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| 1 | COVID-19 vaccine development:milestones,lessons and prospects显示文摘With the constantly mutating of SARS-CoV-2 and the emergence of Variants of Concern(VOC),the implementation of vaccination is critically important.Existing SARS-CoV-2 vaccines mainly include inactivated,live attenuated,viral vector,protein subunit,RNA,DNA,and virus-like particle(VLP)vaccines.Viral vector vaccines,protein subunit vaccines,and mRNA vaccines may induce additional cellular or humoral immune regulations,including Th cell responses and germinal center responses,and form relevant memory cells,greatly improving their efficiency.However,some viral vector or mRNA vaccines may be associated with complications like thrombocytopenia and myocarditis,raising concerns about the safety of these COVID-19 vaccines.Here,we systemically assess the safety and efficacy of COVID-19 vaccines,including the possible complications and different effects on pregnant women,the elderly,people with immune diseases and acquired immunodeficiency syndrome(AIDS),transplant recipients,and cancer patients.Based on the current analysis,governments and relevant agencies are recommended to continue to advance the vaccine immunization process.Simultaneously,special attention should be paid to the health status of the vaccines,timely treatment of complications,vaccine development,and ensuring the lives and health of patients.In addition,available measures such as mix-and-match vaccination,developing new vaccines like nanoparticle vaccines,and optimizing immune adjuvant to improve vaccine safety and efficacy could be considered. | Maochen Li Han Wang Lili Tian Zehan Pang Qingkun Yang Tianqi Huang Junfen Fan Lihua Song Yigang Tong Huahao Fan | 2022 | Signal Transduction and Targeted Therapy2022，7，6： | 2 |
| 2 | SARS-CoV-2 variant Omicron:currently the most complete“escapee”from neutralization by antibodies and vaccines显示文摘On December 23,2021,five groups published their research results of clinical-approved monoclonal antibodies,convalescent serum,and vaccine serum against B.1.1.529(Omicron)on Nature.1–5 As a SARS-CoV-2 variant of concern(VOC),variant Omicron named by World Health Organization(WHO)with more mutations possesses the increased immune escape ability than all previous reported circulating variants,which has attracted extensive attention all over the world(Fig.1a). | Maochen Li Fuxing Lou Huahao Fan | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 1 |
| 3 | SARS-CoV-2 variants:a new challenge to convalescent serum and mRNA vaccine neutralization efficiency显示文摘The spike protein of SARS-CoV-2 is the target of antibodies in convalescent and vaccine sera,and 23 mutations in spike protein were reported in the variants B.1.1.7,B.1.351,and P.1(Fig.1a).Recently,several groups evaluated the effects of convalescent and mRNA vaccine sera on two major circulating SARS-CoV-2 variants B.1.1.7 and B.1.351(Fig.1b),1,2,3,4,5 which leads to concerns about the immune escape of these variants from the human acquired immunity stimulated by previous infections and mRNA vaccines. | Maochen Li Fuxing Lou Huahao Fan | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 0 |
| 4 | SARS-CoV-2 Variants of Concern Delta:a great challenge to prevention and control of COVID-19显示文摘Recently,three groups evaluated the effects of monoclonal antibodies,convalescent serum,and vaccines on Delta variant,^(1-3)which leads to concerns about the effectiveness of current vaccines to the upcoming SARS-CoV-2 variants.The World Health Organization(WHO)has designated SARS-CoV-2 variants Alpha(B.1.1.7),Beta(B.1.351),Gamma(P.1),and Delta(B.1.617.2)as Variants of Concern(VOC),among which Delta variant with remarkable transmission and immune escape ability has attracted great attentions. | Maochen Li Fuxing Lou Huahao Fan | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 0 |
| 5 | The monkeypox outbreak in 2022:adaptive evolution associated with APOBEC3 may account for显示文摘In a recent study published on Nature Medicine,Isidro,J et al.attempted to explore the potential causes of the recent monkeypox outbreak in 2022,1 which has been declared as a Public Health Emergency of International Concern(PHEIC).The genetic characterization study based on shotgun metagenomics suggested that the mutational bias(from GA to AA or TC to TT)in monkeypox genomes driven by apolipoprotein B mRNAediting catalytic polypeptide-like 3(APOBEC3)enzyme might account for the PHEIC. | Yangzhen Chen Maochen Li Huahao Fan | 2022 | Signal Transduction and Targeted Therapy2022，7，10： | 0 |
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