|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Five Colletotrichum species are responsible for mango anthracnose in northeastern Brazil显示文摘Colletotrichum species are the most important and widespread form of decay affecting mango fruit worldwide.In this study,Colletotrichum species associated with fruit anthracnose isolated from mango in northeastern Brazil were subject to molecular and morphological analyses.The partial sequences of the glyceraldehyde-3-phosphate dehydrogenase gene of 143 Colletotrichum isolates was amplified,as an initial measure of genetic diversity.A subset of 47 isolates,selected to represent the range of genetic diversity and geographic origin,were further sequenced using the partial actin,β-tubulin,calmodulin,glutamine synthetase genes and rDNA-ITS region.The multilocus sequence analysis,together with a critical examination of the phenotypic characters,revealed four previously described species(Colletotrichum asianum,Colletotrichum fructicola,Colletotrichum tropicale and Colletotrichum karstii)and one new species.The new species is introduced as Colletotrichum dianesei and formally described,illustrated and compared with similar taxa.Only C.asianum and C.karstii have previously been reported from mango,while the other species represent the first report associated with the mango fruits worldwide.All species are reported for the first time associated with the mango fruits in Brazil. | Nelson B.Lima Marcus Vinicius de A.Batista Marcos A.De Morais Jr Maria A.G.Barbosa Sami J.Michereff Kevin D.Hyde Marcos P.S.Câmara | 2013 | Fungal Diversity2013，，4： | 7 |
| 2 | Immunohistochemical expression of thymidylate synthase and prognosis in gastric cancer patients submitted to fluoropyrimidine-based chemotherapy显示文摘Objective: Adjuvant chemotherapy with 5-fluorouracil(5-FU) has been widely used in gastric cancer(GC)patients to prevent relapse after curative resection. 5-FU acts by inhibiting thymidylate synthase(TS), and high levels of TS correlate with resistance to treatment with fluoropyrimidines. The aim of this study was to evaluate the expression of TS in GC patients, and its relation with clinicopathological characteristics and prognosis in adjuvant chemotherapy with 5-FU.Methods: We retrospectively evaluated 285 patients who underwent D2-gastrectomy with curative intent. TS expression was determined by immunohistochemistry(IHC) in tumor cells by tissue microarray(TMA). TS level was evaluated according to the intensity and percentage of cells marked by a score system. Patients were divided in three groups according to their TS-score: negative, low and high.Results: TS expression was positive in 92.3% of GC. TS-high, TS-low and TS-negative were observed in46.3%, 46.0% and 7.7% of patients, respectively. High-TS GC were associated with older age(P=0.007), high neutrophil/lymphocyte ratio(P=0.048), well/moderately differentiated histology(P=0.001), intestinal Lauren type(P<0.001) and absence of perineural invasion(P=0.003). Among 285 patients, 133 stage Ⅱ/Ⅲ patients(46.7%)received chemotherapy with 5-FU. In survival analysis, TS-high was associated with worse disease-free survival(DFS) in stage Ⅲ GC patients who received 5-FU-based chemotherapy(P=0.007). Multivariate analysis revealed that total gastrectomy, poorly differentiated tumors and high TS-score were associated with worse DFS in stage Ⅲ GC patients.Conclusions: High TS-score in stage Ⅲ GC was associated with poor DFS in patients treated with fluoropyrimidine-based chemotherapy. | Marina Alessandra Pereira Marcus Fernando Kodama Pertille Ramos ANDre Roncon Dias Sheila Friedrich Faraj Cinthya dos Santos Cirqueira EvANDro Sobroza de Mello Bruno Zilberstein Venancio Avancini Ferreira Alves Ulysses Ribeiro Jr | 2018 | Chinese Journal of Cancer Research2018，30，5： | 3 |
