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1篇 您的检索式：作者名="Marcel Kohn"

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		题名	作者	年代	出处	被引量
	1	POLIII-derived non-coding RNAs acting as scaffolds and decoys显示文摘A large variety of eukaryotic small structured POLIII-derived non-coding RNAs(ncRNAs)have been described in the past.However,for only few,e.g.7SL and H1/MRP families,cellular functions are well understood.For the vast majority of these transcripts,cellular functions remain unknown.Recent findings on the role ofY RNAs and other POLIII-derived ncRNAs suggest an evolutionarily conserved function of these ncRNAs in the assembly and function of ribonucleoprotein complexes(RNPs).These RNPs provide cellular‘machineries’,which are essential for guiding the fate and function of a variety of RNAs.In this review,we summarize current knowledge on the role of POLIII-derived ncRNAs in the assembly and function of RNPs.We propose that these ncRNAs serve as scaffolding factors that‘chaperone’RNA-binding proteins(RBPs)to form functional RNPs.In addition or associated with this role,some small ncRNAs act as molecular decoys impairing the RBP-guided control of RNA fate by competing with other RNA substrates.This suggests that POLIII-derived ncRNAs serve essential and conserved roles in the assembly of larger RNPs and thus the control of gene expression by indirectly guiding the fate of mRNAs and IncRNAs.	HendrikTauber Stefan Huttelmaier Marcel Kohn	2019	Journal of Molecular Cell Biology2019，11，10：	2

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