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| 1 | Is diabetes a causal agent for colorectal cancer? Pathophysiological and molecular mechanisms显示文摘The possible relationship between diabetes mellitus (DM) and colorectal cancer (CRC), concerning pathophysiological and molecular mechanisms is highlighted in this review. The most recent and complete articles and developments in this particular field were thoroughly reviewed. Common risk factors, such as obesity, sedentary lifestyle, and Western diet between DM and CRC, led to the theory that DM might be a causal agent for CRC development. Various studies have connected type 2 DM and CRC, either proximal or distal, in both sexes. Additionally, chronic insulin treatment has been linked with increased colorectal tumor risk among type 2 diabetic patients. Interestingly, elevated hemoglobin A1c has been proven to be an independent predictor of aggressive clinical behavior in CRC patients. These mechanisms include the insulin-like growth factor-hyperinsulinemia theory and the participation of oncogenic intracellular signaling pathways. Furthermore, it has been proposed that Cox-2 inhibitors might have a role in decreasing the incidence of CRC. Finally, the use of statins to reduce the risk for colon cancer in patients with diabetes has remained controversial. Diabetic patients over 50 should receive counseling regarding their elevated risk for CRC, and screening colonoscopy should be recommended before initiating insulin therapy. However, there are no current guidelines, and this strategy is not yet applicable to some countries, as the corresponding risk would not allow screening colonoscopy to be adopted. There is strong evidence to indicate that DM is a causal agent for CRC development. This conclusion provides new impetus for re-evaluating CRC screening worldwide. | Olga Giouleme Michael D Diamantidis Marios G Katsaros | 2011 | World Journal of Gastroenterology2011，17，4： | 15 |
| 2 | Prognostic value of human kallikrein 10 expression in epithelial ovarian carcinoma显示文摘 | Luo LY Katsaros D Scorilas A | 2001 | Clin Cancer Res2001，7，9： | 1 |
| 3 | Prognostic value of human kallikrein 10 expression in epithelial ovarian carcinoma显示文摘 | Luo LY Katsaros D Scorilas A | | 0，，08： | 1 |
| 4 | The serum concen- tration of human kallikrein 10 represents a novel biomark- er for ovarian cancer diagnosis and prognosis 显示文摘 | Luo LY Katsaros D Scorilas A | 2003 | Cancer Res2003，63，4： | 1 |
| 5 | Immunofluorometric quantitation and histochemical localiaation of kallikrein 6 protein in ovarian cancer tissue: a new independent unfavourable prognostic biomarker显示文摘 | Hoffman BR Katsaros D Scorilas A | 2002 | Br J Cancer2002，87，7： | 1 |
| 6 | Aberrant promoter methylation of multiple genes in malignant ovarian tμmol/Lors and in ovarian tμmol/Lors with low malignant potential显示文摘 | Wiley A Katsaros D Chen H | 2006 | Cancer2006，107，2： | 1 |
| 7 | Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer显示文摘 | Zhang L Conejo-Garcia JR Katsaros D | 2003 | N Engl J Med2003，348，： | 1 |
| 8 | Generalized Hirsch h-index for disclosing latent facts in citation networks显示文摘 | Sidiropoulos A Katsaros D Manolopoulos Y | 2007 | Scientometrics2007，72，2： | 1 |
| 9 | The serum concentration of human kallikrein 10 represents a novel biomarker for ovarian cancer diagnosis and prognosis显示文摘 | Luo LY Katsaros D Scorilas A | | 0，，04： | 1 |
| 10 | Architectural requirements for cloud computing systems: an enterprise cloud approach显示文摘 | RIMAL B P JUKAN A KATSAROS D | 2011 | Journal of Grid Computing2011，9，1： | 1 |
| 11 | B7-H4 is over-expressed in early-stage ovarian cancer and is independent of CA125 expression显示文摘 | Simon 1 Katsaros D Rigault de la Longrais I | 2007 | Gynecol Oncol2007，106，2： | 1 |
| 12 | Overexpression of the MET/HGF receptor in ovarian cancer 显示文摘 | DI RENZO M F OLIVERO M KATSAROS D | 1994 | Int J Cancer1994，58，5： | 1 |
| 13 | The serum concentration of human kallikrein 10 represents a novel biomarker for ovarian eancerdiagnosis and prognosis显示文摘 | Luo LY Katsaros D Scorilas A | 2003 | Cancer Res2003，63，4： | 1 |
| 14 | Higher human kallikrein gene 4 (k1k4) expression indicates poor prognosis of ovarian cancer patients显示文摘 | Obiezu C V Scorilas A Katsaros D | 2001 | Clin Cancer Res2001，7，8： | 1 |
| 15 | A data mining approach for location prediction in mobile environments显示文摘 | Yavns G Katsaros D Ulusoy O | | 0，，02： | 1 |
| 16 | Pre- fetching in content distribution networks via web communi- ties identification and outsourcing 显示文摘 | SIDIROPOULOS A PALLIS G KATSAROS D | 2008 | World wide web2008，11，1： | 1 |
| 17 | Methylation of tumor suppressor gene p16 and prognosis of epithelial ovarian cancer显示文摘 | Katsaros D Cho W Singal R | 2004 | Gynecol Oncol2004，94，3： | 1 |
| 18 | Generalized hirsch h-index for disclosing latent facts in citation networks 显示文摘 | SIDIROPOULOS A KATSAROS D MANOLOPOULOS Y | 2007 | Scientometrics2007，72，2： | 1 |
| 19 | B7-H4 is overexpressed in early-stage ovarian cancer and is independent of CAl25 expression显示文摘 | Simon I Katsaros D Rigault de la Longrais I | 2007 | Gynecol Oncol2007，106，2： | 1 |
| 20 | The relationship of insulin - likegrowth factor - II,insulin - like growth factor binding protein - 3,andestrogen receptor - alpha expression to disease progression in epithelialovarian cancer显示文摘 | LuL Katsaros D Wiley A | 2006 | Clin Cancer Res2006，12，4： | 1 |
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