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| 1 | 3D additive manufactured composite scaffolds with antibiotic-loaded lamellar fillers for bone infection prevention and tissue regeneration显示文摘Bone infections following open bone fracture or implant surgery remain a challenge in the orthopedics field.In order to avoid high doses of systemic drug administration,optimized local antibiotic release from scaffolds is required.3D additive manufactured(AM)scaffolds made with biodegradable polymers are ideal to support bone healing in non-union scenarios and can be given antimicrobial properties by the incorporation of antibiotics.In this study,ciprofloxacin and gentamicin intercalated in the interlamellar spaces of magnesium aluminum layered double hydroxides(MgAl)andα-zirconium phosphates(ZrP),respectively,are dispersed within a thermoplastic polymer by melt compounding and subsequently processed via high temperature melt extrusion AM(~190◦C)into 3D scaffolds.The inorganic fillers enable a sustained antibiotics release through the polymer matrix,controlled by antibiotics counterions exchange or pH conditions.Importantly,both antibiotics retain their functionality after the manufacturing process at high temperatures,as verified by their activity against both Gram+and Gram-bacterial strains.Moreover,scaffolds loaded with filler-antibiotic do not impair human mesenchymal stromal cells osteogenic differentiation,allowing matrix mineralization and the expression of relevant osteogenic markers.Overall,these results suggest the possibility of fabricating dual functionality 3D scaffolds via high temperature melt extrusion for bone regeneration and infection prevention. | María C´amara-Torres Stacy Duarte Ravi Sinha Ainhoa Egizabal Noelia´Alvarez Maria Bastianini Michele Sisani Paolo Scopece Marco Scatto Alessandro Bonetto Antonio Marcomini Alberto Sanchez Alessandro Patelli Carlos Mota Lorenzo Moroni | 2021 | Bioactive Materials2021，6，4： | 2 |
| 2 | Climate change influence on POPs distribution and fate: a case study 显示文摘 | Dalla Valle M Codato E Marcomini A | 2007 | Chemosphere2007，67，： | 1 |
| 3 | Risk based characterization of contaminated industrial site using multivariate and geostatistical tools显示文摘 | Carlon C Critto A Marcomini A | 2001 | Environmental Pollution2001，111，： | 1 |
| 4 | Risk based characterization of contaminated industrial site using multivariate and geostatistical tools 显示文摘 | Cation C Cfitto A Marcomini A | 2001 | Environmental Pollution2001，111，： | 1 |
| 5 | Improving ecological risk assessment by including bioavailability into species sensitivity distributions: An example for plants exposed to nickel in soil显示文摘 | SEMENZIN E TEMMINGHOFF E J M MARCOMINI A | 2007 | Environmental Pollution2007，148，： | 1 |
| 6 | Assessment of ecological risk from bioaccumulation of PCDD/Fs and dioxin-like PCBs in a coastal lagoon显示文摘 | MICHELETTI C CRITTO A MARCOMINI A | 2007 | Environment International2007，33，： | 1 |
| 7 | Pdsk based characterization of contaminated industrial site using multivariate and geostatistical tools 显示文摘 | Carlon C Critto A Marcomini A | 2001 | Environmental Pollution2001，111，： | 1 |
| 8 | Submitochondrial particle response to linear alkylbenzene sulfonates, nonylphenol polyethoxylates and their biodegradation deriva- tives显示文摘 | Argese E Marcomini A Miana P | 1994 | Environ Toxicol Chem1994，13，： | 1 |
| 9 | Risk based charac-terisation of contaminated industrial site using multivariate and geosta-tistical tools显示文摘 | CARLON C CRITTO A MARCOMINI A | 2001 | Environmental Pollution2001，111，3： | 1 |
| 10 | Simultaneous determination of linear alkylbenzene sulforttes, alkylphenol polyethoxylates, and nonylphenol by high-performance liquid chromatography显示文摘 | GIGER W | 1987 | Anal Chem1987，59，13： | 1 |
| 11 | Risk based characterization of contaminated industrial site using multivariate and geostatistical tools显示文摘 | CARLON C CRITTO A MARCOMINI A | 2001 | Environmental Pollution2001，111，3： | 1 |
| 12 | Simultaneous determination of linear alkylbenzone sulfomes,alkylphonol polyethoxylates,and nonyiphend by high-performance liquid chromatography显示文摘 | MARCOMINI A GIGER W | 1987 | Anal Chem1987，59，： | 1 |
| 13 | Persistent metabolites of alkylphenol polyethoxylates in the marine-environment显示文摘 | Marcomini A Pavoni B Sfriso A | | 0，，： | 1 |
| 14 | Macroalgae and phytoplankton Standing crops in the Central Venice Lagoon:Primary production and nutrient balance显示文摘 | SFRISO A PAVONI B MARCOMINI A | 1989 | Science of the Total Environment1989，80，23： | 1 |
| 15 | Reconstruction of historical trends of PCDD/Fs and PCBs in the Venice Lagoon,Italy显示文摘 | MATTEO D V MARCOMINI A JONES K C | 2005 | Environ Intern2005，31，7： | 1 |
| 16 | Risk Based Characterisation of Contaminated Industrial Site Using Multivariate and Geostatistical Tools显示文摘 | Carlon C Critto A Marcomini A | 2001 | Environmental Pollution2001，111，3： | 1 |
| 17 | Risk Based Characterisation of Contaminated Industrial Site Using Multivariate and Geostatistical Tools 显示文摘 | Carlon C Critto A Marcomini A al | 2001 | Environ Pollution2001，111，： | 1 |
| 18 | Risk based characterisation of contaminated Industrial site using multivariate and geostatistical tools显示文摘 | CARLON C CRITTO A MARCOMINI A | 2001 | Environmental Pollution2001，111，： | 1 |
| 19 | Gross primary production and nutrient behaviour in a shallow coastal environment 显示文摘 | SFRISO A MARCOMINI A | 1994 | Bioresource Technology1994，47，： | 1 |
| 20 | Regression models to predict water-soil heavy metals partition coefficients in risk assessment studies 显示文摘 | Carlon C Dalla Valle M Marcomini A | 2004 | Environmental Pollution2004，127，： | 1 |
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