygenase activities of some soybean culti- vats显示文摘 | Marczy J S Simon M L Mozsik L | 1995 | Journal of Agricultural and Food Chemistry1995，43，： | 1 |
| 11 | Production of hexanal from hydrolyzed sunflower oil by lipoxygenase and hydroperox-ide lyase enzymes显示文摘 | Marczy JS Nemeth AS Samu Z | | 0，，： | 1 |
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