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| 1 | Helicobacter pylori and corpus gastric pathology are associated with lower serum ghrelin显示文摘AIM To evaluate the association of Helicobacter pylori(H. pylori), cag A genotype, and type of gastric pathology with ghrelin, leptin and nutritional status.METHODS Fasted dyspeptic adults(18-70 years) referred for an upper digestive endoscopy were enrolled in this crosssectional study. Height and weight were assessed for body mass index(BMI) calculation. A sociodemographic survey was administered and nutrient intake was evaluated with 24 h dietary recalls. Serum total ghrelin and leptin levels were analyzed by enzymelinked immunosorbent assay. 13 C-Urea Breath Test was performed and four gastric biopsies were obtained during endoscopy for histopathology and H. pylori DNA amplification and genotyping. Data analysis was performed using χ2, Mann-Whitney U, Kruskal-Wallis tests, Spearman's correlation and linear regression.RESULTS One hundred and sixty-three patients(40.8 ± 14.0 years), 98/65 females/males, were included. Overall, persistent H. pylori prevalence was 53.4%(95%CI: 45.7%-65.8%). Neither nutrient intake nor BMI differed significantly between H. pylori positive and negative groups. Serum ghrelin was significantly lower in infected patients [median 311.0 pg/m L(IQR 230.0-385.5)] than in uninfected ones [median 355.0 pg/m L(IQR 253.8-547.8)](P = 0.025), even after adjusting for BMI and gender(P = 0.03). Ghrelin levels tended to be lower in patients carrying cag A positive strains both in the antrum and the corpus; however, differences with those carrying cag A negative strains did not reach statistical significance(P = 0.50 and P = 0.49, respectively). In addition, the type and severity of gastric pathology in the corpus was associated with lower serum ghrelin(P = 0.04), independently of H.pylori status. Conversely, leptin levels did not differ significantly between infected and uninfected patients [median 1.84 ng/m L(0.80-4.85) vs 1.84 ng/m L(0.50-5.09),(P = 0.51)]. CONCLUSION H. pylori infection and severity of gastric corpus pathology are associated with lower serum ghrelin. Further studies could confirm a lower ghrelin prevalence in cag A-positive patients. | Paula Mantero Gonzalo Sebastián Matus Rodolfo Ernesto Corti Ana María Cabanne Gerardo Gabriel Zerbetto de Palma Liliana Marchesi Olid María Marta Piskorz Marcela Beatriz Zubillaga Mariana Andrea Janjetic Cinthia Gabriela Goldman | 2018 | World Journal of Gastroenterology2018，24，3： | 8 |
| 2 | Extensive use of peripheral angioplasty, particularly intiapopliteal, in the treatment of ischaemic diabetic foot ulcers: clinical results of a multicentric study of 221 consecutive diabetia subjects显示文摘 | Faglia E Mantero M Caminiti M | 2002 | J Intern Med2002，252，： | 1 |
| 3 | High cardiovascular risk in pa- tients with Cushing' s syndrome according to 1999 WHO/ISH guide- lines 显示文摘 | Mancini T Kola B Mantero F | 2004 | Clin Endocrinol ( Oxf)2004，61，6： | 1 |
| 4 | Adrenal incidentaloma:an overview of hormonal data from the National Italian Study Group显示文摘 | Mantero F Masini AM Opocher G | 1997 | Horm Res1997，47，46： | 1 |
| 5 | Partially supervised classification of remote sansing images through SVM-based probability density estimation 显示文摘 | MANTERO P MOSER G SERPICO S B | 2005 | IEEE Transactions on Geoscience and Remote Sensing2005，43，3： | 1 |
| 6 | Antibiotics as immunomodulant agents in COPD显示文摘 | Blasi F Mantero M Aliberti S | 2012 | Curr Opin Pharmacol2012，12，3： | 1 |
| 7 | Heterozygous D9OA- SOD1 mutation in a patient with facial onset sensory motor neu- ronopathy (FOSMN) syndrome: a bridge to amyotrophic lateral scle- rosis显示文摘 | Dalla BE Rigamonti A Mantero V | 2014 | J Neurol Neurosurg Psychiatry2014，85，： | 1 |
| 8 | Refraining English language education in Japan显示文摘 | Mantero Miguel & Iwai Yukko | 2005 | Asiam EFL Journal Volume 7 Issue 2 Retrieved July22005，2005，： | 1 |
| 9 | A comprehensive approach to adrenal incidentalomas显示文摘 | MANTERO F ALBIGER N | 2004 | Arq Bras Endocrinol Metabol2004，48，： | 1 |
| 10 | Aldosterone antagonists in hypertension and heart failure 显示文摘 | Mantero F Lucarejji G | 2000 | Ann Endocrinol2000，61，1： | 1 |
| 11 | McMansions: The Extent and Regulation of Super-Sized Houses显示文摘 | Nasar Jack L Jennifer S Evans-Cowley Vicente Mantero | 2007 | Journal of Urban Design2007，12，3： | 1 |
| 12 | Investigation protocol:adrenal enlargement显示文摘 | MANTERO F ARNALDI G | 1999 | Clin Endocrinol (Oxf)1999，50，： | 1 |
| 13 | Adrenal incidentalo- ma: an overview of hormonal data from the National Italian Study Group显示文摘 | Mantero F Masini AM Opocher G | 1997 | Horm Res1997，47，4： | 1 |
| 14 | polyethylenimine-based intravenous delivery of transgenes to mouse lung 显示文摘 | Goula D Benoist C Mantero S | 1998 | Gene Ther1998，5，9： | 1 |
| 15 | G-protein-coupled receptorsin aldosterone-producing adenomas: a potential cause ofhyperaldosteronism显示文摘 | Ye P Mariniello B Mantero F | 2007 | J Endocrinol2007，195，1： | 1 |
| 16 | Adrenal incidentaloma:an overview of hormonal data from the National Italian Study Group显示文摘 | Mantero F Masini AM Opocher G | | 0，，4： | 1 |
| 17 | The Dlx5 homeodomain gene is essential for olfactory development and connectivity in the mouse显示文摘 | Levi G Puche AC Mantero S | 2003 | Mol Cell Neurosci2003，22，4： | 1 |
| 18 | Spatiotemporal dynamics of gene expression of the Ednl-DIx5/6 pathway during development of the lower jaw显示文摘 | Vieux-Rochas M Mantero S Heude E | 2010 | Genesis2010，48，6： | 1 |
| 19 | Adrenal incidentaloma: an overview of hormonal data from the National Italian Study Group 显示文摘 | Mantero F Masini AM Opocher G | 1997 | Horm Res1997，47，46： | 1 |
| 20 | Left ventricular diastolic parameters in 288 normal subjects from 20 to 80 years old显示文摘 | Mantero A Gentile F Gualtlerotti C | 1995 | Eur Heart J1995，16，1： | 1 |
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