| 3 | Gastric partitioning for the treatment of malignant gastric outlet obstruction显示文摘BACKGROUND Gastric outlet obstruction(GOO)is one of the main complications in stage IV gastric cancer patients.This condition is usually managed by gastrojejunostomy(GJ).However,gastric partitioning(GP)has been described as an alternative to overcoming possible drawbacks of GJ,such as delayed gastric emptying and tumor bleeding.AIM To compare the outcomes of patients who underwent GP and GJ for malignant GOO.METHODS We retrospectively analyzed 60 patients who underwent palliative gastric bypass for unresectable distal gastric cancer with GOO from 2009 to 2018.Baseline clinicopathological characteristics including age,nutritional status,body mass index,and performance status were evaluated.Obstructive symptoms were graded according to GOO score(GOOS).Surgical outcomes evaluated included duration of the procedure,surgical complications,mortality,and length of hospital stay.Acceptance of oral diet after the procedure,weight gain,and overall survival were the long-term outcomes evaluated.RESULTS GP was performed in 30 patients and conventional GJ in the other 30 patients.The mean follow-up was 9.2 mo.Forty-nine(81.6%)patients died during that period.All variables were similar between groups,with the exception of worse performance status in GP patients.The mean operative time was higher in the GP group(161.2 vs 85.2 min,P<0.001).There were no differences in postoperative complications and surgical mortality between groups.The median overall survival was 7 and 8.4 mo for the GP and GJ groups,respectively(P=0.610).The oral acceptance of soft solids(GOOS 2)and low residue or full diet(GOOS 3)were reached by 28(93.3%)GP patients and 22(75.9%)GJ patients(P=0.080).Multivariate analysis demonstrated that GOOS 2 and GOOS 3 were the main prognostic factors for survival(hazard ratio:8.90,95%confidence interval:3.38-23.43,P<0.001).CONCLUSION GP is a safe and effective procedure to treat GOO.Compared to GJ,it provides similar surgical outcomes with a trend to better solid diet acceptance by patients. | Marcus Fernando Kodama Pertille Ramos Leandro Cardoso Barchi Rodrigo Jose de Oliveira Marina Alessandra Pereira Donato Roberto Mucerino Ulysses Ribeiro Jr Bruno Zilberstein Ivan Cecconello | 2019 | World Journal of Gastrointestinal Oncology2019，11，12： | 2 |
| 4 | The incidence of myelitis after irradiation of the cervical spinal cord显示文摘 | Marcus RB Jr Million RR | | 0，，01： | 1 |
| 5 | Prognostic implications of tumor-infiltrating lymphocytes in association with programmed cell death ligand 1 expression in remnant gastric cancer显示文摘Objective:Remnant gastric cancer(RGC)is usually associated with a worse prognosis.As they are less common and very heterogeneous tumors,new prognostic and reliable determinants are required to predict patients’clinical course for RGC.This study aimed to investigate the tumor-infiltrating lymphocytes(TILs)and programmed cell death ligand 1(PD-L1)status as prognostic biomarkers in a cohort of patients with RGC to develop an immunerelated score.Methods:Patients with gastric cancer(GC)who underwent curative intent gastrectomy were retrospectively investigated.RGC resections with histological diagnosis of gastric adenocarcinoma were enrolled in the study.The risk score based on immune parameters was developed using binary logistic regression analysis.RGCs were divided into high-risk(HR),intermediate-risk(IR),and low-risk(LR)groups based on their immune score.The markers(CD3+,CD4+/CD8+T cells and PD-L1)were selected for their potential prognostic,therapeutic value,and evaluated by immunohistochemistry(IHC).Results:A total of 42 patients with RGC were enrolled in the study.The score based on immune parameters exhibited an accuracy of 79%[the area under the receiver