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| 1 | Microscopic colitis as a missed cause of chronic diarrhea显示文摘AIM: To determine the prevalence of increased intraepithelial lymphocytes, using immunohistochemistry in patients with normal colonoscopy and near normal biopsy. METHODS: We retrospectively reviewed all non-malignant colon mucosal biopsies between 2005 and 2007, reported as normal, chronic inflammation or melanosis coli in patients who were undergoing routine colonoscopy. Immunohistochemistry using CD3 was performed on all mucosal biopsies and an intraepithelial lymphocyte count (IEL) was determined. Cases with an IEL count of ≥ 20 IELs per 100 surface epithelial cells were correlated with demographic, clinical and follow-up data. A further subgroup was evaluated for lymphocytic colitis.RESULTS: Twenty (8.3%) of 241 cases revealed an IEL count ≥ 20. Six (2.5%) patients were identified as having lymphocytic colitis (P < 0.001), of whom, five were missed on initial evaluation (P = 0.01). Four of these five patients were labeled with diarrhea-predominant irritable bowel syndrome (IBS). On follow-up, three of the remaining 20 cases were diagnosed with malignancy (renal cell carcinoma and myelodysplastic syndrome) and one had an unknown primary tumor with multiple liver metastases. Two cases of collagenous colitis with an IEL count < 10 were included in this study. Increased IELs were not confined to patients with diarrhea as a primary presenting symptom, but were also present in patients with abdominal pain (n = 7), constipation (n = 3) and loss of weight (n = 1). CONCLUSION: Immunohistochemistry using CD3 is of value in identifying and quantifying IELs for the presence of microscopic colitis in patients with diarrheapredominant IBS. | Nooroudien Mohamed Monique Marais Juanita Bezuidenhout | 2011 | World Journal of Gastroenterology2011，17，15： | 2 |
| 2 | The natural historyof childhood intra-thoracic tuberculosis:a critical reviewof literature from the prechemotherapy era显示文摘 | Marais BJ Gie RP Schaaf HS | 2004 | Int J Tuberc Lung Dis2004，8，4： | 1 |
| 3 | Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C显示文摘 | Light Y Mason C | 1998 | Science1998，280，： | 1 |
| 4 | Interhospitaltransfer of pan-resistant Acinetobacter strains in Johannesburg,South Africa显示文摘 | MARAIS E DE JONG G FERRAZ V | 2004 | Am J Infect Control2004，32，5： | 1 |
| 5 | Oxygen consumption of a shallow water teleost the spotted gunter,Pomadasys commersonni显示文摘 | DU PREEZE H H MCLACHLAN A MARAIS J | 1986 | Comp Biochem Physiol1986，84，： | 1 |
| 6 | Influence of 2-methoxyestradiol on cell mor- phology and Cdc2 Kinase activity in WHC03 esophageal carcino- ma cells显示文摘 | Joubert A Marais S | 2007 | Biomed Res2007，28，1： | 1 |
| 7 | Comparative study of the molecular species of chloropropanediol diesters and triaeylg- lycerols in milk fat 显示文摘 | Kuksis A Marai L Myher J J | 1986 | Lipids1986，21，3： | 1 |
| 8 | Serological survey of Babesia bovis and Babesia bigemina in cattle in South Africa显示文摘 | Mohamad Alaa Terkawi Oriel M.M. Thekisoe Charles Katsande Abdalla A. Latif Ben J. Mans Olivier Matthee Nozipho Mkize Nomsa Mabogoane Frances Marais Naoaki Yokoyama Xuenan Xuan Ikuo Igarashi | 2011 | Veterinary Parasitology2011，，2： | 1 |
| 9 | Guilty as charged: B-RAF is a human oncogene显示文摘 | Garnett M J Marais R | 2004 | Cancer Cell2004，6，4： | 1 |
| 10 | The diffusive boundary layer of sediments:Oxygen microgradients over a microbial mat显示文摘 | JΦRGENSEN B B DES MARAIS D J | 1990 | Limnology and Oceanography1990，35，6： | 1 |
| 11 | Diversity of disease in childhood puhnonary tuberculosis 显示文摘 | Marais BJ Donald PR Gie RP | 2005 | Ann Trop Paediatr2005，25，2： | 1 |
| 12 | The agreement between cervical abnormalities identified by cytology and detection of highrisk types of human papillomavirus显示文摘 | Allan B R Marais D I Denny L | 2006 | S Afr Med J2006，96，11： | 1 |
| 13 | CREB activation and isclaemic preconditioning显示文摘 | Marais E Genade S Lochner | 2008 | Cardiovasc Drugs Ther2008，22，： | 1 |
| 14 | The role of signalingpathways in the development and treatment of hepatocellular carcinoma显示文摘 | WHITFAKER S MARAIS R ZHU AX | 2010 | Oncogene2010，29，36： | 1 |
| 15 | Tuberculous meningitis : a uniform case definition for use in clinical research显示文摘 | Marais S Thwaites G Schoeman JF | 2010 | Lancet Infect Dis2010，10，11： | 1 |
| 16 | Terpene Concentrations and Wine Quality of Vitis- Vinifera L Cv Gewurztraminer as Affected by grape Maturity and Cellar Practices 显示文摘 | Marais J | 1987 | Vitis1987，26，4： | 1 |
| 17 | The Association of Prolonged Breastfeeding and Allergic Disease in Poor urban Children显示文摘 | Obihara C C Marais B J Gie R P | 2005 | Eur Respir J2005，25，6： | 1 |
| 18 | WebL: A programming language for the web 显示文摘 | MARAIS H | 1998 | Computer Networks and ISDN Systems1998，30，17： | 1 |
| 19 | Mortality in young rabbits: areview 显示文摘 | Rashwan A A Marai I F M | 2000 | World Rabbit Science2000，8，3： | 1 |
| 20 | The role of signaling pathways in the development and treatment of hepatocellular carcinoma 显示文摘 | Whittaker S Marais R Zhu AX | 2010 | Onco- gene2010，29，36： | 1 |
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