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| 1 | Dabigatran,rivaroxaban,and apixaban are superior to warfarin in Asian patients with non-valvular atrial fibrillation:An updated metaanalysis显示文摘BACKGROUND Most of the randomized clinical trials that led to the wide use of non-vitamin K antagonist oral anticoagulants for stroke prevention in patients with atrial fibrillation(AF)originated from western countries.AIM To systematically review and quantitatively synthesize the real-world data regarding the efficacy and safety of dabigatran,rivaroxaban,and apixaban compared to warfarin for stroke prevention in Asian patients with non-valvular AF.METHODS Medline,Cochrane,and ClinicalTrial.gov databases were reviewed.A randomeffect model meta-analysis was used and I-square was utilized to assess the heterogeneity.The primary outcome was ischemic stroke.The secondary outcomes were all-cause mortality,major bleeding,intracranial hemorrhage,and gastrointestinal bleeding.RESULTS Twelve studies from East Asia or Southeast Asia and 441450 patients were included.Dabigatran,rivaroxaban,and apixaban were associated with a significant reduction in the incidence of ischemic stroke[hazard ratio(HR)=0.78,95%confidence interval(CI):0.65-0.94;HR=0.79,95%CI:0.74-0.85,HR=0.70,95%CI:0.62-0.78;respectively],all-cause mortality(HR=0.68,95%CI:0.56-0.83;HR=0.66,95%CI:0.52-0.84;HR=0.66,95%CI:0.49-0.90;respectively),and major bleeding(HR=0.61,95%CI:0.54-0.69;HR=0.70,95%CI:0.54-0.90;HR=0.58,95%CI:0.43-0.78;respectively)compared to warfarin.CONCLUSION Dabigatran,rivaroxaban,and apixaban appear to be superior to warfarin in both efficacy and safety in Asians with non-valvular AF. | Wei-Jia Li Paraschos Archontakis-Barakakis Leonidas Palaiodimos Dimitrios Kalaitzoglou Lazaros Tzelves Apostolos Manolopoulos Yu-Chiang Wang Stefanos Giannopoulos Robert Faillace Damianos G Kokkinidis | 2021 | World Journal of Cardiology2021，13，4： | 3 |
| 2 | Generalized Hirsch h-index for disclosing latent facts in citation networks显示文摘 | Sidiropoulos A Katsaros D Manolopoulos Y | 2007 | Scientometrics2007，72，2： | 1 |
| 3 | Closest pair queries in spatial databases显示文摘 | Corral A Manolopoulos Y Theodoridis Y | 2000 | SIGMOD Record2000，29，2： | 1 |
| 4 | Cell adhesion molecules:role and clinical significance in cancer显示文摘 | Makrilia N Kollias A Manolopoulos L | 2009 | Concer Invest2009，27，10： | 1 |
| 5 | CO2 and KTP-532 laser cordectomy for bilateral vocal paralysis显示文摘 | Manolopoulos L Stavroulaki P Yiotakis J | 1999 | J Laryngol Otol1999，113，7： | 1 |
| 6 | Thrombin modulates vectorial secretion of extracellular matrix proteins in cultured endothelial cells显示文摘 | Papadimitriou E Manolopoulos VG Hayman GT | 1997 | Am J Physiol Cell Physiol1997，272，5： | 1 |
| 7 | A new perspective to automatically rank scientific conferences using digital libraries 显示文摘 | Sidiropoulos A Manolopoulos Y | 2005 | Information processing & management2005，41，2： | 1 |
| 8 | Fast nearest - neighbor query processing in moving-object databases显示文摘 | Raptopou lou K Papadopoulos A Manolopoulos Y | 2003 | GeoInformatica2003，7，2： | 1 |
| 9 | Processing distance join queries with constraints 显示文摘 | Papadopoulos A N Nanopoulos A Manolopoulos Y | 2006 | The Computer Journal2006，49，3： | 1 |
| 10 | Generalized hirsch h-index for disclosing latent facts in citation networks 显示文摘 | SIDIROPOULOS A KATSAROS D MANOLOPOULOS Y | 2007 | Scientometrics2007，72，2： | 1 |
| 11 | A uni- fied framework for providing recommendations in social tagging systems based on ternary semantic analysis 显示文摘 | Symeonidis P Nanopoulos A Manolopoulos Y | 2010 | Transactions on Knowledge and Data Engineering2010，22，： | 1 |
| 12 | Distributed processing of similarity queries显示文摘 | Papadopoulos A Manolopoulos Y | 2001 | Distributed and Parallel Databases2001，9，1： | 1 |
| 13 | p53, p21 and p27 protein expression in head and neck cancer and their prognostic value显示文摘 | Kapranos N Stathopoulos G P Manolopoulos L | 2001 | Anticancer Res2001，21，1： | 1 |
| 14 | Mining patterns from graph traversals显示文摘 | NANOPOULOS A MANOLOPOULOS Y | 2001 | Data and Knowledge Engineering2001，37，3： | 1 |
| 15 | Algorithms for processing k-closest-pair queries in spatial databases 显示文摘 | Corral A Manolopoulos Y Theodoridis Y | 2004 | Data and Knowledge Engineering2004，49，1： | 1 |
| 16 | Surgical correction of pinna malformations显示文摘 | Papacharalampous G Nikolopoulos TP Manolopoulos L | 2007 | J Plast Re- constr Aesthet Surg2007，60，6： | 1 |
| 17 | Inhibition of angiogenesis by blockers of volume-regulated anion channels显示文摘 | Manolopoulos VG Liekens S Koolwijk P | 2000 | GenPharmacol2000，34，： | 1 |
| 18 | Generalized h - index for disclosing latent facts in citation networks 显示文摘 | SIDIROPOULOS A KATSAROS D MANOLOPOULOS Y | 2007 | Scientometrics2007，72，2： | 1 |
| 19 | Cell adhesion molecules: role and clinical significance in cancer显示文摘 | MAKRILIA N KOLLIAS A MANOLOPOULOS L | 2009 | Cancer Invest2009，27，10： | 1 |
| 20 | Linking Alzheimer\'s disease to insulin resistance: the FoxO response to oxidative stress显示文摘 | Manolopoulos K N Klotz L O Korsten P | 2010 | Mol Psyc Hiatry2010，15，11： | 1 |
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