operating characteristic curve(AUC)=0.79,95%confidence interval(95%CI),0.63-0.94,P=0.002],and the population was divided into 3 prognostic groups:10(23.8%)patients were classified as LR,15(35.7%)as IR,and 17(40.5%)as HR groups.There were no differences in clinicopathological and surgical characteristics between the three groups.In survival analysis,HR and IR groups had worse disease-free survival and overall survival rates compared to the LR group.In the multivariate analysis,lymph node metastasis and the immune score risk groups were independent factors related to worse survival.Conclusions:A scoring system with immune-related markers was able to distinguish prognostic groups of RGC associated with survival.Accordingly,tumor-infiltrating immune lymphocytes and PD-L1 status may serve as a potential prognostic biomarker for patients with RGC. | Marina Alessandra Pereira Marcus Fernando Kodama Pertille Ramos André Roncon Dias Leonardo Cardili Rafael Dyer Rodrigues de Moraes Renan Ribeiro E Ribeiro Venancio Avancini Ferreira Alves Bruno Zilberstein Evandro Sobroza de Mello Ulysses Ribeiro Jr | 2022 | Chinese Journal of Cancer Research2022，34，6： | 1 |
| 6 | Worldwide mortality in man and women aged 15-59 years from 1970 to 2010: a systematic analysis 显示文摘 | Rajaratnam JK Marcus JR Levin-Reetor A | 2010 | Lancet2010，375，9727： | 1 |
| 7 | Quantum hall effect in a gate-controlled P-N junction of grapheme显示文摘 | Williams JR DiCarlo L Marcus C M | 2007 | Science2007，317，5838： | 1 |
| 8 | Radiation therapy for giant cell tumors of bone显示文摘 | Feigenberg SJ Marcus Jr RB Zlotecki RA | 2003 | Clin Orthop2003，411，： | 1 |
| 9 | Baroreflex sensitivity and heart-rote variability in prediction of total cardiac mortality after myocardial infarction : ATRAMI ( Autonomic Tone and Reflexes After Myocardial infarction) Investigators 显示文摘 | La Rovere MT Bigger JT Jr Marcus FI | 1998 | Lancet1998，351，： | 1 |
| 10 | Current surgical practices in cleft care:unilateral cleft lip repair显示文摘 | Sitzman TJ Girotto JA Marcus JR | 2008 | Plast Reconstr Surg2008，121，5： | 1 |
| 11 | A dose- ranging study of the effect of transversus abdominis block on postoperative quality of recovery and analgesia ater outpa- tient laparoscopy显示文摘 | De Oliveira GS Jr Fitzgerald PC Marcus RJ | 2011 | Anesth Analg2011，113，5： | 1 |
| 12 | Analysis of oil pumping in a reciprocating compressor 显示文摘 | Antonio J Luckmann Marcus Vinieius C Alves Jader R Barbo- sa Jr | 2009 | Applied Thermal Engineering2009，29，： | 1 |
| 13 | Congenital epulis显示文摘 | Olson JL Marcus JR Zuker RM | 2005 | J CraniofacSurg2005，16，1： | 1 |
| 14 | Administration guidelines for radioimmunotherapy of non-Hodgkin's lymphoma with 90Y-labeled anti-CD20 monoclonal antibody显示文摘 | Wagner HN Jr Wiseman GA Marcus CS | 2002 | J Nucl Med2002，43，2： | 1 |
| 15 | Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction 显示文摘 | La Rovere MT Bigger JT Jr Marcus FI | 1998 | Lancet1998，351，9101： | 1 |
| 16 | Corrosion Fatigue: Chemistry, Mechanics and Microstructure 显示文摘 | Marcus H L Hackettle L H Jr Palmberg P W | 1972 | ASTM STP1972，499，： | 1 |
| 17 | Synthetic-aperture-radar imaging with a solid-state laser 显示文摘 | GREEN T J Jr MARCUS S COLELLA B D | 1995 | Appl Opt1995，34，30： | 1 |
| 18 | Baroreflex sensitivity and heart rate variability in prediction of total cardiac mortality after myocardial infarction 显示文摘 | LA ROVERE MT BIGGER JT JR MARCUS FI | 1998 | Lancet1998，351，9101： | 1 |
| 19 | Self-repotred oral dryness and HIV disease in a national sample of patients receiving medical care显示文摘 | Younai FS Marcus M Freed JR | | 0，，： | 1 |
| 20 | Baroreflex sensitivity and heart rate variability after myocardial infarction 显示文摘 | La Rovere M T Bigger J T Jr Marcus F I | 1998 | Lancet1998，351，9101： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员